High HDL-C and high LDL-C are risk factors of pterygium in a population-based cross-sectional study in Southern China: the Dongguan Eye Study
Objectives To investigate the relationship between serum lipids and pterygium in a large-scale rural population aged 40 years or older from Southern China.Study design The Dongguan Eye Study was a cross-sectional population-based study from September 2011 to February 2012.Setting The area was set in...
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BMJ Publishing Group
2022-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e058649.full |
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| author | Liang Zhang Min Zhang Ying Cui Lixin Zhang Guanrong Zhang Qingyang Liu Haike Guo Qianli Meng Siwen Zang Chun-Han Lo Yanlei Chen Jin Zeng |
| author_facet | Liang Zhang Min Zhang Ying Cui Lixin Zhang Guanrong Zhang Qingyang Liu Haike Guo Qianli Meng Siwen Zang Chun-Han Lo Yanlei Chen Jin Zeng |
| author_sort | Liang Zhang |
| collection | DOAJ |
| description | Objectives To investigate the relationship between serum lipids and pterygium in a large-scale rural population aged 40 years or older from Southern China.Study design The Dongguan Eye Study was a cross-sectional population-based study from September 2011 to February 2012.Setting The area was set in the rural area of Dongguan, Southern China.Participants Adult rural population aged 40 or older.Methods Participants underwent physical, haematological and ophthalmic examinations.Primary and secondary outcome measures The frequency and risk factors of pterygium.Results A total of 11 357 participants were eligible for inclusion and 8952 (78.8%) participants were enrolled for the systemic and ophthalmic examinations. The prevalence of pterygium was 17.3% after adjusting the sex and age distribution, 22.0% in participants with hypercholesterolaemia (total cholesterol ≥6.22 mmol/L (240 mg/dL)) and 21.8% in those with low-density lipoprotein-cholesterol (LDL-C) ≥4.14 mmol/L (160 mg/dL), respectively. After adjusting for multiple confounding factors, higher level of high-density lipoprotein-cholesterol (HDL-C) (OR: 1.23, 95% CI: 1.06 to 1.41) and LDL-C (OR: 1.13, 95% CI: 1.06 to 1.20) were positively associated with the risk of pterygium. The ORs for HDL-C or LDL-C with pterygium were significantly greater in participants aged 40–49 years than those aged 50 years or above (P for interaction <0.001). Furthermore, increased HDL-C showed greater association with pterygium in normal body mass index (BMI) group compared with overweight group (P for interaction=0.002).Conclusion Increased HDL-C and LDL-C are risk factors of pterygium, especially in people <50 years or those with normal BMI level. Strict control of HDL-C and LDL-C may be a new prevention method in reducing the risk of pterygium. |
| format | Article |
| id | doaj-art-f35de59c1ebe45ff9e795efdca8ad227 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-f35de59c1ebe45ff9e795efdca8ad2272025-01-24T18:40:09ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-058649High HDL-C and high LDL-C are risk factors of pterygium in a population-based cross-sectional study in Southern China: the Dongguan Eye StudyLiang Zhang0Min Zhang1Ying Cui2Lixin Zhang3Guanrong Zhang4Qingyang Liu5Haike Guo6Qianli Meng7Siwen Zang8Chun-Han Lo9Yanlei Chen10Jin Zeng11Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People`s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, ChinaRevivMed Inc., Cambridge, MA, USALady Davis Institute for Medical Research Centre for Clinical Epidemiology, Montreal, Québec, Canada3Magee-Womens Research Institute, Pittsburgh, PA, USA5 Information and Statistics Center, Guangdong Provincial People`s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China2 Department of Ophthalmology, Dongguan People`s Hospital, Dongguan, ChinaDepartment of Ophthalmology, Shanghai Peace Eye Hospital, Shanghai, ChinaDepartment of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People`s Hospital, Guangzhou, Guangdong, China3 Department of Ophthalmology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Chinaresident physicianGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People`s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, ChinaGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People`s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, ChinaObjectives To investigate the relationship between serum lipids and pterygium in a large-scale rural population aged 40 years or older from Southern China.Study design The Dongguan Eye Study was a cross-sectional population-based study from September 2011 to February 2012.Setting The area was set in the rural area of Dongguan, Southern China.Participants Adult rural population aged 40 or older.Methods Participants underwent physical, haematological and ophthalmic examinations.Primary and secondary outcome measures The frequency and risk factors of pterygium.Results A total of 11 357 participants were eligible for inclusion and 8952 (78.8%) participants were enrolled for the systemic and ophthalmic examinations. The prevalence of pterygium was 17.3% after adjusting the sex and age distribution, 22.0% in participants with hypercholesterolaemia (total cholesterol ≥6.22 mmol/L (240 mg/dL)) and 21.8% in those with low-density lipoprotein-cholesterol (LDL-C) ≥4.14 mmol/L (160 mg/dL), respectively. After adjusting for multiple confounding factors, higher level of high-density lipoprotein-cholesterol (HDL-C) (OR: 1.23, 95% CI: 1.06 to 1.41) and LDL-C (OR: 1.13, 95% CI: 1.06 to 1.20) were positively associated with the risk of pterygium. The ORs for HDL-C or LDL-C with pterygium were significantly greater in participants aged 40–49 years than those aged 50 years or above (P for interaction <0.001). Furthermore, increased HDL-C showed greater association with pterygium in normal body mass index (BMI) group compared with overweight group (P for interaction=0.002).Conclusion Increased HDL-C and LDL-C are risk factors of pterygium, especially in people <50 years or those with normal BMI level. Strict control of HDL-C and LDL-C may be a new prevention method in reducing the risk of pterygium.https://bmjopen.bmj.com/content/12/6/e058649.full |
| spellingShingle | Liang Zhang Min Zhang Ying Cui Lixin Zhang Guanrong Zhang Qingyang Liu Haike Guo Qianli Meng Siwen Zang Chun-Han Lo Yanlei Chen Jin Zeng High HDL-C and high LDL-C are risk factors of pterygium in a population-based cross-sectional study in Southern China: the Dongguan Eye Study BMJ Open |
| title | High HDL-C and high LDL-C are risk factors of pterygium in a population-based cross-sectional study in Southern China: the Dongguan Eye Study |
| title_full | High HDL-C and high LDL-C are risk factors of pterygium in a population-based cross-sectional study in Southern China: the Dongguan Eye Study |
| title_fullStr | High HDL-C and high LDL-C are risk factors of pterygium in a population-based cross-sectional study in Southern China: the Dongguan Eye Study |
| title_full_unstemmed | High HDL-C and high LDL-C are risk factors of pterygium in a population-based cross-sectional study in Southern China: the Dongguan Eye Study |
| title_short | High HDL-C and high LDL-C are risk factors of pterygium in a population-based cross-sectional study in Southern China: the Dongguan Eye Study |
| title_sort | high hdl c and high ldl c are risk factors of pterygium in a population based cross sectional study in southern china the dongguan eye study |
| url | https://bmjopen.bmj.com/content/12/6/e058649.full |
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