Severe Type B Lactic Acidosis in a Rare and Aggressive HIV-Related Lymphoma
We describe the prognostic implication and aggressive clinical course of lymphoma-related lactic acidosis in a rare HIV-related lymphoma. Patient was diagnosed with plasmablastic lymphoma and developed severe lactic acidosis, and was treated on the medical floor and in the medical intensive care uni...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2019/4642925 |
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| _version_ | 1850165323734450176 |
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| author | John Harwood Scott Ashish P. S. Bains Timothy D. Lindsay Xiaofeng Zhao Michael E. Bromberg |
| author_facet | John Harwood Scott Ashish P. S. Bains Timothy D. Lindsay Xiaofeng Zhao Michael E. Bromberg |
| author_sort | John Harwood Scott |
| collection | DOAJ |
| description | We describe the prognostic implication and aggressive clinical course of lymphoma-related lactic acidosis in a rare HIV-related lymphoma. Patient was diagnosed with plasmablastic lymphoma and developed severe lactic acidosis, and was treated on the medical floor and in the medical intensive care unit. Her lactic acidosis was considered to be type B, secondary to her underlying lymphoma since she never had an infectious source, hypovolemic state, or low/high cardiac-output state. The mechanism of the lymphoma-related lactic acidosis is from altered cellular metabolism, thought to aid in lymphoma proliferation, rather than tissue hypoperfusion. It is a rare complication of aggressive lymphomas and signifies a poor prognosis. Patients having this complication should be considered for close monitoring and management in an intensive care unit until definitive treatment (i.e., chemotherapy) can be implemented. |
| format | Article |
| id | doaj-art-f3f5f555b36f4145bf224528f6c2f8ea |
| institution | OA Journals |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-f3f5f555b36f4145bf224528f6c2f8ea2025-08-20T02:21:46ZengWileyCase Reports in Critical Care2090-64202090-64392019-01-01201910.1155/2019/46429254642925Severe Type B Lactic Acidosis in a Rare and Aggressive HIV-Related LymphomaJohn Harwood Scott0Ashish P. S. Bains1Timothy D. Lindsay2Xiaofeng Zhao3Michael E. Bromberg4Department of Medicine, Section of Internal Medicine, Lewis Katz School of Medicine at Temple University Hospital, Philadelphia, PA 19140, USADepartment of Pathology and Laboratory Medicine, Lewis Katz School of Medicine at Temple University Hospital, Philadelphia, PA 19140, USADepartment of Medicine, Section of Internal Medicine, Lewis Katz School of Medicine at Temple University Hospital, Philadelphia, PA 19140, USADepartment of Pathology and Laboratory Medicine, Lewis Katz School of Medicine at Temple University Hospital, Philadelphia, PA 19140, USADepartment of Medicine, Section of Hematology, Lewis Katz School of Medicine at Temple University Hospital, Philadelphia, PA 19140, USAWe describe the prognostic implication and aggressive clinical course of lymphoma-related lactic acidosis in a rare HIV-related lymphoma. Patient was diagnosed with plasmablastic lymphoma and developed severe lactic acidosis, and was treated on the medical floor and in the medical intensive care unit. Her lactic acidosis was considered to be type B, secondary to her underlying lymphoma since she never had an infectious source, hypovolemic state, or low/high cardiac-output state. The mechanism of the lymphoma-related lactic acidosis is from altered cellular metabolism, thought to aid in lymphoma proliferation, rather than tissue hypoperfusion. It is a rare complication of aggressive lymphomas and signifies a poor prognosis. Patients having this complication should be considered for close monitoring and management in an intensive care unit until definitive treatment (i.e., chemotherapy) can be implemented.http://dx.doi.org/10.1155/2019/4642925 |
| spellingShingle | John Harwood Scott Ashish P. S. Bains Timothy D. Lindsay Xiaofeng Zhao Michael E. Bromberg Severe Type B Lactic Acidosis in a Rare and Aggressive HIV-Related Lymphoma Case Reports in Critical Care |
| title | Severe Type B Lactic Acidosis in a Rare and Aggressive HIV-Related Lymphoma |
| title_full | Severe Type B Lactic Acidosis in a Rare and Aggressive HIV-Related Lymphoma |
| title_fullStr | Severe Type B Lactic Acidosis in a Rare and Aggressive HIV-Related Lymphoma |
| title_full_unstemmed | Severe Type B Lactic Acidosis in a Rare and Aggressive HIV-Related Lymphoma |
| title_short | Severe Type B Lactic Acidosis in a Rare and Aggressive HIV-Related Lymphoma |
| title_sort | severe type b lactic acidosis in a rare and aggressive hiv related lymphoma |
| url | http://dx.doi.org/10.1155/2019/4642925 |
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