Serum adiponectin level is negatively related to insulin resistance in women with polycystic ovary syndrome
Purpose: Our study aimed to assess the relationship between serum adipokines and insulin resistance (IR) in women with polycystic ovary syndrome (PCOS) and explore the predictive value of adipokines on IR in PCOS. Methods: This was a prospective cross-sectional study. 154 women with PCOS were includ...
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Bioscientifica
2024-12-01
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| Series: | Endocrine Connections |
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| author | Jie Yang Min Lin Xiaoyan Tian Chujun Li Haocun Wu Ling Deng Xuelan Li Xin Chen |
| author_facet | Jie Yang Min Lin Xiaoyan Tian Chujun Li Haocun Wu Ling Deng Xuelan Li Xin Chen |
| author_sort | Jie Yang |
| collection | DOAJ |
| description | Purpose: Our study aimed to assess the relationship between serum adipokines and insulin resistance (IR) in women with polycystic ovary syndrome (PCOS) and explore the predictive value of adipokines on IR in PCOS. Methods: This was a prospective cross-sectional study. 154 women with PCOS were included from July 2021 to September 2022 who underwent gonadal steroid hormone measurement, lipid profile, oral glucose tolerance test and homoeostasis model assessment (HOMA)-IR. Adiponectin (APN), leptin and secreted frizzled-related protein (Sfrp5) were measured by immunoturbidimetry and enzyme-linked immunosorbent assay. Women with PCOS were categorised based on the presence of IR. Results: Women with PCOS with IR (n = 99) had significantly lower APN level and APN-to-leptin ratio (A/L ratio) than those without IR (n = 55), whereas serum levels of leptin and Sfrp5 were similar between the two groups. In multivariable linear regression analysis, serum log (APN) and log (A/L ratio) were associated with log (HOMA-IR), and the association was statistically significant after adjusting for body mass index and free androgen index. The area under the receiver operating characteristic curve (95% CI) for APN and A/L ratio was 0.726 (0.644–0.807; P < 0.001) and 0.660 (0.569–0.751; P < 0.01), respectively, with cutoff values of 5.225 mg/L (Youden index ¼ 0.364) and 1.438 mg/L (Youden index ¼ 0.265). Conclusion: Our study demonstrated that serum APN was negatively related to IR. Serum APN may be useful as a clinical marker for IR in women with PCOS. Our findings warrant further investigations into the function of APN in the pathogenesis of IR in women with PCOS. |
| format | Article |
| id | doaj-art-f402cd87a3fe454ea2acec79bbe3381f |
| institution | DOAJ |
| issn | 2049-3614 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Bioscientifica |
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| series | Endocrine Connections |
| spelling | doaj-art-f402cd87a3fe454ea2acec79bbe3381f2025-08-20T02:40:35ZengBioscientificaEndocrine Connections2049-36142024-12-0114110.1530/EC-24-04011Serum adiponectin level is negatively related to insulin resistance in women with polycystic ovary syndromeJie Yang0Min Lin1Xiaoyan Tian2Chujun Li3Haocun Wu4Ling Deng5Xuelan Li6Xin Chen7Reproductive Medicine Center, Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, ChinaReproductive Medicine Center, The First People’s Hospital of Yulin, Yulin, Guangxi Zhuang Autonomous Region, ChinaReproductive Medicine Center, Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, ChinaReproductive Medicine Center, Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, ChinaDepartment of Clinical Laboratory, Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, ChinaReproductive Medicine Center, Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, ChinaReproductive Medicine Center, Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, ChinaReproductive Medicine Center, Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, ChinaPurpose: Our study aimed to assess the relationship between serum adipokines and insulin resistance (IR) in women with polycystic ovary syndrome (PCOS) and explore the predictive value of adipokines on IR in PCOS. Methods: This was a prospective cross-sectional study. 154 women with PCOS were included from July 2021 to September 2022 who underwent gonadal steroid hormone measurement, lipid profile, oral glucose tolerance test and homoeostasis model assessment (HOMA)-IR. Adiponectin (APN), leptin and secreted frizzled-related protein (Sfrp5) were measured by immunoturbidimetry and enzyme-linked immunosorbent assay. Women with PCOS were categorised based on the presence of IR. Results: Women with PCOS with IR (n = 99) had significantly lower APN level and APN-to-leptin ratio (A/L ratio) than those without IR (n = 55), whereas serum levels of leptin and Sfrp5 were similar between the two groups. In multivariable linear regression analysis, serum log (APN) and log (A/L ratio) were associated with log (HOMA-IR), and the association was statistically significant after adjusting for body mass index and free androgen index. The area under the receiver operating characteristic curve (95% CI) for APN and A/L ratio was 0.726 (0.644–0.807; P < 0.001) and 0.660 (0.569–0.751; P < 0.01), respectively, with cutoff values of 5.225 mg/L (Youden index ¼ 0.364) and 1.438 mg/L (Youden index ¼ 0.265). Conclusion: Our study demonstrated that serum APN was negatively related to IR. Serum APN may be useful as a clinical marker for IR in women with PCOS. Our findings warrant further investigations into the function of APN in the pathogenesis of IR in women with PCOS.https://ec.bioscientifica.com/view/journals/ec/14/1/EC-24-0401.xmlpolycystic ovary syndromeinsulin resistanceadipokinesadiponectin to leptin ratiometabolic diseases |
| spellingShingle | Jie Yang Min Lin Xiaoyan Tian Chujun Li Haocun Wu Ling Deng Xuelan Li Xin Chen Serum adiponectin level is negatively related to insulin resistance in women with polycystic ovary syndrome Endocrine Connections polycystic ovary syndrome insulin resistance adipokines adiponectin to leptin ratio metabolic diseases |
| title | Serum adiponectin level is negatively related to insulin resistance in women with polycystic ovary syndrome |
| title_full | Serum adiponectin level is negatively related to insulin resistance in women with polycystic ovary syndrome |
| title_fullStr | Serum adiponectin level is negatively related to insulin resistance in women with polycystic ovary syndrome |
| title_full_unstemmed | Serum adiponectin level is negatively related to insulin resistance in women with polycystic ovary syndrome |
| title_short | Serum adiponectin level is negatively related to insulin resistance in women with polycystic ovary syndrome |
| title_sort | serum adiponectin level is negatively related to insulin resistance in women with polycystic ovary syndrome |
| topic | polycystic ovary syndrome insulin resistance adipokines adiponectin to leptin ratio metabolic diseases |
| url | https://ec.bioscientifica.com/view/journals/ec/14/1/EC-24-0401.xml |
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