Clinical outcome and volumetric 3D analysis of biofluorescence imaging system guided surgery for Medication-Related Osteonecrosis of the Jaw(MRONJ)
Abstract Background This study aims to evaluate the clinical outcome of biofluorescent imaging system (BIS) guided MRONJ surgery through analyzing 3D volumetric changes in CBCT data of bone structure. Methods BIS-guided surgery for MRONJ surgery was performed by grinding red-fluorescent area from re...
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| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-025-05484-7 |
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| author | Sooshin Hwang Hyouk Keun Jee Yesel Kim Hong-Cheol Yoon Pil-Young Yun Jeong-Kui Ku |
| author_facet | Sooshin Hwang Hyouk Keun Jee Yesel Kim Hong-Cheol Yoon Pil-Young Yun Jeong-Kui Ku |
| author_sort | Sooshin Hwang |
| collection | DOAJ |
| description | Abstract Background This study aims to evaluate the clinical outcome of biofluorescent imaging system (BIS) guided MRONJ surgery through analyzing 3D volumetric changes in CBCT data of bone structure. Methods BIS-guided surgery for MRONJ surgery was performed by grinding red-fluorescent area from remained residual bone detected by Qray-pen. CBCT data was collected preoperatively, postoperatively, and at last follow-up more than 3 months of each patient. Healing ratio per month was calculated through measuring difference between postoperative defect and last follow-up defect volume by analyzing CBCT. Results With mean follow-up period of 7.8 ± 4.8 months, twelve MRONJ surgeries of 11 patients (2 males, 9 females, mean 72.8 ± 13.7 years old) showed bone healing tendency without recurrence in average healing ratio of 5.49 ± 2.22% per month, with complete soft tissue closure. It was observed that the healing ratio per month did not show statistically significant differences based on location of MRONJ, size of post-operative defect volume, nor duration of bisphosphonate intake before surgery. Conclusions Based on three-dimensional bone analysis, efficacy of BIS-based MRONJ surgery was proved through the recovery pattern of underlying bone structure and no recurrence sign showing. Clinical trial registration Not applicable. |
| format | Article |
| id | doaj-art-f40ddec4410241199cf91130ea417e3b |
| institution | Kabale University |
| issn | 1472-6831 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Oral Health |
| spelling | doaj-art-f40ddec4410241199cf91130ea417e3b2025-01-26T12:55:09ZengBMCBMC Oral Health1472-68312025-01-012511810.1186/s12903-025-05484-7Clinical outcome and volumetric 3D analysis of biofluorescence imaging system guided surgery for Medication-Related Osteonecrosis of the Jaw(MRONJ)Sooshin Hwang0Hyouk Keun Jee1Yesel Kim2Hong-Cheol Yoon3Pil-Young Yun4Jeong-Kui Ku5Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang HospitalDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Institute of Oral Bioscience, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National UniversityDepartment of Electronic Claims Review Division, Division of Claims Review Standards Department, Health Insurance Review and Assessment ServiceBESTDEN Dental ClinicDepartment of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang HospitalDepartment of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang HospitalAbstract Background This study aims to evaluate the clinical outcome of biofluorescent imaging system (BIS) guided MRONJ surgery through analyzing 3D volumetric changes in CBCT data of bone structure. Methods BIS-guided surgery for MRONJ surgery was performed by grinding red-fluorescent area from remained residual bone detected by Qray-pen. CBCT data was collected preoperatively, postoperatively, and at last follow-up more than 3 months of each patient. Healing ratio per month was calculated through measuring difference between postoperative defect and last follow-up defect volume by analyzing CBCT. Results With mean follow-up period of 7.8 ± 4.8 months, twelve MRONJ surgeries of 11 patients (2 males, 9 females, mean 72.8 ± 13.7 years old) showed bone healing tendency without recurrence in average healing ratio of 5.49 ± 2.22% per month, with complete soft tissue closure. It was observed that the healing ratio per month did not show statistically significant differences based on location of MRONJ, size of post-operative defect volume, nor duration of bisphosphonate intake before surgery. Conclusions Based on three-dimensional bone analysis, efficacy of BIS-based MRONJ surgery was proved through the recovery pattern of underlying bone structure and no recurrence sign showing. Clinical trial registration Not applicable.https://doi.org/10.1186/s12903-025-05484-7Minimally invasive surgeryOsteomyelitisOsteonecrosis of the jawQuantitative light-induced fluorescence |
| spellingShingle | Sooshin Hwang Hyouk Keun Jee Yesel Kim Hong-Cheol Yoon Pil-Young Yun Jeong-Kui Ku Clinical outcome and volumetric 3D analysis of biofluorescence imaging system guided surgery for Medication-Related Osteonecrosis of the Jaw(MRONJ) BMC Oral Health Minimally invasive surgery Osteomyelitis Osteonecrosis of the jaw Quantitative light-induced fluorescence |
| title | Clinical outcome and volumetric 3D analysis of biofluorescence imaging system guided surgery for Medication-Related Osteonecrosis of the Jaw(MRONJ) |
| title_full | Clinical outcome and volumetric 3D analysis of biofluorescence imaging system guided surgery for Medication-Related Osteonecrosis of the Jaw(MRONJ) |
| title_fullStr | Clinical outcome and volumetric 3D analysis of biofluorescence imaging system guided surgery for Medication-Related Osteonecrosis of the Jaw(MRONJ) |
| title_full_unstemmed | Clinical outcome and volumetric 3D analysis of biofluorescence imaging system guided surgery for Medication-Related Osteonecrosis of the Jaw(MRONJ) |
| title_short | Clinical outcome and volumetric 3D analysis of biofluorescence imaging system guided surgery for Medication-Related Osteonecrosis of the Jaw(MRONJ) |
| title_sort | clinical outcome and volumetric 3d analysis of biofluorescence imaging system guided surgery for medication related osteonecrosis of the jaw mronj |
| topic | Minimally invasive surgery Osteomyelitis Osteonecrosis of the jaw Quantitative light-induced fluorescence |
| url | https://doi.org/10.1186/s12903-025-05484-7 |
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