Effectiveness Evaluation of Levamisole, Albendazole, Ivermectin, and Vernonia amygdalina in West African Dwarf Goats
Anthelmintic drug resistance has led to the search for alternatives in controlling helminth infections. Fifty West African Dwarf goats without history of anthelmintic treatment were divided equally into five groups. Group A was treated with ivermectin injection subcutaneously, group B with levamisol...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/706824 |
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| author | Oyeduntan A. Adediran Emmanuel C. Uwalaka |
| author_facet | Oyeduntan A. Adediran Emmanuel C. Uwalaka |
| author_sort | Oyeduntan A. Adediran |
| collection | DOAJ |
| description | Anthelmintic drug resistance has led to the search for alternatives in controlling helminth infections. Fifty West African Dwarf goats without history of anthelmintic treatment were divided equally into five groups. Group A was treated with ivermectin injection subcutaneously, group B with levamisole subcutaneously, group C with albendazole orally, and group D with aqueous extract of Vernonia amygdalina and group E was untreated control. Faecal samples were collected before treatment from each animal and larval culture was carried out. Faecal egg count reduction (FECR) test was carried out for each group and the data analysed using FECR version 4 to calculate percent reduction in faecal egg count. Predominant helminth infections from larval culture were Haemonchus contortus (70%), Trichostrongylus spp. (61%), and Oesophagostomum spp. (56%). Mixed infection was present in all the animals. From the FECR test Vernonia amygdalina extract was more effective against helminths (100%), compared to ivermectin 96%, levamisole 96%, and albendazole 99%. The lower 95% confidence limit was 89 for ivermectin and levamisole and 91 for albendazole. There is low resistance to ivermectin and levamisole and susceptibility to albendazole while V. amygdalina has great potentials that could be explored for the treatment of helminth diseases in goats. |
| format | Article |
| id | doaj-art-f36cea1fd7b0433281b2ae40828d4bd8 |
| institution | Kabale University |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-f36cea1fd7b0433281b2ae40828d4bd82025-02-03T01:11:17ZengWileyJournal of Parasitology Research2090-00232090-00312015-01-01201510.1155/2015/706824706824Effectiveness Evaluation of Levamisole, Albendazole, Ivermectin, and Vernonia amygdalina in West African Dwarf GoatsOyeduntan A. Adediran0Emmanuel C. Uwalaka1Department of Veterinary Microbiology and Parasitology, University of Ibadan, Ibadan, Oyo, NigeriaDepartment of Veterinary Microbiology and Parasitology, University of Ibadan, Ibadan, Oyo, NigeriaAnthelmintic drug resistance has led to the search for alternatives in controlling helminth infections. Fifty West African Dwarf goats without history of anthelmintic treatment were divided equally into five groups. Group A was treated with ivermectin injection subcutaneously, group B with levamisole subcutaneously, group C with albendazole orally, and group D with aqueous extract of Vernonia amygdalina and group E was untreated control. Faecal samples were collected before treatment from each animal and larval culture was carried out. Faecal egg count reduction (FECR) test was carried out for each group and the data analysed using FECR version 4 to calculate percent reduction in faecal egg count. Predominant helminth infections from larval culture were Haemonchus contortus (70%), Trichostrongylus spp. (61%), and Oesophagostomum spp. (56%). Mixed infection was present in all the animals. From the FECR test Vernonia amygdalina extract was more effective against helminths (100%), compared to ivermectin 96%, levamisole 96%, and albendazole 99%. The lower 95% confidence limit was 89 for ivermectin and levamisole and 91 for albendazole. There is low resistance to ivermectin and levamisole and susceptibility to albendazole while V. amygdalina has great potentials that could be explored for the treatment of helminth diseases in goats.http://dx.doi.org/10.1155/2015/706824 |
| spellingShingle | Oyeduntan A. Adediran Emmanuel C. Uwalaka Effectiveness Evaluation of Levamisole, Albendazole, Ivermectin, and Vernonia amygdalina in West African Dwarf Goats Journal of Parasitology Research |
| title | Effectiveness Evaluation of Levamisole, Albendazole, Ivermectin, and Vernonia amygdalina in West African Dwarf Goats |
| title_full | Effectiveness Evaluation of Levamisole, Albendazole, Ivermectin, and Vernonia amygdalina in West African Dwarf Goats |
| title_fullStr | Effectiveness Evaluation of Levamisole, Albendazole, Ivermectin, and Vernonia amygdalina in West African Dwarf Goats |
| title_full_unstemmed | Effectiveness Evaluation of Levamisole, Albendazole, Ivermectin, and Vernonia amygdalina in West African Dwarf Goats |
| title_short | Effectiveness Evaluation of Levamisole, Albendazole, Ivermectin, and Vernonia amygdalina in West African Dwarf Goats |
| title_sort | effectiveness evaluation of levamisole albendazole ivermectin and vernonia amygdalina in west african dwarf goats |
| url | http://dx.doi.org/10.1155/2015/706824 |
| work_keys_str_mv | AT oyeduntanaadediran effectivenessevaluationoflevamisolealbendazoleivermectinandvernoniaamygdalinainwestafricandwarfgoats AT emmanuelcuwalaka effectivenessevaluationoflevamisolealbendazoleivermectinandvernoniaamygdalinainwestafricandwarfgoats |