Secretory breast carcinoma in adulthood: A case report with literature review
Introduction. Secretory breast carcinoma is rare subtype of breast carcinoma which occurs primarily in children and young adults, so in the past it was called juvenile carcinoma. Case report. A 67-year-old female patient presented with mass of the right breast since one month. After physical, routin...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2020-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2020/0042-84501900143I.pdf |
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| author | Ivković-Kapicl Tatjana Vicko Ferenc Popović Lazar Đilas Dragana Lakić Tanja |
| author_facet | Ivković-Kapicl Tatjana Vicko Ferenc Popović Lazar Đilas Dragana Lakić Tanja |
| author_sort | Ivković-Kapicl Tatjana |
| collection | DOAJ |
| description | Introduction. Secretory breast carcinoma is rare subtype of breast carcinoma which occurs primarily in children and young adults, so in the past it was called juvenile carcinoma. Case report. A 67-year-old female patient presented with mass of the right breast since one month. After physical, routine laboratory examination and mammography, core needle biopsy was performed and histopathological examination confirmed invasive carcinoma. Immunohistochemically, estrogen-receptors (ER) and progesteron-receptors (PR) showed weak positive reaction in 10% of tumor cells, while human epidermal growth factor receptor-2 (HER-2) was without expression. After an adequate preoperative preparation, operation was done – quadrantectomy with sentinel lymph node biopsy. Postoperatively, the patient was treated with 6 cycles of cyclophosphamide, methotrexate and fluorouracil (CMF) combination, radiotherapy (60 Gy) and tamoxifen. After 5-year follow-up the patient had no signs of the disease. Conclusion. Secretory breast cancer is a rare subtype of invasive breast carcinoma with wide age range of occurrence and good prognosis despite its triplenegative immunophenotype. Although the therapeutic management is non-consensual for this breast cancer special type, surgery is considered the mainstay of the treatment as well as the adjuvant chemotherapy and radiation. |
| format | Article |
| id | doaj-art-f408989b7ec847b98b07ba16db73fd71 |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-f408989b7ec847b98b07ba16db73fd712025-08-20T02:04:55ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202020-01-0177555655910.2298/VSP180126143I0042-84501900143ISecretory breast carcinoma in adulthood: A case report with literature reviewIvković-Kapicl Tatjana0Vicko Ferenc1Popović Lazar2Đilas Dragana3Lakić Tanja4The Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaThe Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaThe Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaThe Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Clinical Center of Vojvodina, Novi Sad, SerbiaIntroduction. Secretory breast carcinoma is rare subtype of breast carcinoma which occurs primarily in children and young adults, so in the past it was called juvenile carcinoma. Case report. A 67-year-old female patient presented with mass of the right breast since one month. After physical, routine laboratory examination and mammography, core needle biopsy was performed and histopathological examination confirmed invasive carcinoma. Immunohistochemically, estrogen-receptors (ER) and progesteron-receptors (PR) showed weak positive reaction in 10% of tumor cells, while human epidermal growth factor receptor-2 (HER-2) was without expression. After an adequate preoperative preparation, operation was done – quadrantectomy with sentinel lymph node biopsy. Postoperatively, the patient was treated with 6 cycles of cyclophosphamide, methotrexate and fluorouracil (CMF) combination, radiotherapy (60 Gy) and tamoxifen. After 5-year follow-up the patient had no signs of the disease. Conclusion. Secretory breast cancer is a rare subtype of invasive breast carcinoma with wide age range of occurrence and good prognosis despite its triplenegative immunophenotype. Although the therapeutic management is non-consensual for this breast cancer special type, surgery is considered the mainstay of the treatment as well as the adjuvant chemotherapy and radiation.http://www.doiserbia.nb.rs/img/doi/0042-8450/2020/0042-84501900143I.pdfbreast neoplasmssecretory breast carcinomatriple negative breast neoplasmsdiagnosismastectomy, segmentaladult |
| spellingShingle | Ivković-Kapicl Tatjana Vicko Ferenc Popović Lazar Đilas Dragana Lakić Tanja Secretory breast carcinoma in adulthood: A case report with literature review Vojnosanitetski Pregled breast neoplasms secretory breast carcinoma triple negative breast neoplasms diagnosis mastectomy, segmental adult |
| title | Secretory breast carcinoma in adulthood: A case report with literature review |
| title_full | Secretory breast carcinoma in adulthood: A case report with literature review |
| title_fullStr | Secretory breast carcinoma in adulthood: A case report with literature review |
| title_full_unstemmed | Secretory breast carcinoma in adulthood: A case report with literature review |
| title_short | Secretory breast carcinoma in adulthood: A case report with literature review |
| title_sort | secretory breast carcinoma in adulthood a case report with literature review |
| topic | breast neoplasms secretory breast carcinoma triple negative breast neoplasms diagnosis mastectomy, segmental adult |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2020/0042-84501900143I.pdf |
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