Co-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus HKU1 (HCoV-HKU1)
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus HKU1 (HCoV-HKU1) are two forms of human coronaviruses known to cause respiratory tract symptoms. A co-infection with both viruses is rare, particularly in the United States. Case description: An 85-year-...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SMC MEDIA SRL
2025-01-01
|
| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/5068 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832540874114859008 |
|---|---|
| author | Laszlo Madaras Radean Anvari Claudia Schuchardt-Peet Abhinav Hoskote Rahul Kashyap |
| author_facet | Laszlo Madaras Radean Anvari Claudia Schuchardt-Peet Abhinav Hoskote Rahul Kashyap |
| author_sort | Laszlo Madaras |
| collection | DOAJ |
| description | Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus HKU1 (HCoV-HKU1) are two forms of human coronaviruses known to cause respiratory tract symptoms. A co-infection with both viruses is rare, particularly in the United States.
Case description: An 85-year-old male presented to the Emergency Department with recurrent falls, diarrhoea and cough, and whose viral panel was positive for both SARS-COV-2 and HCoV-HKU1. The patient developed bacterial pneumonia and was treated with antibacterial agents and glucocorticoids. His past medical history of atrial fibrillation required careful monitoring and subsequent discontinuation of remdesivir, a medication known to cause adverse cardiovascular effects in COVID-19 patients. The length of stay was also prolonged due to delirium and deconditioning. Ultimately, the patient required an urgent ablation followed by the placement of a permanent pacemaker, and anticoagulation therapy was initiated before discharge. The patient had a favourable outcome given the rarity of this case.
Discussion: COVID-19 patients co-infected with other human coronaviruses should be monitored for disease progression and superimposed bacterial infections. Providers should be cautious with the use of remdesivir in cases of co-infection and in severely ill COVID-19 patients who have a history of atrial fibrillation. |
| format | Article |
| id | doaj-art-f3e016158a13422e969a8a13e84156cb |
| institution | Kabale University |
| issn | 2284-2594 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj-art-f3e016158a13422e969a8a13e84156cb2025-02-04T13:37:20ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942025-01-0110.12890/2025_0050684603Co-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus HKU1 (HCoV-HKU1)Laszlo Madaras0Radean Anvari1Claudia Schuchardt-Peet2Abhinav Hoskote3Rahul Kashyap4Hospital Medicine, WellSpan Health Summit Health, Chambersburg, USACollege of Medicine, Drexel University, Philadelphia, USAHealth Information Science, WellSpan Health Summit Health, Chambersburg, USAInternal Medicine, WellSpan York Hospital, York, USACollege of Medicine, Drexel University, Philadelphia, USA; Internal Medicine, WellSpan York Hospital, York, USAIntroduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus HKU1 (HCoV-HKU1) are two forms of human coronaviruses known to cause respiratory tract symptoms. A co-infection with both viruses is rare, particularly in the United States. Case description: An 85-year-old male presented to the Emergency Department with recurrent falls, diarrhoea and cough, and whose viral panel was positive for both SARS-COV-2 and HCoV-HKU1. The patient developed bacterial pneumonia and was treated with antibacterial agents and glucocorticoids. His past medical history of atrial fibrillation required careful monitoring and subsequent discontinuation of remdesivir, a medication known to cause adverse cardiovascular effects in COVID-19 patients. The length of stay was also prolonged due to delirium and deconditioning. Ultimately, the patient required an urgent ablation followed by the placement of a permanent pacemaker, and anticoagulation therapy was initiated before discharge. The patient had a favourable outcome given the rarity of this case. Discussion: COVID-19 patients co-infected with other human coronaviruses should be monitored for disease progression and superimposed bacterial infections. Providers should be cautious with the use of remdesivir in cases of co-infection and in severely ill COVID-19 patients who have a history of atrial fibrillation.https://www.ejcrim.com/index.php/EJCRIM/article/view/5068sars-cov-2co-infection hcov-hku1covid-19 |
| spellingShingle | Laszlo Madaras Radean Anvari Claudia Schuchardt-Peet Abhinav Hoskote Rahul Kashyap Co-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus HKU1 (HCoV-HKU1) European Journal of Case Reports in Internal Medicine sars-cov-2 co-infection hcov-hku1 covid-19 |
| title | Co-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus HKU1 (HCoV-HKU1) |
| title_full | Co-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus HKU1 (HCoV-HKU1) |
| title_fullStr | Co-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus HKU1 (HCoV-HKU1) |
| title_full_unstemmed | Co-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus HKU1 (HCoV-HKU1) |
| title_short | Co-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus HKU1 (HCoV-HKU1) |
| title_sort | co infection with severe acute respiratory syndrome coronavirus 2 sars cov 2 and human coronavirus hku1 hcov hku1 |
| topic | sars-cov-2 co-infection hcov-hku1 covid-19 |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/5068 |
| work_keys_str_mv | AT laszlomadaras coinfectionwithsevereacuterespiratorysyndromecoronavirus2sarscov2andhumancoronavirushku1hcovhku1 AT radeananvari coinfectionwithsevereacuterespiratorysyndromecoronavirus2sarscov2andhumancoronavirushku1hcovhku1 AT claudiaschuchardtpeet coinfectionwithsevereacuterespiratorysyndromecoronavirus2sarscov2andhumancoronavirushku1hcovhku1 AT abhinavhoskote coinfectionwithsevereacuterespiratorysyndromecoronavirus2sarscov2andhumancoronavirushku1hcovhku1 AT rahulkashyap coinfectionwithsevereacuterespiratorysyndromecoronavirus2sarscov2andhumancoronavirushku1hcovhku1 |