Statin Utilization for Primary Prevention of Cardiovascular Disease in Patients Developing First ST‐Segment Elevation Myocardial Infarction: A Malaysian Retrospective Cohort Study
ABSTRACT Background and Aims This retrospective cohort study aimed to determine the utilization rate of statin therapy for primary prevention of cardiovascular disease (CVD) and factors associated with its use in patients prior to experiencing their first ST‐elevation myocardial infarction (STEMI)....
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-03-01
|
| Series: | Health Science Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/hsr2.70206 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850207480172249088 |
|---|---|
| author | Abdullah Faiz Zaihan Shairyzah Ahmad Hisham Aina Yazrin Ali Nasiruddin Chia Siang Kow Syed Shahzad Hasan Dinesh Sangarran Ramachandram |
| author_facet | Abdullah Faiz Zaihan Shairyzah Ahmad Hisham Aina Yazrin Ali Nasiruddin Chia Siang Kow Syed Shahzad Hasan Dinesh Sangarran Ramachandram |
| author_sort | Abdullah Faiz Zaihan |
| collection | DOAJ |
| description | ABSTRACT Background and Aims This retrospective cohort study aimed to determine the utilization rate of statin therapy for primary prevention of cardiovascular disease (CVD) and factors associated with its use in patients prior to experiencing their first ST‐elevation myocardial infarction (STEMI). Methods The study included 177 patients admitted for their first episode of STEMI at a Malaysian secondary hospital in 2020. Data were retrospectively collected from the electronic health information system. Logistic regression analysis was performed to identify significant predictors of statin therapy utilization for primary prevention. Results Of the 177 patients, only 15.8% (n = 28) had been prescribed statin therapy for the primary prevention of CVD prior to their first STEMI. Hypertension and dyslipidemia were identified as significant predictors of statin use, with adjusted odds ratios (AOR) of 9.570 (95% CI: 1.859–49.281) and 37.900 (95% CI: 6.716–213.87), respectively. Follow‐up data indicated significantly reduced cholesterol levels post‐STEMI, demonstrating the lipid‐lowering effectiveness of statin therapy. Conclusion This study highlights the low utilization rate of statin therapy for primary prevention of CVD among patients prior to their first STEMI. Despite the proven effectiveness of statins in lowering cholesterol levels post‐STEMI, there is a need to enhance awareness, adherence to guidelines, and efforts to achieve LDL‐C targets through appropriate statin therapy. |
| format | Article |
| id | doaj-art-f3ed93ccb251447780b95740159cd9cf |
| institution | OA Journals |
| issn | 2398-8835 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj-art-f3ed93ccb251447780b95740159cd9cf2025-08-20T02:10:31ZengWileyHealth Science Reports2398-88352025-03-0183n/an/a10.1002/hsr2.70206Statin Utilization for Primary Prevention of Cardiovascular Disease in Patients Developing First ST‐Segment Elevation Myocardial Infarction: A Malaysian Retrospective Cohort StudyAbdullah Faiz Zaihan0Shairyzah Ahmad Hisham1Aina Yazrin Ali Nasiruddin2Chia Siang Kow3Syed Shahzad Hasan4Dinesh Sangarran Ramachandram5Department of Pharmacy Shah Alam Hospital Shah Alam Selangor MalaysiaSchool of Pharmacy University of Nottingham Malaysia Semenyih Selangor MalaysiaSchool of Pharmacy University of Nottingham Malaysia Semenyih Selangor MalaysiaSchool of Pharmacy IMU University Kuala Lumpur Federal Territory of Kuala Lumpur MalaysiaSchool of Applied Sciences University of Huddersfield Queensgate Huddersfield UKSchool of Pharmacy Monash University Malaysia Subang Jaya Selangor MalaysiaABSTRACT Background and Aims This retrospective cohort study aimed to determine the utilization rate of statin therapy for primary prevention of cardiovascular disease (CVD) and factors associated with its use in patients prior to experiencing their first ST‐elevation myocardial infarction (STEMI). Methods The study included 177 patients admitted for their first episode of STEMI at a Malaysian secondary