HAS1high cancer associated fibroblasts located at the tumor invasion front zone promote oral squamous cell carcinoma invasion via ECM remodeling

HAS1high cancer associated fibroblasts located at the tumor invasion front zone promote oral squamous cell carcinoma invasion via ECM remodeling

Abstract Background Although tumor cell heterogeneity between the tumor center (TC) and invasion front (IF) of oral squamous cell carcinoma (OSCC) is well documented, the morphological, molecular, and functional characteristics of cancer-associated fibroblasts (CAFs) in these regions remain poorly u...

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Bibliographic Details
Main Authors: Wanyong Jin, Qiuya Yu, Liyuan Yu, Ting Zhou, Xiren Wang, Wanqiu Lu, Xiaoxin Zhang, Liang Ding, Qingang Hu, Yanhong Ni
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Oral squamous cell carcinoma
Cancer associated fibroblast
Invasion front
Extracellular matrix remodeling
Online Access:https://doi.org/10.1186/s13046-025-03493-6
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