Early Recurrence of Hepatocellular Carcinoma in Patients without Microscopic Vascular Invasion: Clinicopathological Characteristics and Risk Factors
Hanh Thi Tuyet Ngo,1 Duy Duc Nguyen,2 Minh-Xuan Dang,2 Thao Thi Phuong Doan,2 Truc Thanh Thai3 1Department of Embryology - Pathology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam; 2Department of Pathology, University Medical Center Ho Chi Minh City, Ho Chi Minh...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-06-01
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| Series: | Journal of Hepatocellular Carcinoma |
| Subjects: | |
| Online Access: | https://www.dovepress.com/early-recurrence-of-hepatocellular-carcinoma-in-patients-without-micro-peer-reviewed-fulltext-article-JHC |
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| Summary: | Hanh Thi Tuyet Ngo,1 Duy Duc Nguyen,2 Minh-Xuan Dang,2 Thao Thi Phuong Doan,2 Truc Thanh Thai3 1Department of Embryology - Pathology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam; 2Department of Pathology, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam; 3Department of Medical Statistics and Informatics, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, VietnamCorrespondence: Duy Duc Nguyen, Department of Pathology, University Medical Center Ho Chi Minh City, 215 Hong Bang Street, Ward 11, District 5, Ho Chi Minh City, 700000, Vietnam, Tel +84904974422, Email duy.nd1@umc.edu.vnPurpose: Early recurrence of hepatocellular carcinoma (HCC) is not uniformly associated with microscopic vascular invasion (MVI). This study aims to identify the clinical and pathological factors associated with early recurrence in HCC patients without MVI.Methods: A retrospective cohort study was conducted on 69 patients who underwent hepatectomy for HCC at the University Medical Center Ho Chi Minh city. All patients were microscopically confirmed as MVI-negative. Clinical and subclinical data, along with tumor recurrence within 24 months post-surgery were collected. Microscopic features of both tumor and non-tumor liver tissue were assessed using Hematoxylin-Eosin-stained slides.Results: The majority of patients were male (78.3%) and had cirrhosis (72.5%). The early recurrence rate was 31.9%, with most recurrences occurring between 6- and 18-month post-surgery. Independent factors for early tumor recurrence included preoperative treatment with Transarterial Chemoembolization (TACE) or Radiofrequency Ablation (RFA) (HR = 8.63, 95% CI = 1.45– 51.38), tumor size > 5 cm (HR = 3.82, 95% CI = 1.17– 12.42), and HCV infection (HR = 4.61, 95% CI = 1.41– 15.1).Conclusion: The pathogenesis and pattern of early tumor recurrence in MVI-negative HCC differ from that in MVI-positive cases. Identifying risk factors, such as HCV infection, tumor size, and preoperative locoregional therapy, may aid in optimizing treatment strategies and postoperative surveillance.Keywords: hepatocellular carcinoma, microvascular invasion, early recurrence, risk factor, clinical characteristics, pathological characteristics |
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| ISSN: | 2253-5969 |