hospital in 2020. Data were retrospectively collected from the electronic health information system. Logistic regression analysis was performed to identify significant predictors of statin therapy utilization for primary prevention. Results Of the 177 patients, only 15.8% (n = 28) had been prescribed statin therapy for the primary prevention of CVD prior to their first STEMI. Hypertension and dyslipidemia were identified as significant predictors of statin use, with adjusted odds ratios (AOR) of 9.570 (95% CI: 1.859–49.281) and 37.900 (95% CI: 6.716–213.87), respectively. Follow‐up data indicated significantly reduced cholesterol levels post‐STEMI, demonstrating the lipid‐lowering effectiveness of statin therapy. Conclusion This study highlights the low utilization rate of statin therapy for primary prevention of CVD among patients prior to their first STEMI. Despite the proven effectiveness of statins in lowering cholesterol levels post‐STEMI, there is a need to enhance awareness, adherence to guidelines, and efforts to achieve LDL‐C targets through appropriate statin therapy.https://doi.org/10.1002/hsr2.70206acute coronary syndromediabetesHMG‐CoA reductase inhibitorlipid loweringprophylaxis |
| spellingShingle | Abdullah Faiz Zaihan Shairyzah Ahmad Hisham Aina Yazrin Ali Nasiruddin Chia Siang Kow Syed Shahzad Hasan Dinesh Sangarran Ramachandram Statin Utilization for Primary Prevention of Cardiovascular Disease in Patients Developing First ST‐Segment Elevation Myocardial Infarction: A Malaysian Retrospective Cohort Study Health Science Reports acute coronary syndrome diabetes HMG‐CoA reductase inhibitor lipid lowering prophylaxis |
| title | Statin Utilization for Primary Prevention of Cardiovascular Disease in Patients Developing First ST‐Segment Elevation Myocardial Infarction: A Malaysian Retrospective Cohort Study |
| title_full | Statin Utilization for Primary Prevention of Cardiovascular Disease in Patients Developing First ST‐Segment Elevation Myocardial Infarction: A Malaysian Retrospective Cohort Study |
| title_fullStr | Statin Utilization for Primary Prevention of Cardiovascular Disease in Patients Developing First ST‐Segment Elevation Myocardial Infarction: A Malaysian Retrospective Cohort Study |
| title_full_unstemmed | Statin Utilization for Primary Prevention of Cardiovascular Disease in Patients Developing First ST‐Segment Elevation Myocardial Infarction: A Malaysian Retrospective Cohort Study |
| title_short | Statin Utilization for Primary Prevention of Cardiovascular Disease in Patients Developing First ST‐Segment Elevation Myocardial Infarction: A Malaysian Retrospective Cohort Study |
| title_sort | statin utilization for primary prevention of cardiovascular disease in patients developing first st segment elevation myocardial infarction a malaysian retrospective cohort study |
| topic | acute coronary syndrome diabetes HMG‐CoA reductase inhibitor lipid lowering prophylaxis |
| url | https://doi.org/10.1002/hsr2.70206 |
| work_keys_str_mv | AT abdullahfaizzaihan statinutilizationforprimarypreventionofcardiovasculardiseaseinpatientsdevelopingfirststsegmentelevationmyocardialinfarctionamalaysianretrospectivecohortstudy AT shairyzahahmadhisham statinutilizationforprimarypreventionofcardiovasculardiseaseinpatientsdevelopingfirststsegmentelevationmyocardialinfarctionamalaysianretrospectivecohortstudy AT ainayazrinalinasiruddin statinutilizationforprimarypreventionofcardiovasculardiseaseinpatientsdevelopingfirststsegmentelevationmyocardialinfarctionamalaysianretrospectivecohortstudy AT chiasiangkow statinutilizationforprimarypreventionofcardiovasculardiseaseinpatientsdevelopingfirststsegmentelevationmyocardialinfarctionamalaysianretrospectivecohortstudy AT syedshahzadhasan statinutilizationforprimarypreventionofcardiovasculardiseaseinpatientsdevelopingfirststsegmentelevationmyocardialinfarctionamalaysianretrospectivecohortstudy AT dineshsangarranramachandram statinutilizationforprimarypreventionofcardiovasculardiseaseinpatientsdevelopingfirststsegmentelevationmyocardialinfarctionamalaysianretrospectivecohortstudy |