Neutrophil-Mediated Gastrointestinal Injury
Inflammatory diseases of the gastrointestinal tract are frequently characterized by a dense infiltration of neutrophils in the lamina propria and the subsequent transepithelial migration of these cells into the lumen. While the neutrophil plays an essential role in defending against bacterial infect...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1998-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1998/398384 |
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| _version_ | 1849468630452928512 |
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| author | Susan N Elliott John L Wallace |
| author_facet | Susan N Elliott John L Wallace |
| author_sort | Susan N Elliott |
| collection | DOAJ |
| description | Inflammatory diseases of the gastrointestinal tract are frequently characterized by a dense infiltration of neutrophils in the lamina propria and the subsequent transepithelial migration of these cells into the lumen. While the neutrophil plays an essential role in defending against bacterial infection, it can also cause significant injury to the host tissue. The evidence for a role of neutrophils in producing significant tissue injury in a number of gastrointestinal disorders and the mechanisms through which neutrophils produce tissue injury are reviewed. Furthermore, the evidence that some commonly used anti-inflammatory drugs produce beneficial effects through modulation of neutrophil extravasation or activation is reviewed. |
| format | Article |
| id | doaj-art-f37affc5fa6947ea9fe224846909dc88 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-f37affc5fa6947ea9fe224846909dc882025-08-20T03:25:47ZengWileyCanadian Journal of Gastroenterology0835-79001998-01-0112855956810.1155/1998/398384Neutrophil-Mediated Gastrointestinal InjurySusan N Elliott0John L Wallace1Inflammation Research Unit, Faculty of Medicine, University of Calgary, Calgary, Alberta, CanadaInflammation Research Unit, Faculty of Medicine, University of Calgary, Calgary, Alberta, CanadaInflammatory diseases of the gastrointestinal tract are frequently characterized by a dense infiltration of neutrophils in the lamina propria and the subsequent transepithelial migration of these cells into the lumen. While the neutrophil plays an essential role in defending against bacterial infection, it can also cause significant injury to the host tissue. The evidence for a role of neutrophils in producing significant tissue injury in a number of gastrointestinal disorders and the mechanisms through which neutrophils produce tissue injury are reviewed. Furthermore, the evidence that some commonly used anti-inflammatory drugs produce beneficial effects through modulation of neutrophil extravasation or activation is reviewed.http://dx.doi.org/10.1155/1998/398384 |
| spellingShingle | Susan N Elliott John L Wallace Neutrophil-Mediated Gastrointestinal Injury Canadian Journal of Gastroenterology |
| title | Neutrophil-Mediated Gastrointestinal Injury |
| title_full | Neutrophil-Mediated Gastrointestinal Injury |
| title_fullStr | Neutrophil-Mediated Gastrointestinal Injury |
| title_full_unstemmed | Neutrophil-Mediated Gastrointestinal Injury |
| title_short | Neutrophil-Mediated Gastrointestinal Injury |
| title_sort | neutrophil mediated gastrointestinal injury |
| url | http://dx.doi.org/10.1155/1998/398384 |
| work_keys_str_mv | AT susannelliott neutrophilmediatedgastrointestinalinjury AT johnlwallace neutrophilmediatedgastrointestinalinjury |