Estimation of the glutathione system parameters depending on the variant of the disease course in patients with newly diagnosed pulmonary tuberculosis at coinfection tuberculosis/HIV
The aim was to estimate the thiol-disulfide compounds depending on the variant of disease course in tuberculosis/HIV co-infected patients with newly diagnosed tuberculosis (NDT/HIV). Materials and methods. The study involved 54 patients with NDT/HIV, who were treated in the clinic of Zaporizhzhia re...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2016-03-01
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| Series: | Zaporožskij Medicinskij Žurnal |
| Subjects: | |
| Online Access: | http://zmj.zsmu.edu.ua/article/view/69214/65152 |
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| Summary: | The aim was to estimate the thiol-disulfide compounds depending on the variant of disease course in tuberculosis/HIV co-infected patients with newly diagnosed tuberculosis (NDT/HIV). Materials and methods. The study involved 54 patients with NDT/HIV, who were treated in the clinic of Zaporizhzhia regional clinical tuberculosis dispensary during 2010 – 2014 (average age 37,8 ± 1,2 y), 41 (75,9%) men, 13 (24,1%) women. Focal tuberculosis was diagnosed in 5 cases (9,3%), infiltrative – in 25 (46,3%) cases, disseminated – in 24 (44,4%) cases. The control group included 32 healthy individuals – blood donors (average age 35,9 ± 2,5 y), 22 (68,7%) men, 10 women (31,3%). Patients depending on the results of the treatment were retrospectively were divided into 3 groups: 1 – 15 patients with positive dynamics, 2 - with progressive disease course without systemic inflammatory response syndrome (n=13), 3 –with progressive disease course with SIRS (n=26).
Results. Levels of aldehyde-phenylhydrazone in 2nd and 3rd groups were significantly higher than in control in 1,3 and 1,2 times accordingly (p˂0,01 for both values), in the 3rd group they were higher in 1,1 times than in group 1, p˂0,05. Ketone-phenylhydrazone levels were higher in all groups compared with the control, in the 3rd group patients they were 1,1 times higher than in group 1, p˂0,05. The malondialdehyde level in 3rd group patients was higher than other groups parameters in 1,4 times in comparison with 1-t (p˂0,005) and 1.2 times – with 2nd group (p˂0,05).
Conclusion. Imbalance in the “oxidants-antioxidants” system both through increased free radical peroxidation, and because of thiol-disulfide balance shifts at the disease progression was detected. |
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| ISSN: | 2306-4145 2310-1210 |