Layer-Specific Strain Analysis in Patients with Dilated Cardiomyopathy
Background/Objectives: This study aimed to evaluate layer-specific strain according to etiology and assess whether subtle changes in longitudinal and circumferential layer strain are involved in predicting cardiac mortality during a two-year follow-up in patients with dilated cardiomyopathy admitted...
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MDPI AG
2024-12-01
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| Online Access: | https://www.mdpi.com/2227-9059/13/1/11 |
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| author | Despina-Manuela Toader Alina Paraschiv Georgică Târtea Gabriela Tiucu Mihai Chițu Raluca Stănișor Oana Mirea |
| author_facet | Despina-Manuela Toader Alina Paraschiv Georgică Târtea Gabriela Tiucu Mihai Chițu Raluca Stănișor Oana Mirea |
| author_sort | Despina-Manuela Toader |
| collection | DOAJ |
| description | Background/Objectives: This study aimed to evaluate layer-specific strain according to etiology and assess whether subtle changes in longitudinal and circumferential layer strain are involved in predicting cardiac mortality during a two-year follow-up in patients with dilated cardiomyopathy admitted with heart failure decompensation. Methods: 97 patients with dilated cardiomyopathy and a left ventricle ejection fraction ≤ 40% were recruited, 51 with ischemic and 46 with nonischemic etiologies. Conventional and two-dimensional speckle-tracking echocardiography (2D-STE) were conducted in dilated cardiomyopathy patients with a compensated phase of heart failure before discharge. Layer-specific longitudinal and circumferential strain was assessed from the endocardium, mid-myocardium, and epicardium by two-dimensional (2D) speckle-tracking echocardiography. The gradient between the endocardium and epicardium was calculated. Results: Patients with nonischemic etiology of dilated cardiomyopathy presented smaller values of global and layer strain than patients in the ischemic group. GLS, GLSend, GLSend-GLSepi, CSPMend, CSPMend-CSPMepi, CSAP, CSAPend, and CSAPend-CSAPepi were the parameters with statistically significant decreased values in non-survivors compared with survivors. In multivariate analysis, only CSPMend showed an independent value in predicting mortality at two-year follow-up. Receiver operator curve analysis provided CSPMend of −10.8% as a cut-off value with a sensitivity of 80% and specificity of 61.05% in identifying the dilated cardiomyopathy and heart failure patients with a risk of death at two-year follow-up. Conclusions: GLS, GCS, and layer-specific strain analysis showed decreased values in nonischemic compared with ischemic dilated cardiomyopathy and also in non-survivors compared with survivors. CSPMend was the most sensitive strain parameter to identify patients with increased mortality risk at two-year follow-up. |
| format | Article |
| id | doaj-art-f345cec7818d41229de9b0d87141604d |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-f345cec7818d41229de9b0d87141604d2025-01-24T13:23:42ZengMDPI AGBiomedicines2227-90592024-12-011311110.3390/biomedicines13010011Layer-Specific Strain Analysis in Patients with Dilated CardiomyopathyDespina-Manuela Toader0Alina Paraschiv1Georgică Târtea2Gabriela Tiucu3Mihai Chițu4Raluca Stănișor5Oana Mirea6EuroEchoLab, Craiova Cardiology Center, Emergency Hospital Craiova, 200642 Craiova, RomaniaFilantropy Hospital Craiova, 200143 Craiova, RomaniaInterventional Cardiology, Cardiology Department, Emergency Hospital Craiova, 200642 Craiova, RomaniaCentre Hospitalier Sud Francilien, 91100 Corbeil Essonnes, FranceEuroEchoLab, Craiova Cardiology Center, Emergency Hospital Craiova, 200642 Craiova, RomaniaEuroEchoLab, Craiova Cardiology Center, Emergency Hospital Craiova, 200642 Craiova, RomaniaEuroEchoLab, Craiova Cardiology Center, Emergency Hospital Craiova, 200642 Craiova, RomaniaBackground/Objectives: This study aimed to evaluate layer-specific strain according to etiology and assess whether subtle changes in longitudinal and circumferential layer strain are involved in predicting cardiac mortality during a two-year follow-up in patients with dilated cardiomyopathy admitted with heart failure decompensation. Methods: 97 patients with dilated cardiomyopathy and a left ventricle ejection fraction ≤ 40% were recruited, 51 with ischemic and 46 with nonischemic etiologies. Conventional and two-dimensional speckle-tracking echocardiography (2D-STE) were conducted in dilated cardiomyopathy patients with a compensated phase of heart failure before discharge. Layer-specific longitudinal and circumferential strain was assessed from the endocardium, mid-myocardium, and epicardium by two-dimensional (2D) speckle-tracking echocardiography. The gradient between the endocardium and epicardium was calculated. Results: Patients with nonischemic etiology of dilated cardiomyopathy presented smaller values of global and layer strain than patients in the ischemic group. GLS, GLSend, GLSend-GLSepi, CSPMend, CSPMend-CSPMepi, CSAP, CSAPend, and CSAPend-CSAPepi were the parameters with statistically significant decreased values in non-survivors compared with survivors. In multivariate analysis, only CSPMend showed an independent value in predicting mortality at two-year follow-up. Receiver operator curve analysis provided CSPMend of −10.8% as a cut-off value with a sensitivity of 80% and specificity of 61.05% in identifying the dilated cardiomyopathy and heart failure patients with a risk of death at two-year follow-up. Conclusions: GLS, GCS, and layer-specific strain analysis showed decreased values in nonischemic compared with ischemic dilated cardiomyopathy and also in non-survivors compared with survivors. CSPMend was the most sensitive strain parameter to identify patients with increased mortality risk at two-year follow-up.https://www.mdpi.com/2227-9059/13/1/11dilated cardiomyopathylayer-specific strain analysisoutcome |
| spellingShingle | Despina-Manuela Toader Alina Paraschiv Georgică Târtea Gabriela Tiucu Mihai Chițu Raluca Stănișor Oana Mirea Layer-Specific Strain Analysis in Patients with Dilated Cardiomyopathy Biomedicines dilated cardiomyopathy layer-specific strain analysis outcome |
| title | Layer-Specific Strain Analysis in Patients with Dilated Cardiomyopathy |
| title_full | Layer-Specific Strain Analysis in Patients with Dilated Cardiomyopathy |
| title_fullStr | Layer-Specific Strain Analysis in Patients with Dilated Cardiomyopathy |
| title_full_unstemmed | Layer-Specific Strain Analysis in Patients with Dilated Cardiomyopathy |
| title_short | Layer-Specific Strain Analysis in Patients with Dilated Cardiomyopathy |
| title_sort | layer specific strain analysis in patients with dilated cardiomyopathy |
| topic | dilated cardiomyopathy layer-specific strain analysis outcome |
| url | https://www.mdpi.com/2227-9059/13/1/11 |
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