Association of Sleep Duration With Incident Carotid Plaque: A Prospective Cohort Study
Background Sleep is an important determinant of cardiovascular health. We sought to investigate the longitudinal association between sleep duration and incident carotid plaque in a rural Chinese population. Methods This population‐based prospective cohort study included 1004 rural residents (age ≥40...
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Wiley
2025-05-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.124.039215 |
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| author | Meijie Chen Xiaotong Ma Yuan Xue Xiang Wang Yuanyuan Zhao Peng Yan Xiaohui Liu Yifeng Du Chengxuan Qiu Qinjian Sun |
| author_facet | Meijie Chen Xiaotong Ma Yuan Xue Xiang Wang Yuanyuan Zhao Peng Yan Xiaohui Liu Yifeng Du Chengxuan Qiu Qinjian Sun |
| author_sort | Meijie Chen |
| collection | DOAJ |
| description | Background Sleep is an important determinant of cardiovascular health. We sought to investigate the longitudinal association between sleep duration and incident carotid plaque in a rural Chinese population. Methods This population‐based prospective cohort study included 1004 rural residents (age ≥40 years) who were free of carotid plaque and had no history of clinical stroke and transient ischemic attack at baseline (2017). Incident carotid plaques were detected by carotid ultrasound images at follow‐up (2021). Multivariable Cox regression was used to associate sleep duration with the presence and severity of incident carotid plaques. Restricted cubic splines analyses were conducted to assess dose–response association between sleep duration and incident carotid plaques. Results During the mean follow‐up of 3.95 (SD=0.14) years, 214 (21.3%) of the 1004 participants were found to have incident carotid plaques. A short sleep duration (<7 versus 7–9 hours) was associated with multivariable‐adjusted hazard ratio (95% CI) of 1.58 (1.10–2.28) for carotid plaques, 2.96 (1.38–6.36) for greater carotid plaque thickness, and 2.57 (1.33–4.97) for multiple carotid plaques; those associations remained significant in participants with low‐to‐intermediate traditional cardiovascular disease risk. Long sleep duration (>9 versus 7–9 hours) was not significantly associated with carotid plaques. Restricted cubic splines supported the association of short, but not long, sleep duration with increased risk of incident carotid plaques. Conclusions A short sleep duration is a risk factor for carotid plaques, even among individuals with low‐to‐intermediate cardiovascular disease risk. This suggests that short sleep duration may be a potential target for early interventions to delay carotid atherosclerosis. Registration URL: https://www.chictr.org.cn; Unique Identifier: ChiCTR1800017197. |
| format | Article |
| id | doaj-art-f408d09fa9de46a682d0dfd2044c39b8 |
| institution | OA Journals |
| issn | 2047-9980 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-f408d09fa9de46a682d0dfd2044c39b82025-08-20T01:52:19ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802025-05-0114910.1161/JAHA.124.039215Association of Sleep Duration With Incident Carotid Plaque: A Prospective Cohort StudyMeijie Chen0Xiaotong Ma1Yuan Xue2Xiang Wang3Yuanyuan Zhao4Peng Yan5Xiaohui Liu6Yifeng Du7Chengxuan Qiu8Qinjian Sun9Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong P. R. ChinaKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong P. R. ChinaKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong P. R. ChinaKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong P. R. ChinaKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong P. R. ChinaKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong P. R. ChinaKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong P. R. ChinaKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong P. R. ChinaAging Research Center, Department of Neurobiology Care Sciences and Society, Karolinska Institutet‐Stockholm University Stockholm SwedenKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong P. R. ChinaBackground Sleep is an important determinant of cardiovascular health. We sought to investigate the longitudinal association between sleep duration and incident carotid plaque in a rural Chinese population. Methods This population‐based prospective cohort study included 1004 rural residents (age ≥40 years) who were free of carotid plaque and had no history of clinical stroke and transient ischemic attack at baseline (2017). Incident carotid plaques were detected by carotid ultrasound images at follow‐up (2021). Multivariable Cox regression was used to associate sleep duration with the presence and severity of incident carotid plaques. Restricted cubic splines analyses were conducted to assess dose–response association between sleep duration and incident carotid plaques. Results During the mean follow‐up of 3.95 (SD=0.14) years, 214 (21.3%) of the 1004 participants were found to have incident carotid plaques. A short sleep duration (<7 versus 7–9 hours) was associated with multivariable‐adjusted hazard ratio (95% CI) of 1.58 (1.10–2.28) for carotid plaques, 2.96 (1.38–6.36) for greater carotid plaque thickness, and 2.57 (1.33–4.97) for multiple carotid plaques; those associations remained significant in participants with low‐to‐intermediate traditional cardiovascular disease risk. Long sleep duration (>9 versus 7–9 hours) was not significantly associated with carotid plaques. Restricted cubic splines supported the association of short, but not long, sleep duration with increased risk of incident carotid plaques. Conclusions A short sleep duration is a risk factor for carotid plaques, even among individuals with low‐to‐intermediate cardiovascular disease risk. This suggests that short sleep duration may be a potential target for early interventions to delay carotid atherosclerosis. Registration URL: https://www.chictr.org.cn; Unique Identifier: ChiCTR1800017197.https://www.ahajournals.org/doi/10.1161/JAHA.124.039215carotid arteriescarotid plaquecohort studyincident atherosclerotic plaquesleep duration |
| spellingShingle | Meijie Chen Xiaotong Ma Yuan Xue Xiang Wang Yuanyuan Zhao Peng Yan Xiaohui Liu Yifeng Du Chengxuan Qiu Qinjian Sun Association of Sleep Duration With Incident Carotid Plaque: A Prospective Cohort Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease carotid arteries carotid plaque cohort study incident atherosclerotic plaque sleep duration |
| title | Association of Sleep Duration With Incident Carotid Plaque: A Prospective Cohort Study |
| title_full | Association of Sleep Duration With Incident Carotid Plaque: A Prospective Cohort Study |
| title_fullStr | Association of Sleep Duration With Incident Carotid Plaque: A Prospective Cohort Study |
| title_full_unstemmed | Association of Sleep Duration With Incident Carotid Plaque: A Prospective Cohort Study |
| title_short | Association of Sleep Duration With Incident Carotid Plaque: A Prospective Cohort Study |
| title_sort | association of sleep duration with incident carotid plaque a prospective cohort study |
| topic | carotid arteries carotid plaque cohort study incident atherosclerotic plaque sleep duration |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.124.039215 |
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