CD4 T-Cell-Independent Antibody Response Reduces Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral Loads
Enterovirus 71 (EV71) has induced fatal encephalitis in hundreds of thousands of infants and young children in the Asia-Pacific region since the past decade. Lymphocyte and antibody responses have been suspected to aggravate EV71-induced neurological symptoms, so anti-inflammatory agents have been u...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/580696 |
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| author | Li-Chiu Wang Chia-Min Kao Pin Ling Ih-Jen Su Tung-Miao Chang Shun-Hua Chen |
| author_facet | Li-Chiu Wang Chia-Min Kao Pin Ling Ih-Jen Su Tung-Miao Chang Shun-Hua Chen |
| author_sort | Li-Chiu Wang |
| collection | DOAJ |
| description | Enterovirus 71 (EV71) has induced fatal encephalitis in hundreds of thousands of infants and young children in the Asia-Pacific region since the past decade. Lymphocyte and antibody responses have been suspected to aggravate EV71-induced neurological symptoms, so anti-inflammatory agents have been used to treat patients with neurological symptoms. In the present study, we found that mice deficient in CD4+ T cells were resistant to EV71 infection as wild-type mice, whereas mice deficient in B cells were highly susceptible to viral infection. Compensation of CD4 T-cell function by other immune cells was not likely, because wild-type mice depleted of CD4+ T cells were also resistant to viral infection. Infected CD4 T-cell-deficient mice produced virus-specific neutralizing antibodies, IgM and IgG. Moreover, adoptive transfer of the virus-specific antibody produced by infected CD4 T-cell-deficient mice protected B-cell-deficient mice from infection by reducing tissue viral loads. Collectively, our results show that the CD4 T-cell-independent antibody response promotes the survival of EV71-infected mice and suggest great potential for the use of vaccines and neutralizing antibodies to reduce fatal symptoms in patients. |
| format | Article |
| id | doaj-art-f357d7ef8c2f4371bf1e6fed0884a60e |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-f357d7ef8c2f4371bf1e6fed0884a60e2025-02-03T06:06:37ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/580696580696CD4 T-Cell-Independent Antibody Response Reduces Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral LoadsLi-Chiu Wang0Chia-Min Kao1Pin Ling2Ih-Jen Su3Tung-Miao Chang4Shun-Hua Chen5Institute of Basic Medical Sciences, Medical College, National Cheng Kung University, Tainan 701, TaiwanDepartment of Microbiology and Immunology, Medical College, National Cheng Kung University, Tainan 701, TaiwanDepartment of Microbiology and Immunology, Medical College, National Cheng Kung University, Tainan 701, TaiwanNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan 701, TaiwanStatistical Analysis Laboratory, Department of International Business Management, Tainan University of Technology, Tainan 701, TaiwanInstitute of Basic Medical Sciences, Medical College, National Cheng Kung University, Tainan 701, TaiwanEnterovirus 71 (EV71) has induced fatal encephalitis in hundreds of thousands of infants and young children in the Asia-Pacific region since the past decade. Lymphocyte and antibody responses have been suspected to aggravate EV71-induced neurological symptoms, so anti-inflammatory agents have been used to treat patients with neurological symptoms. In the present study, we found that mice deficient in CD4+ T cells were resistant to EV71 infection as wild-type mice, whereas mice deficient in B cells were highly susceptible to viral infection. Compensation of CD4 T-cell function by other immune cells was not likely, because wild-type mice depleted of CD4+ T cells were also resistant to viral infection. Infected CD4 T-cell-deficient mice produced virus-specific neutralizing antibodies, IgM and IgG. Moreover, adoptive transfer of the virus-specific antibody produced by infected CD4 T-cell-deficient mice protected B-cell-deficient mice from infection by reducing tissue viral loads. Collectively, our results show that the CD4 T-cell-independent antibody response promotes the survival of EV71-infected mice and suggest great potential for the use of vaccines and neutralizing antibodies to reduce fatal symptoms in patients.http://dx.doi.org/10.1155/2012/580696 |
| spellingShingle | Li-Chiu Wang Chia-Min Kao Pin Ling Ih-Jen Su Tung-Miao Chang Shun-Hua Chen CD4 T-Cell-Independent Antibody Response Reduces Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral Loads Clinical and Developmental Immunology |
| title | CD4 T-Cell-Independent Antibody Response Reduces Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral Loads |
| title_full | CD4 T-Cell-Independent Antibody Response Reduces Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral Loads |
| title_fullStr | CD4 T-Cell-Independent Antibody Response Reduces Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral Loads |
| title_full_unstemmed | CD4 T-Cell-Independent Antibody Response Reduces Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral Loads |
| title_short | CD4 T-Cell-Independent Antibody Response Reduces Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral Loads |
| title_sort | cd4 t cell independent antibody response reduces enterovirus 71 lethality in mice by decreasing tissue viral loads |
| url | http://dx.doi.org/10.1155/2012/580696 |
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