Kounis syndrome following COVID-19 vaccination: Clinical manifestations, mechanisms and management
Kounis syndrome is an acute coronary syndrome triggered by allergic mediators that induce coronary vasoconstriction and thrombosis, leading to further myocardial damage and anaphylactic shock. Kounis syndrome is also a rare but severe adverse reaction to the COVID-19 vaccine, a phenomenon that under...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2365496 |
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| author | Chengjie Zhao Ruoyan Lei Siyang Liu Mingyi Zhao |
| author_facet | Chengjie Zhao Ruoyan Lei Siyang Liu Mingyi Zhao |
| author_sort | Chengjie Zhao |
| collection | DOAJ |
| description | Kounis syndrome is an acute coronary syndrome triggered by allergic mediators that induce coronary vasoconstriction and thrombosis, leading to further myocardial damage and anaphylactic shock. Kounis syndrome is also a rare but severe adverse reaction to the COVID-19 vaccine, a phenomenon that underscores the importance of collecting and analyzing similar cases to improve treatment and prognosis. Through comprehensive searches of the Web of Science, Embase, and PubMed databases, this study aimed to gather detailed patient data on patients who developed Kounis syndrome after receiving the COVID-19 vaccine and to further investigate the possible underlying mechanisms using currently available studies. A total of 15 patients (8 females, 7 males) were found. We analyzed comprehensive patient data, including demographics, vaccination details, time of onset of illness after vaccination, clinical manifestations, treatment and outcomes, duration of illness, and relevant examination results. Analysis of these data combined with known allergy-related mechanisms indicated that, regardless of the vaccine type, the first dose of the vaccine was more likely to cause Kounis syndrome than subsequent doses. Therefore, early diagnosis and clinical symptomatic treatment are particularly crucial for managing the severity of Kounis syndrome and preventing further cardiac complications. Additionally, when an unusual and severe allergic reaction occurs within a few hours after vaccination, it is important to closely monitor the development of cardiac-related symptoms and prepare clinically for the potential onset of Kounis syndrome. |
| format | Article |
| id | doaj-art-f3a53138a59d4a679318dfbfb9cefa1f |
| institution | DOAJ |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-f3a53138a59d4a679318dfbfb9cefa1f2025-08-20T03:12:40ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2365496Kounis syndrome following COVID-19 vaccination: Clinical manifestations, mechanisms and managementChengjie Zhao0Ruoyan Lei1Siyang Liu2Mingyi Zhao3Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, ChinaDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, ChinaDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, ChinaDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, ChinaKounis syndrome is an acute coronary syndrome triggered by allergic mediators that induce coronary vasoconstriction and thrombosis, leading to further myocardial damage and anaphylactic shock. Kounis syndrome is also a rare but severe adverse reaction to the COVID-19 vaccine, a phenomenon that underscores the importance of collecting and analyzing similar cases to improve treatment and prognosis. Through comprehensive searches of the Web of Science, Embase, and PubMed databases, this study aimed to gather detailed patient data on patients who developed Kounis syndrome after receiving the COVID-19 vaccine and to further investigate the possible underlying mechanisms using currently available studies. A total of 15 patients (8 females, 7 males) were found. We analyzed comprehensive patient data, including demographics, vaccination details, time of onset of illness after vaccination, clinical manifestations, treatment and outcomes, duration of illness, and relevant examination results. Analysis of these data combined with known allergy-related mechanisms indicated that, regardless of the vaccine type, the first dose of the vaccine was more likely to cause Kounis syndrome than subsequent doses. Therefore, early diagnosis and clinical symptomatic treatment are particularly crucial for managing the severity of Kounis syndrome and preventing further cardiac complications. Additionally, when an unusual and severe allergic reaction occurs within a few hours after vaccination, it is important to closely monitor the development of cardiac-related symptoms and prepare clinically for the potential onset of Kounis syndrome.https://www.tandfonline.com/doi/10.1080/21645515.2024.2365496COVID-19vaccinesKounis syndromeallergic reactionclinical manifestation |
| spellingShingle | Chengjie Zhao Ruoyan Lei Siyang Liu Mingyi Zhao Kounis syndrome following COVID-19 vaccination: Clinical manifestations, mechanisms and management Human Vaccines & Immunotherapeutics COVID-19 vaccines Kounis syndrome allergic reaction clinical manifestation |
| title | Kounis syndrome following COVID-19 vaccination: Clinical manifestations, mechanisms and management |
| title_full | Kounis syndrome following COVID-19 vaccination: Clinical manifestations, mechanisms and management |
| title_fullStr | Kounis syndrome following COVID-19 vaccination: Clinical manifestations, mechanisms and management |
| title_full_unstemmed | Kounis syndrome following COVID-19 vaccination: Clinical manifestations, mechanisms and management |
| title_short | Kounis syndrome following COVID-19 vaccination: Clinical manifestations, mechanisms and management |
| title_sort | kounis syndrome following covid 19 vaccination clinical manifestations mechanisms and management |
| topic | COVID-19 vaccines Kounis syndrome allergic reaction clinical manifestation |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2365496 |
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