Promoting Motor Cortical Plasticity with Acute Aerobic Exercise: A Role for Cerebellar Circuits
Acute aerobic exercise facilitated long-term potentiation-like plasticity in the human primary motor cortex (M1). Here, we investigated the effect of acute aerobic exercise on cerebellar circuits, and their potential contribution to altered M1 plasticity in healthy individuals (age: 24.8±4.1 years)....
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/6797928 |
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| author | Cameron S. Mang Katlyn E. Brown Jason L. Neva Nicholas J. Snow Kristin L. Campbell Lara A. Boyd |
| author_facet | Cameron S. Mang Katlyn E. Brown Jason L. Neva Nicholas J. Snow Kristin L. Campbell Lara A. Boyd |
| author_sort | Cameron S. Mang |
| collection | DOAJ |
| description | Acute aerobic exercise facilitated long-term potentiation-like plasticity in the human primary motor cortex (M1). Here, we investigated the effect of acute aerobic exercise on cerebellar circuits, and their potential contribution to altered M1 plasticity in healthy individuals (age: 24.8±4.1 years). In Experiment 1, acute aerobic exercise reduced cerebellar inhibition (CBI) (n=10, p=0.01), elicited by dual-coil paired-pulse transcranial magnetic stimulation. In Experiment 2, we evaluated the facilitatory effects of aerobic exercise on responses to paired associative stimulation, delivered with a 25 ms (PAS25) or 21 ms (PAS21) interstimulus interval (n=16 per group). Increased M1 excitability evoked by PAS25, but not PAS21, relies on trans-cerebellar sensory pathways. The magnitude of the aerobic exercise effect on PAS response was not significantly different between PAS protocols (interaction effect: p=0.30); however, planned comparisons indicated that, relative to a period of rest, acute aerobic exercise enhanced the excitatory response to PAS25 (p=0.02), but not PAS21 (p=0.30). Thus, the results of these planned comparisons indirectly provide modest evidence that modulation of cerebellar circuits may contribute to exercise-induced increases in M1 plasticity. The findings have implications for developing aerobic exercise strategies to “prime” M1 plasticity for enhanced motor skill learning in applied settings. |
| format | Article |
| id | doaj-art-f38dbe3ca2ef42e1a48331e34ff21059 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-f38dbe3ca2ef42e1a48331e34ff210592025-08-20T03:25:47ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/67979286797928Promoting Motor Cortical Plasticity with Acute Aerobic Exercise: A Role for Cerebellar CircuitsCameron S. Mang0Katlyn E. Brown1Jason L. Neva2Nicholas J. Snow3Kristin L. Campbell4Lara A. Boyd5Graduate Program in Rehabilitation Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, CanadaGraduate Program in Rehabilitation Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, CanadaGraduate Program in Rehabilitation Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, CanadaGraduate Program in Rehabilitation Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, CanadaGraduate Program in Rehabilitation Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, CanadaGraduate Program in Rehabilitation Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, CanadaAcute aerobic exercise facilitated long-term potentiation-like plasticity in the human primary motor cortex (M1). Here, we investigated the effect of acute aerobic exercise on cerebellar circuits, and their potential contribution to altered M1 plasticity in healthy individuals (age: 24.8±4.1 years). In Experiment 1, acute aerobic exercise reduced cerebellar inhibition (CBI) (n=10, p=0.01), elicited by dual-coil paired-pulse transcranial magnetic stimulation. In Experiment 2, we evaluated the facilitatory effects of aerobic exercise on responses to paired associative stimulation, delivered with a 25 ms (PAS25) or 21 ms (PAS21) interstimulus interval (n=16 per group). Increased M1 excitability evoked by PAS25, but not PAS21, relies on trans-cerebellar sensory pathways. The magnitude of the aerobic exercise effect on PAS response was not significantly different between PAS protocols (interaction effect: p=0.30); however, planned comparisons indicated that, relative to a period of rest, acute aerobic exercise enhanced the excitatory response to PAS25 (p=0.02), but not PAS21 (p=0.30). Thus, the results of these planned comparisons indirectly provide modest evidence that modulation of cerebellar circuits may contribute to exercise-induced increases in M1 plasticity. The findings have implications for developing aerobic exercise strategies to “prime” M1 plasticity for enhanced motor skill learning in applied settings.http://dx.doi.org/10.1155/2016/6797928 |
| spellingShingle | Cameron S. Mang Katlyn E. Brown Jason L. Neva Nicholas J. Snow Kristin L. Campbell Lara A. Boyd Promoting Motor Cortical Plasticity with Acute Aerobic Exercise: A Role for Cerebellar Circuits Neural Plasticity |
| title | Promoting Motor Cortical Plasticity with Acute Aerobic Exercise: A Role for Cerebellar Circuits |
| title_full | Promoting Motor Cortical Plasticity with Acute Aerobic Exercise: A Role for Cerebellar Circuits |
| title_fullStr | Promoting Motor Cortical Plasticity with Acute Aerobic Exercise: A Role for Cerebellar Circuits |
| title_full_unstemmed | Promoting Motor Cortical Plasticity with Acute Aerobic Exercise: A Role for Cerebellar Circuits |
| title_short | Promoting Motor Cortical Plasticity with Acute Aerobic Exercise: A Role for Cerebellar Circuits |
| title_sort | promoting motor cortical plasticity with acute aerobic exercise a role for cerebellar circuits |
| url | http://dx.doi.org/10.1155/2016/6797928 |
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