Trends and Clinical Implications of Pediatric Pulmonary Function After Hematopoietic Stem Cell Transplantation: A Systematic Review

ABSTRACT Background and Aims Hematopoietic stem cell transplantation (HSCT) is a key therapeutic approach for pediatric patients with hematologic and non‐hematologic disorders. However, post‐transplant pulmonary complications remain a significant cause of morbidity and mortality. Pulmonary Function...

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Main Authors: Xiaowei Zhao, Yuqi Zhao, Guoyu Ding, Xue Li, Xiaoyue Zhang, Yanli Leng, Hongmei Wang
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Health Science Reports
Subjects:
Online Access:https://doi.org/10.1002/hsr2.70365
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author Xiaowei Zhao
Yuqi Zhao
Guoyu Ding
Xue Li
Xiaoyue Zhang
Yanli Leng
Hongmei Wang
author_facet Xiaowei Zhao
Yuqi Zhao
Guoyu Ding
Xue Li
Xiaoyue Zhang
Yanli Leng
Hongmei Wang
author_sort Xiaowei Zhao
collection DOAJ
description ABSTRACT Background and Aims Hematopoietic stem cell transplantation (HSCT) is a key therapeutic approach for pediatric patients with hematologic and non‐hematologic disorders. However, post‐transplant pulmonary complications remain a significant cause of morbidity and mortality. Pulmonary Function Tests (PFTs) are essential for the early detection of pulmonary dysfunction, yet their application in pediatric HSCT recipients has yielded inconsistent results. This review aims to assess the variations in pulmonary function post‐HSCT and explore their clinical implications for pediatric patients. Methods A systematic review was conducted by analyzing studies published between 2000 and 2024, sourced from PubMed, Web of Science, CNKI, and Wan Fang databases. The review included cohort studies, randomized controlled trials, and case‐control studies that assessed pulmonary function using standardized PFTs. Results Pulmonary dysfunction, particularly obstructive and restrictive ventilatory disorders, is common in pediatric HSCT recipients. Significant changes in PFT parameters, such as FEV1/FVC ratio and FEF25‐75%, were observed. However, trends in post‐transplant pulmonary function vary due to factors such as pre‐transplant lung conditions, patient age, and treatment protocols. Innovative diagnostic methods, such as parametric response mapping (PRM) and multiple breath washout (MBW), show promise in enhancing early detection and management of pulmonary complications. Conclusion Monitoring pulmonary function is critical for the early identification of complications in pediatric HSCT recipients. Although standardized clinical guidelines are available, variability in PFT trends underscores the need for more refined diagnostic tools. Advanced diagnostic methods, like PRM and MBW, may improve early detection and help optimize the management of pulmonary dysfunction, ultimately improving long‐term outcomes for pediatric patients.
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spelling doaj-art-f354642fb07d4ffbbe81de3f7043a7f22025-01-29T03:42:39ZengWileyHealth Science Reports2398-88352025-01-0181n/an/a10.1002/hsr2.70365Trends and Clinical Implications of Pediatric Pulmonary Function After Hematopoietic Stem Cell Transplantation: A Systematic ReviewXiaowei Zhao0Yuqi Zhao1Guoyu Ding2Xue Li3Xiaoyue Zhang4Yanli Leng5Hongmei Wang6Department of Pediatrics The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital jinan Shandong ChinaDepartment of Pediatrics The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital jinan Shandong ChinaDepartment of Pediatrics The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital jinan Shandong ChinaDepartment of Pediatrics The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital jinan Shandong ChinaDepartment of Pediatrics The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital jinan Shandong ChinaDepartment of Pediatrics The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital jinan Shandong ChinaDepartment of Pediatrics The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital jinan Shandong ChinaABSTRACT Background and Aims Hematopoietic stem cell transplantation (HSCT) is a key therapeutic approach for pediatric patients with hematologic and non‐hematologic disorders. However, post‐transplant pulmonary complications remain a significant cause of morbidity and mortality. Pulmonary Function Tests (PFTs) are essential for the early detection of pulmonary dysfunction, yet their application in pediatric HSCT recipients has yielded inconsistent results. This review aims to assess the variations in pulmonary function post‐HSCT and explore their clinical implications for pediatric patients. Methods A systematic review was conducted by analyzing studies published between 2000 and 2024, sourced from PubMed, Web of Science, CNKI, and Wan Fang databases. The review included cohort studies, randomized controlled trials, and case‐control studies that assessed pulmonary function using standardized PFTs. Results Pulmonary dysfunction, particularly obstructive and restrictive ventilatory disorders, is common in pediatric HSCT recipients. Significant changes in PFT parameters, such as FEV1/FVC ratio and FEF25‐75%, were observed. However, trends in post‐transplant pulmonary function vary due to factors such as pre‐transplant lung conditions, patient age, and treatment protocols. Innovative diagnostic methods, such as parametric response mapping (PRM) and multiple breath washout (MBW), show promise in enhancing early detection and management of pulmonary complications. Conclusion Monitoring pulmonary function is critical for the early identification of complications in pediatric HSCT recipients. Although standardized clinical guidelines are available, variability in PFT trends underscores the need for more refined diagnostic tools. Advanced diagnostic methods, like PRM and MBW, may improve early detection and help optimize the management of pulmonary dysfunction, ultimately improving long‐term outcomes for pediatric patients.https://doi.org/10.1002/hsr2.70365diagnostic techniquesgraft‐versus‐host diseasehematopoietic stem cell transplantationpulmonary function testsrespiratory tract diseasestransplantation‐related complications
spellingShingle Xiaowei Zhao
Yuqi Zhao
Guoyu Ding
Xue Li
Xiaoyue Zhang
Yanli Leng
Hongmei Wang
Trends and Clinical Implications of Pediatric Pulmonary Function After Hematopoietic Stem Cell Transplantation: A Systematic Review
Health Science Reports
diagnostic techniques
graft‐versus‐host disease
hematopoietic stem cell transplantation
pulmonary function tests
respiratory tract diseases
transplantation‐related complications
title Trends and Clinical Implications of Pediatric Pulmonary Function After Hematopoietic Stem Cell Transplantation: A Systematic Review
title_full Trends and Clinical Implications of Pediatric Pulmonary Function After Hematopoietic Stem Cell Transplantation: A Systematic Review
title_fullStr Trends and Clinical Implications of Pediatric Pulmonary Function After Hematopoietic Stem Cell Transplantation: A Systematic Review
title_full_unstemmed Trends and Clinical Implications of Pediatric Pulmonary Function After Hematopoietic Stem Cell Transplantation: A Systematic Review
title_short Trends and Clinical Implications of Pediatric Pulmonary Function After Hematopoietic Stem Cell Transplantation: A Systematic Review
title_sort trends and clinical implications of pediatric pulmonary function after hematopoietic stem cell transplantation a systematic review
topic diagnostic techniques
graft‐versus‐host disease
hematopoietic stem cell transplantation
pulmonary function tests
respiratory tract diseases
transplantation‐related complications
url https://doi.org/10.1002/hsr2.70365
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