Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations
Individuals with sickle cell disease (SCD) present both chronic and acute inflammatory events. The TGF-β pathway is known to play a role in immune response, angiogenesis, inflammation, hematopoiesis, vascular inflammation, and cell proliferation. Polymorphisms in the transforming growth factor-beta...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/3185015 |
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| author | Rayra P. Santiago Camylla V. B. Figueiredo Luciana M. Fiuza Sètondji C. M. A. Yahouédéhou Rodrigo M. Oliveira Milena M. Aleluia Suellen P. Carvalho Cleverson A. Fonseca Valma M. L. Nascimento Larissa C. Rocha Caroline C. Guarda Marilda S. Gonçalves |
| author_facet | Rayra P. Santiago Camylla V. B. Figueiredo Luciana M. Fiuza Sètondji C. M. A. Yahouédéhou Rodrigo M. Oliveira Milena M. Aleluia Suellen P. Carvalho Cleverson A. Fonseca Valma M. L. Nascimento Larissa C. Rocha Caroline C. Guarda Marilda S. Gonçalves |
| author_sort | Rayra P. Santiago |
| collection | DOAJ |
| description | Individuals with sickle cell disease (SCD) present both chronic and acute inflammatory events. The TGF-β pathway is known to play a role in immune response, angiogenesis, inflammation, hematopoiesis, vascular inflammation, and cell proliferation. Polymorphisms in the transforming growth factor-beta receptor 3 (TGFBR3) gene have been linked to several inflammatory diseases. This study investigated associations between two TGFBR3 haplotypes and classical laboratory parameters, as well as clinical manifestations, in SCD. We found that individuals with the GG haplotype presented higher levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides, non-HDL cholesterol, total proteins, and globulin than individuals with non-GG haplotypes. In addition, the GG haplotype was associated with a previous history of pneumonia. Individuals with the CGG haplotype presented increased plateletcrit, TC, LDL-C levels, and non-HDL cholesterol. The CCG haplotype was also associated with a previous history of pneumonia. Our findings suggest that individuals with the GG and CGG haplotypes of TGFBR3 present important alterations in lipid profile. |
| format | Article |
| id | doaj-art-f35c42e4663747afa18f399a54be5dfd |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-f35c42e4663747afa18f399a54be5dfd2025-08-20T02:21:46ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/31850153185015Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical ManifestationsRayra P. Santiago0Camylla V. B. Figueiredo1Luciana M. Fiuza2Sètondji C. M. A. Yahouédéhou3Rodrigo M. Oliveira4Milena M. Aleluia5Suellen P. Carvalho6Cleverson A. Fonseca7Valma M. L. Nascimento8Larissa C. Rocha9Caroline C. Guarda10Marilda S. Gonçalves11Laboratório de Investigação em Genética e Hematologia Translacional, Instituto Gonçalo Moniz, FIOCRUZ-BA, Salvador 40296-710, BrazilLaboratório de Investigação em Genética e Hematologia Translacional, Instituto Gonçalo Moniz, FIOCRUZ-BA, Salvador 40296-710, BrazilLaboratório de Investigação em Genética e Hematologia Translacional, Instituto Gonçalo Moniz, FIOCRUZ-BA, Salvador 40296-710, BrazilLaboratório de Investigação em Genética e Hematologia Translacional, Instituto Gonçalo Moniz, FIOCRUZ-BA, Salvador 40296-710, BrazilLaboratório de Investigação em Genética e Hematologia Translacional, Instituto Gonçalo Moniz, FIOCRUZ-BA, Salvador 40296-710, BrazilDepartamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, UESC, Ilhéus 45662-900, BrazilLaboratório de Investigação em Genética e Hematologia Translacional, Instituto Gonçalo Moniz, FIOCRUZ-BA, Salvador 40296-710, BrazilUniversidade Federal da Bahia, UFBA, Salvador 40170-110, BrazilFundação de Hematologia e Hemoterapia do Estado da Bahia, HEMOBA, Salvador 40286-240, BrazilFundação de Hematologia e Hemoterapia do Estado da Bahia, HEMOBA, Salvador 40286-240, BrazilLaboratório de Investigação em Genética e Hematologia Translacional, Instituto Gonçalo Moniz, FIOCRUZ-BA, Salvador 40296-710, BrazilLaboratório de Investigação em Genética e Hematologia Translacional, Instituto Gonçalo Moniz, FIOCRUZ-BA, Salvador 40296-710, BrazilIndividuals with sickle cell disease (SCD) present both chronic and acute inflammatory events. The TGF-β pathway is known to play a role in immune response, angiogenesis, inflammation, hematopoiesis, vascular inflammation, and cell proliferation. Polymorphisms in the transforming growth factor-beta receptor 3 (TGFBR3) gene have been linked to several inflammatory diseases. This study investigated associations between two TGFBR3 haplotypes and classical laboratory parameters, as well as clinical manifestations, in SCD. We found that individuals with the GG haplotype presented higher levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides, non-HDL cholesterol, total proteins, and globulin than individuals with non-GG haplotypes. In addition, the GG haplotype was associated with a previous history of pneumonia. Individuals with the CGG haplotype presented increased plateletcrit, TC, LDL-C levels, and non-HDL cholesterol. The CCG haplotype was also associated with a previous history of pneumonia. Our findings suggest that individuals with the GG and CGG haplotypes of TGFBR3 present important alterations in lipid profile.http://dx.doi.org/10.1155/2020/3185015 |
| spellingShingle | Rayra P. Santiago Camylla V. B. Figueiredo Luciana M. Fiuza Sètondji C. M. A. Yahouédéhou Rodrigo M. Oliveira Milena M. Aleluia Suellen P. Carvalho Cleverson A. Fonseca Valma M. L. Nascimento Larissa C. Rocha Caroline C. Guarda Marilda S. Gonçalves Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations Mediators of Inflammation |
| title | Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations |
| title_full | Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations |
| title_fullStr | Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations |
| title_full_unstemmed | Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations |
| title_short | Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations |
| title_sort | transforming growth factor beta receptor 3 haplotypes in sickle cell disease are associated with lipid profile and clinical manifestations |
| url | http://dx.doi.org/10.1155/2020/3185015 |
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