Development and In Vitro Characterization of [<sup>3</sup>H]GMC-058 as Radioligand for Imaging Parkinsonian-Related Proteinopathies

Development and In Vitro Characterization of [<sup>3</sup>H]GMC-058 as Radioligand for Imaging Parkinsonian-Related Proteinopathies

The molecular imaging of α-synuclein (α-syn) pathology in Parkinson’s disease (PD) and related movement disorders is a clinically unmet need. The aim of this study was to discover and characterize in vitro a radioligand for imaging α-syn pathology. A library of 78 small molecules was developed and s...

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Main Authors: Andrea Varrone, Vasco C. Sousa, Manolo Mugnaini, Sandra Biesinger, Gunnar Nordvall, Lee Kingston, Ileana Guzzetti, Charles S. Elmore, Dan Sunnemark, Dinahlee Saturnino Guarino, Sjoerd J. Finnema, Magnus Schou
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
in vitro assay
neurodegeneration
proteinopathy
Lewy bodies
Online Access:https://www.mdpi.com/2073-4409/14/12/869
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