Exosome‐Based Mitochondrial Delivery of circRNA mSCAR Alleviates Sepsis by Orchestrating Macrophage Activation

Exosome‐Based Mitochondrial Delivery of circRNA mSCAR Alleviates Sepsis by Orchestrating Macrophage Activation

Abstract Sepsis is one of the most common causes of death, which is closely related to the uncontrolled systemic inflammation. Dysregulation of M1 macrophage polarization is the primary contributor to serious inflammation. In this study, it is revealed that the murine homologue of circRNA SCAR (stea...

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Main Authors: Li Fan, Li Yao, Zhelong Li, Zhuo Wan, Wenqi Sun, Shuo Qiu, Wei Zhang, Dan Xiao, Liqiang Song, Guodong Yang, Yi Zhang, Mengying Wei, Xuekang Yang
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Advanced Science
Subjects:
circRNA mSCAR
exosome
macrophage polarization
mitochondrial targeted delivery
sepsis
Online Access:https://doi.org/10.1002/advs.202205692
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