Neovascular glaucoma as a complication of proton therapy for uveal melanoma
<p> I.E. Panova<sup>1,2,3,</sup> E.M. Svistunova<sup>1</sup>, N.A. Vorobyov<sup>2,4</sup>, E.V. Samkovich<sup>1</sup>, N.I. Martynova<sup>4</sup>, A.A. Bykhovsky<sup>1</sup> </p> <p> <sup>1</sup>...
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| Format: | Article |
| Language: | Russian |
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Prime-Media
2024-12-01
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| Series: | РМЖ "Клиническая офтальмология" |
| Online Access: | http://clinopht.com/upload/iblock/219/9jqdrxxuu4qu5rl11wvqebr39r7bm717.pdf |
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| author | I.E. Panova E.M. Svistunova N.A. Vorobyov E.V. Samkovich N.I. Martynova A.A. Bykhovsky |
| author_facet | I.E. Panova E.M. Svistunova N.A. Vorobyov E.V. Samkovich N.I. Martynova A.A. Bykhovsky |
| author_sort | I.E. Panova |
| collection | DOAJ |
| description | <p>
I.E. Panova<sup>1,2,3,</sup> E.M. Svistunova<sup>1</sup>, N.A. Vorobyov<sup>2,4</sup>, E.V. Samkovich<sup>1</sup>, N.I. Martynova<sup>4</sup>, A.A. Bykhovsky<sup>1</sup>
</p>
<p>
<sup>1</sup>Saint Petersburg Branch of the S. Fyodorov Eye Microsurgery Federal State Institution, St. Petersburg, Russian Federation
</p>
<p>
<sup>2</sup>St. Petersburg State University, St. Petersburg, Russian Federation
</p>
<p>
<sup>3</sup>North West State Medical University named after I.I. Mechnikov, St. Petersburg, Russian Federation
</p>
<p>
<sup>4</sup>Medical and Diagnostic Center of the International Institute of Biological Systems named after Berezin Sergei, St. Petersburg, Russian Federation
</p>
<p>
<b>Aim: </b>to evaluate possible predictors of neovascular glaucoma (NVG) in patients with uveal melanoma (UM) after pencil-beam scanning proton therapy (PT).
</p>
<p>
<b>Patients and Methods: </b>29 UM patients (30 eyes; age: 23–87 years) received a course of hypofractionated PT at a total dose of 49 Gy in 7 fractions (BED 0.6=620 Gy; EQD2=143 Gy). After the therapy, radiation-related complications developed in 26 patients at various times, and in some cases they affected multiple systems. Ocular hypertension was reported in 13 patients, and NVG developed in 9 of them. NVG predictors were evaluated in groups of NVG patients (Study Group/SG 1) and non-NVG ones (SG 2) with a ≥6-month follow-up (n=22) after the end of the PT course.
</p>
<p>
<b>Results: the </b>NVG group demonstrated lower best corrected visual acuity (BCVA) and total visual field loss (along 8 meridians, in degrees) values, as well as pre-treatment Bruch's membrane rupture and more advanced stage of the disease significantly (p<0.05) more often than the non-NVG group.
</p>
<p>
<b>Conclusion:</b> the study revealed some possible predictors of neovascular glaucoma development that should be considered to select patients for pencil-beam scanning PT in terms of organ preservation UM treatment. Further study of the issue in a larger patient cohort and a longer follow-up will provide identification of additional risk factors for NVG and generation of a mathematical prediction model of the complication development.
</p>
<p>
<b>Keywords: </b>choroidal melanoma, proton therapy, uveal melanoma, ocular oncology, neovascular glaucoma, radiation-related complications.
