Neurophysiology and Molecular Basis of Cognitive Behavioral Therapy for Patients with Insomnia: Implications for Non-Pharmacological Approaches
Cognitive behavioral therapy for insomnia (CBT-I) is a widely used psychological intervention known for its effectiveness in improving insomnia symptoms. However, the neurophysiological mechanisms underlying the cognitive-behavioral treatment of insomnia remain unclear. This narrative review aimed t...
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| Format: | Article |
| Language: | English |
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IMR Press
2024-10-01
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| Series: | Journal of Integrative Neuroscience |
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| Online Access: | https://www.imrpress.com/journal/JIN/23/11/10.31083/j.jin2311200 |
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| _version_ | 1846149139325255680 |
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| author | Guimei Zhang Sisi Wang Ping Ma Jiyang Pan |
| author_facet | Guimei Zhang Sisi Wang Ping Ma Jiyang Pan |
| author_sort | Guimei Zhang |
| collection | DOAJ |
| description | Cognitive behavioral therapy for insomnia (CBT-I) is a widely used psychological intervention known for its effectiveness in improving insomnia symptoms. However, the neurophysiological mechanisms underlying the cognitive-behavioral treatment of insomnia remain unclear. This narrative review aimed to elucidate the neurophysiological and molecular mechanisms of CBT-I, focusing on the fields of psychology, neurophysiology, neuroendocrinology, immunology, medical microbiology, epigenetics, neuroimaging and brain function. A comprehensive search was conducted using databases including: PubMed, Embase, PsycINFO and Web of Science, with customized search strategies tailored to each database that included controlled vocabulary and alternative synonyms. It revealed that CBT-I may have a beneficial effect on the central nervous system, boost the immune system, upregulate genes involved in interferon and antibody responses, enhance functional connectivity between the hippocampus and frontoparietal areas and increase cortical gray matter thickness. In conclusion, an integrated model is proposed that elucidates the mechanisms of CBT-I and offers a new direction for investigations into its neurophysiological mechanisms. |
| format | Article |
| id | doaj-art-f3b483695c8e43f096612284305d74cf |
| institution | Kabale University |
| issn | 0219-6352 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj-art-f3b483695c8e43f096612284305d74cf2024-11-30T02:43:58ZengIMR PressJournal of Integrative Neuroscience0219-63522024-10-01231120010.31083/j.jin2311200S0219-6352(24)00795-2Neurophysiology and Molecular Basis of Cognitive Behavioral Therapy for Patients with Insomnia: Implications for Non-Pharmacological ApproachesGuimei Zhang0Sisi Wang1Ping Ma2Jiyang Pan3Department of Psychiatry, Sleep Medicine Centre, First Affiliated Hospital of Jinan University, 510632 Guangzhou, Guangdong, ChinaDepartment of Psychiatry, Sleep Medicine Centre, First Affiliated Hospital of Jinan University, 510632 Guangzhou, Guangdong, ChinaDepartment of Psychiatry, Sleep Medicine Centre, First Affiliated Hospital of Jinan University, 510632 Guangzhou, Guangdong, ChinaDepartment of Psychiatry, Sleep Medicine Centre, First Affiliated Hospital of Jinan University, 510632 Guangzhou, Guangdong, ChinaCognitive behavioral therapy for insomnia (CBT-I) is a widely used psychological intervention known for its effectiveness in improving insomnia symptoms. However, the neurophysiological mechanisms underlying the cognitive-behavioral treatment of insomnia remain unclear. This narrative review aimed to elucidate the neurophysiological and molecular mechanisms of CBT-I, focusing on the fields of psychology, neurophysiology, neuroendocrinology, immunology, medical microbiology, epigenetics, neuroimaging and brain function. A comprehensive search was conducted using databases including: PubMed, Embase, PsycINFO and Web of Science, with customized search strategies tailored to each database that included controlled vocabulary and alternative synonyms. It revealed that CBT-I may have a beneficial effect on the central nervous system, boost the immune system, upregulate genes involved in interferon and antibody responses, enhance functional connectivity between the hippocampus and frontoparietal areas and increase cortical gray matter thickness. In conclusion, an integrated model is proposed that elucidates the mechanisms of CBT-I and offers a new direction for investigations into its neurophysiological mechanisms.https://www.imrpress.com/journal/JIN/23/11/10.31083/j.jin2311200insomnia disordercognitive behavioral therapy for insomniabrain functionneurophysiologyneuroendocrine |
| spellingShingle | Guimei Zhang Sisi Wang Ping Ma Jiyang Pan Neurophysiology and Molecular Basis of Cognitive Behavioral Therapy for Patients with Insomnia: Implications for Non-Pharmacological Approaches Journal of Integrative Neuroscience insomnia disorder cognitive behavioral therapy for insomnia brain function neurophysiology neuroendocrine |
| title | Neurophysiology and Molecular Basis of Cognitive Behavioral Therapy for Patients with Insomnia: Implications for Non-Pharmacological Approaches |
| title_full | Neurophysiology and Molecular Basis of Cognitive Behavioral Therapy for Patients with Insomnia: Implications for Non-Pharmacological Approaches |
| title_fullStr | Neurophysiology and Molecular Basis of Cognitive Behavioral Therapy for Patients with Insomnia: Implications for Non-Pharmacological Approaches |
| title_full_unstemmed | Neurophysiology and Molecular Basis of Cognitive Behavioral Therapy for Patients with Insomnia: Implications for Non-Pharmacological Approaches |
| title_short | Neurophysiology and Molecular Basis of Cognitive Behavioral Therapy for Patients with Insomnia: Implications for Non-Pharmacological Approaches |
| title_sort | neurophysiology and molecular basis of cognitive behavioral therapy for patients with insomnia implications for non pharmacological approaches |
| topic | insomnia disorder cognitive behavioral therapy for insomnia brain function neurophysiology neuroendocrine |
| url | https://www.imrpress.com/journal/JIN/23/11/10.31083/j.jin2311200 |
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