Adrenal Lymphangioma Masquerading as a Catecholamine Producing Tumor

Objective. To report the unusual case of an adrenal lymphangioma presenting in a patient with an adrenal cystic lesion and biochemical testing concerning for pheochromocytoma. The pertinent diagnostic and imaging features of adrenal lymphangiomas are reviewed. Methods. We describe a 59-year-old pati...

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Main Authors: Israel Hodish, Lindsay Schmidt, Andreas G. Moraitis
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:Case Reports in Endocrinology
Online Access:http://dx.doi.org/10.1155/2015/380151
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author Israel Hodish
Lindsay Schmidt
Andreas G. Moraitis
author_facet Israel Hodish
Lindsay Schmidt
Andreas G. Moraitis
author_sort Israel Hodish
collection DOAJ
description Objective. To report the unusual case of an adrenal lymphangioma presenting in a patient with an adrenal cystic lesion and biochemical testing concerning for pheochromocytoma. The pertinent diagnostic and imaging features of adrenal lymphangiomas are reviewed. Methods. We describe a 59-year-old patient who presented with hyperhidrosis and a 2.2 by 2.2 cm left adrenal nodule. Biochemical evaluation revealed elevated plasma-free normetanephrine, urine normetanephrine, urine vanillylmandelic acid, and urine norepinephrine levels. Elevated plasma norepinephrine levels were not suppressed appropriately with clonidine administration. Results. Given persistent concern for pheochromocytoma, the patient underwent adrenalectomy. The final pathology was consistent with adrenal lymphangioma. Conclusions. Lymphangiomas are benign vascular lesions that can very rarely occur in the adrenal gland. Imaging findings are generally consistent with a cyst but are nonspecific. Excluding malignancy in patients presenting with adrenal cysts can be difficult. Despite its benign nature, the diagnosis of adrenal lymphangioma may ultimately require pathology.
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spelling doaj-art-f37ad4ba90b64464b1070bff8adbd75f2025-02-03T06:07:00ZengWileyCase Reports in Endocrinology2090-65012090-651X2015-01-01201510.1155/2015/380151380151Adrenal Lymphangioma Masquerading as a Catecholamine Producing TumorIsrael Hodish0Lindsay Schmidt1Andreas G. Moraitis2Division of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USADepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USACorcept Therapeutics, Menlo Park, CA 94025, USAObjective. To report the unusual case of an adrenal lymphangioma presenting in a patient with an adrenal cystic lesion and biochemical testing concerning for pheochromocytoma. The pertinent diagnostic and imaging features of adrenal lymphangiomas are reviewed. Methods. We describe a 59-year-old patient who presented with hyperhidrosis and a 2.2 by 2.2 cm left adrenal nodule. Biochemical evaluation revealed elevated plasma-free normetanephrine, urine normetanephrine, urine vanillylmandelic acid, and urine norepinephrine levels. Elevated plasma norepinephrine levels were not suppressed appropriately with clonidine administration. Results. Given persistent concern for pheochromocytoma, the patient underwent adrenalectomy. The final pathology was consistent with adrenal lymphangioma. Conclusions. Lymphangiomas are benign vascular lesions that can very rarely occur in the adrenal gland. Imaging findings are generally consistent with a cyst but are nonspecific. Excluding malignancy in patients presenting with adrenal cysts can be difficult. Despite its benign nature, the diagnosis of adrenal lymphangioma may ultimately require pathology.http://dx.doi.org/10.1155/2015/380151
spellingShingle Israel Hodish
Lindsay Schmidt
Andreas G. Moraitis
Adrenal Lymphangioma Masquerading as a Catecholamine Producing Tumor
Case Reports in Endocrinology
title Adrenal Lymphangioma Masquerading as a Catecholamine Producing Tumor
title_full Adrenal Lymphangioma Masquerading as a Catecholamine Producing Tumor
title_fullStr Adrenal Lymphangioma Masquerading as a Catecholamine Producing Tumor
title_full_unstemmed Adrenal Lymphangioma Masquerading as a Catecholamine Producing Tumor
title_short Adrenal Lymphangioma Masquerading as a Catecholamine Producing Tumor
title_sort adrenal lymphangioma masquerading as a catecholamine producing tumor
url http://dx.doi.org/10.1155/2015/380151
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AT lindsayschmidt adrenallymphangiomamasqueradingasacatecholamineproducingtumor
AT andreasgmoraitis adrenallymphangiomamasqueradingasacatecholamineproducingtumor