</p>
<p>
<b>For citation:</b> Panova I.E., Svistunova E.M., Vorobyov N.A., Samkovich E.V., Martynova N.I., Bykhovsky A.A. Neovascular glaucoma as a complication of proton therapy for uveal melanoma. Russian Journal of Clinical Ophthalmology. 2024;24(4):185–192 (in Russ.). DOI: 10.32364/2311-7729-2024-24-4-4
</p> |
| format | Article |
| id | doaj-art-f3808ccab3294c678cd90d6eef986aa1 |
| institution | Kabale University |
| issn | 2311-7729 2619-1571 |
| language | Russian |
| publishDate | 2024-12-01 |
| publisher | Prime-Media |
| record_format | Article |
| series | РМЖ "Клиническая офтальмология" |
| spelling | doaj-art-f3808ccab3294c678cd90d6eef986aa12025-01-16T09:39:38ZrusPrime-MediaРМЖ "Клиническая офтальмология"2311-77292619-15712024-12-0124431798Neovascular glaucoma as a complication of proton therapy for uveal melanomaI.E. Panova0E.M. Svistunova1N.A. Vorobyov2E.V. Samkovich3N.I. Martynova4A.A. Bykhovsky5Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399<p> I.E. Panova<sup>1,2,3,</sup> E.M. Svistunova<sup>1</sup>, N.A. Vorobyov<sup>2,4</sup>, E.V. Samkovich<sup>1</sup>, N.I. Martynova<sup>4</sup>, A.A. Bykhovsky<sup>1</sup> </p> <p> <sup>1</sup>Saint Petersburg Branch of the S. Fyodorov Eye Microsurgery Federal State Institution, St. Petersburg, Russian Federation </p> <p> <sup>2</sup>St. Petersburg State University, St. Petersburg, Russian Federation </p> <p> <sup>3</sup>North West State Medical University named after I.I. Mechnikov, St. Petersburg, Russian Federation </p> <p> <sup>4</sup>Medical and Diagnostic Center of the International Institute of Biological Systems named after Berezin Sergei, St. Petersburg, Russian Federation </p> <p> <b>Aim: </b>to evaluate possible predictors of neovascular glaucoma (NVG) in patients with uveal melanoma (UM) after pencil-beam scanning proton therapy (PT). </p> <p> <b>Patients and Methods: </b>29 UM patients (30 eyes; age: 23–87 years) received a course of hypofractionated PT at a total dose of 49 Gy in 7 fractions (BED 0.6=620 Gy; EQD2=143 Gy). After the therapy, radiation-related complications developed in 26 patients at various times, and in some cases they affected multiple systems. Ocular hypertension was reported in 13 patients, and NVG developed in 9 of them. NVG predictors were evaluated in groups of NVG patients (Study Group/SG 1) and non-NVG ones (SG 2) with a ≥6-month follow-up (n=22) after the end of the PT course. </p> <p> <b>Results: the </b>NVG group demonstrated lower best corrected visual acuity (BCVA) and total visual field loss (along 8 meridians, in degrees) values, as well as pre-treatment Bruch's membrane rupture and more advanced stage of the disease significantly (p<0.05) more often than the non-NVG group. </p> <p> <b>Conclusion:</b> the study revealed some possible predictors of neovascular glaucoma development that should be considered to select patients for pencil-beam scanning PT in terms of organ preservation UM treatment. Further study of the issue in a larger patient cohort and a longer follow-up will provide identification of additional risk factors for NVG and generation of a mathematical prediction model of the complication development. </p> <p> <b>Keywords: </b>choroidal melanoma, proton therapy, uveal melanoma, ocular oncology, neovascular glaucoma, radiation-related complications. </p> <p> <b>For citation:</b> Panova I.E., Svistunova E.M., Vorobyov N.A., Samkovich E.V., Martynova N.I., Bykhovsky A.A. Neovascular glaucoma as a complication of proton therapy for uveal melanoma. Russian Journal of Clinical Ophthalmology. 2024;24(4):185–192 (in Russ.). DOI: 10.32364/2311-7729-2024-24-4-4 </p>http://clinopht.com/upload/iblock/219/9jqdrxxuu4qu5rl11wvqebr39r7bm717.pdf |
| spellingShingle | I.E. Panova E.M. Svistunova N.A. Vorobyov E.V. Samkovich N.I. Martynova A.A. Bykhovsky Neovascular glaucoma as a complication of proton therapy for uveal melanoma РМЖ "Клиническая офтальмология" |
| title | Neovascular glaucoma as a complication of proton therapy for uveal melanoma |
| title_full | Neovascular glaucoma as a complication of proton therapy for uveal melanoma |
| title_fullStr | Neovascular glaucoma as a complication of proton therapy for uveal melanoma |
| title_full_unstemmed | Neovascular glaucoma as a complication of proton therapy for uveal melanoma |
| title_short | Neovascular glaucoma as a complication of proton therapy for uveal melanoma |
| title_sort | neovascular glaucoma as a complication of proton therapy for uveal melanoma |
| url | http://clinopht.com/upload/iblock/219/9jqdrxxuu4qu5rl11wvqebr39r7bm717.pdf |
| work_keys_str_mv | AT iepanova neovascularglaucomaasacomplicationofprotontherapyforuvealmelanoma AT emsvistunova neovascularglaucomaasacomplicationofprotontherapyforuvealmelanoma AT navorobyov neovascularglaucomaasacomplicationofprotontherapyforuvealmelanoma AT evsamkovich neovascularglaucomaasacomplicationofprotontherapyforuvealmelanoma AT nimartynova neovascularglaucomaasacomplicationofprotontherapyforuvealmelanoma AT aabykhovsky neovascularglaucomaasacomplicationofprotontherapyforuvealmelanoma |