Bioresorbable fibers for interstitial null-separation diffuse optical spectroscopy using fast temporal gating
Bioresorbable fibers are an exciting prospect as probes and implants to provide optical access to the human body. In this work, we demonstrate interstitial spectroscopy with bioresorbable fibers at null distance, using time-domain diffuse optics that disentangles absorption from scattering propertie...
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| Format: | Article |
| Language: | English |
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IOP Publishing
2025-01-01
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| Series: | JPhys Photonics |
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| Online Access: | https://doi.org/10.1088/2515-7647/ada656 |
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| author | Vamshi Damagatla Nadia G Boetti Laura Di Sieno Diego Pugliese Ilaria Bargigia Davide Janner Alberto Dalla Mora Antonio Pifferi |
| author_facet | Vamshi Damagatla Nadia G Boetti Laura Di Sieno Diego Pugliese Ilaria Bargigia Davide Janner Alberto Dalla Mora Antonio Pifferi |
| author_sort | Vamshi Damagatla |
| collection | DOAJ |
| description | Bioresorbable fibers are an exciting prospect as probes and implants to provide optical access to the human body. In this work, we demonstrate interstitial spectroscopy with bioresorbable fibers at null distance, using time-domain diffuse optics that disentangles absorption from scattering properties and probes the tissues up to a depth of a few cm around the fiber tips. We exploit a fast-gated single-photon avalanche diode with $\gt$ 55 dB of dynamic range to overcome the burst of ‘early’ photons hiding the information of absorption from deep tissues. We tested the absorption linearity—retrieving the water spectrum in the 700–950 nm range with $\gt$ 85% accuracy over two decades of absorption change—and verified the hypothesis of a scattering-independent absorption retrieval. Further, we were able to detect spectral changes at a distance of 1 cm from an inclusion embedded in a biological tissue. Time-domain diffuse optical spectroscopy with bioresorbable fibers could detect spectral changes without being affected by blood extravasation at the fiber tips and could help for long-term monitoring in tissue healing, thermal treatment, photodynamic therapy and ultimately, towards minimally invasive medical procedures. |
| format | Article |
| id | doaj-art-f3fc415bdef0409ebfd972a660a4ae88 |
| institution | Kabale University |
| issn | 2515-7647 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | JPhys Photonics |
| spelling | doaj-art-f3fc415bdef0409ebfd972a660a4ae882025-01-20T11:43:21ZengIOP PublishingJPhys Photonics2515-76472025-01-017101501110.1088/2515-7647/ada656Bioresorbable fibers for interstitial null-separation diffuse optical spectroscopy using fast temporal gatingVamshi Damagatla0https://orcid.org/0000-0003-4140-387XNadia G Boetti1https://orcid.org/0000-0002-5269-2390Laura Di Sieno2https://orcid.org/0000-0002-3028-3705Diego Pugliese3https://orcid.org/0000-0002-6431-1655Ilaria Bargigia4https://orcid.org/0000-0003-4428-7958Davide Janner5https://orcid.org/0000-0001-7954-979XAlberto Dalla Mora6https://orcid.org/0000-0002-2783-6217Antonio Pifferi7https://orcid.org/0000-0002-2261-2089Politecnico di Milano , Dipartimento di Fisica, Milano, ItalyFondazione LINKS—Leading Innovation and Knowledge for Society , Torino, ItalyPolitecnico di Milano , Dipartimento di Fisica, Milano, ItalyIstituto Nazionale di Ricerca Metrologica (INRiM ), Torino, Italy; Politecnico di Torino , Dipartimento di Scienza Applicata e Tecnologia and INSTM research unit, Torino, ItalyPolitecnico di Milano , Dipartimento di Fisica, Milano, Italy; Center for Nano Science and Technology@PoliMi, Istituto Italiano di Tecnologia , Milano, ItalyPolitecnico di Torino , Dipartimento di Scienza Applicata e Tecnologia and INSTM research unit, Torino, ItalyPolitecnico di Milano , Dipartimento di Fisica, Milano, ItalyPolitecnico di Milano , Dipartimento di Fisica, Milano, Italy; Istituto di Fotonica e Nanotecnologie , Consiglio Nazionale delle Ricerche, Milano, ItalyBioresorbable fibers are an exciting prospect as probes and implants to provide optical access to the human body. In this work, we demonstrate interstitial spectroscopy with bioresorbable fibers at null distance, using time-domain diffuse optics that disentangles absorption from scattering properties and probes the tissues up to a depth of a few cm around the fiber tips. We exploit a fast-gated single-photon avalanche diode with $\gt$ 55 dB of dynamic range to overcome the burst of ‘early’ photons hiding the information of absorption from deep tissues. We tested the absorption linearity—retrieving the water spectrum in the 700–950 nm range with $\gt$ 85% accuracy over two decades of absorption change—and verified the hypothesis of a scattering-independent absorption retrieval. Further, we were able to detect spectral changes at a distance of 1 cm from an inclusion embedded in a biological tissue. Time-domain diffuse optical spectroscopy with bioresorbable fibers could detect spectral changes without being affected by blood extravasation at the fiber tips and could help for long-term monitoring in tissue healing, thermal treatment, photodynamic therapy and ultimately, towards minimally invasive medical procedures.https://doi.org/10.1088/2515-7647/ada656diffuse opticstime-of-flightinterstitial fiber spectroscopytime-gatingbioresorbable fibers |
| spellingShingle | Vamshi Damagatla Nadia G Boetti Laura Di Sieno Diego Pugliese Ilaria Bargigia Davide Janner Alberto Dalla Mora Antonio Pifferi Bioresorbable fibers for interstitial null-separation diffuse optical spectroscopy using fast temporal gating JPhys Photonics diffuse optics time-of-flight interstitial fiber spectroscopy time-gating bioresorbable fibers |
| title | Bioresorbable fibers for interstitial null-separation diffuse optical spectroscopy using fast temporal gating |
| title_full | Bioresorbable fibers for interstitial null-separation diffuse optical spectroscopy using fast temporal gating |
| title_fullStr | Bioresorbable fibers for interstitial null-separation diffuse optical spectroscopy using fast temporal gating |
| title_full_unstemmed | Bioresorbable fibers for interstitial null-separation diffuse optical spectroscopy using fast temporal gating |
| title_short | Bioresorbable fibers for interstitial null-separation diffuse optical spectroscopy using fast temporal gating |
| title_sort | bioresorbable fibers for interstitial null separation diffuse optical spectroscopy using fast temporal gating |
| topic | diffuse optics time-of-flight interstitial fiber spectroscopy time-gating bioresorbable fibers |
| url | https://doi.org/10.1088/2515-7647/ada656 |
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