Review of gut-kidney crosstalk in acute kidney injury
With the characteristics of high incidence, high mortality, high health-economic cost and social burden, acute kidney injury（AKI）has become a worldwide public health problem.Currently there is no established pharmacotherapy for AKI.Emerging studies have proposed that gut-kidney axis crosstalk may pl...
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| Main Authors: | , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2021-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57904135&Fpath=home&index=0 |
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| Summary: | With the characteristics of high incidence, high mortality, high health-economic cost and social burden, acute kidney injury（AKI）has become a worldwide public health problem.Currently there is no established pharmacotherapy for AKI.Emerging studies have proposed that gut-kidney axis crosstalk may play an important role in the occurrence and development of AKI and its distal non-renal organ injury/dysfunction.And it is expected to become a new promising target for intervention.This review summarized the bidirectional role of intestinal-renal axis in AKI,including secondary intestinal barrier injury, gut-derived immune response, inflammation disorders, intestinal-related host immunomodulation and homeostasis of gut microbiome.The possible mechanisms were explore for intervening AKI based upon intestinal-renal axis from the perspective of achieving multi-system balance by adjusting intestinal homeostasis.The latest research advances were discussed for providing new ideas and methods for improving the prognosis of AKI. |
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| ISSN: | 1671-2390 |