Bacterial Hachiman complex executes DNA cleavage for antiphage defense

Bacterial Hachiman complex executes DNA cleavage for antiphage defense

Abstract Bacteria have developed a variety of immune systems to combat phage infections. The Hachiman system is a novel prokaryotic antiphage defense system comprising HamA and HamB proteins, which contains the DUF1837 and helicase domains, respectively. However, the defense mechanism remains only p...

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Main Authors: Yongqing Cui, Zhikang Dai, Yufei Ouyang, Chunyang Fu, Yanjing Wang, Xueting Chen, Kaiyue Yang, Shuyue Zheng, Wenwen Wang, Pan Tao, Zeyuan Guan, Tingting Zou
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57851-1
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