Alleviation of DSS-induced colitis by Meconopsis polysaccharides correlated with reduced PI3K/AKT signaling and gut microbiome diversity

Alleviation of DSS-induced colitis by Meconopsis polysaccharides correlated with reduced PI3K/AKT signaling and gut microbiome diversity

IntroductionInflammatory bowel disease (IBD) is a recurrent gastrointestinal disorder that significantly impacts patients’ quality of life globally. This study focuses on the polysaccharides (MP) extracted from Meconopsis integrifolia, to investigate its role in alleviating DSS (dextran sulfate sodi...

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Bibliographic Details
Main Authors: Jun Dai, Weidong Wang, Fangfang He, Yujuan Wang, Denglang Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
Meconopsis polysaccharides
DSS-induced colitis
PI3K/Akt signaling pathway
gut microbiome diversity
short-chain fatty acids
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1459668/full
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