Development of Bullous Disease during Treatment of Pulmonary Marginal Zone B-Cell Lymphoma
We describe an unusual case of severe pulmonary bullous disease developing during treatment of marginal zone B-Cell lymphoma (MALT) involving the pulmonary parenchyma. The patient originally presented with pneumonia-like symptoms along with hemoptysis and was diagnosed with MALT lymphoma after a vid...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Pulmonology |
| Online Access: | http://dx.doi.org/10.1155/2012/146081 |
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| author | S. Ansari H. Dubaybo E. Levi B. A. Dubaybo |
| author_facet | S. Ansari H. Dubaybo E. Levi B. A. Dubaybo |
| author_sort | S. Ansari |
| collection | DOAJ |
| description | We describe an unusual case of severe pulmonary bullous disease developing during treatment of marginal zone B-Cell lymphoma (MALT) involving the pulmonary parenchyma. The patient originally presented with pneumonia-like symptoms along with hemoptysis and was diagnosed with MALT lymphoma after a video-assisted thoracic surgical (VATS) lung biopsy. Computed tomography (CT) of the chest at diagnosis revealed multiple opacities, but no bullous disease. During the ensuing 4 years, and while on chemotherapy for the MALT lymphoma, sequential CT and pulmonary function tests revealed the development of progressive bullous disease resulting in the replacement of large portions of the lung parenchyma with bilateral bullae. This complication is rare, has been reported only once before in a patient with concomitant amyloidosis, and may be related to activation of proteolytic enzymes by lymphoma cells or chemotherapeutic agents. |
| format | Article |
| id | doaj-art-f3be0706e2c44ff7852adffb7d460f03 |
| institution | Kabale University |
| issn | 2090-6846 2090-6854 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pulmonology |
| spelling | doaj-art-f3be0706e2c44ff7852adffb7d460f032025-02-03T01:10:48ZengWileyCase Reports in Pulmonology2090-68462090-68542012-01-01201210.1155/2012/146081146081Development of Bullous Disease during Treatment of Pulmonary Marginal Zone B-Cell LymphomaS. Ansari0H. Dubaybo1E. Levi2B. A. Dubaybo3Department of Internal Medicine, Wayne State University School of Medicine, 4201 St. Antoine, UHC-2E, Detroit, MI 48201, USADepartment of Internal Medicine, Wayne State University School of Medicine, 4201 St. Antoine, UHC-2E, Detroit, MI 48201, USAMedical Service, John D. Dingell VAMC, Detroit, MI 48201, USADepartment of Internal Medicine, Wayne State University School of Medicine, 4201 St. Antoine, UHC-2E, Detroit, MI 48201, USAWe describe an unusual case of severe pulmonary bullous disease developing during treatment of marginal zone B-Cell lymphoma (MALT) involving the pulmonary parenchyma. The patient originally presented with pneumonia-like symptoms along with hemoptysis and was diagnosed with MALT lymphoma after a video-assisted thoracic surgical (VATS) lung biopsy. Computed tomography (CT) of the chest at diagnosis revealed multiple opacities, but no bullous disease. During the ensuing 4 years, and while on chemotherapy for the MALT lymphoma, sequential CT and pulmonary function tests revealed the development of progressive bullous disease resulting in the replacement of large portions of the lung parenchyma with bilateral bullae. This complication is rare, has been reported only once before in a patient with concomitant amyloidosis, and may be related to activation of proteolytic enzymes by lymphoma cells or chemotherapeutic agents.http://dx.doi.org/10.1155/2012/146081 |
| spellingShingle | S. Ansari H. Dubaybo E. Levi B. A. Dubaybo Development of Bullous Disease during Treatment of Pulmonary Marginal Zone B-Cell Lymphoma Case Reports in Pulmonology |
| title | Development of Bullous Disease during Treatment of Pulmonary Marginal Zone B-Cell Lymphoma |
| title_full | Development of Bullous Disease during Treatment of Pulmonary Marginal Zone B-Cell Lymphoma |
| title_fullStr | Development of Bullous Disease during Treatment of Pulmonary Marginal Zone B-Cell Lymphoma |
| title_full_unstemmed | Development of Bullous Disease during Treatment of Pulmonary Marginal Zone B-Cell Lymphoma |
| title_short | Development of Bullous Disease during Treatment of Pulmonary Marginal Zone B-Cell Lymphoma |
| title_sort | development of bullous disease during treatment of pulmonary marginal zone b cell lymphoma |
| url | http://dx.doi.org/10.1155/2012/146081 |
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