Amnion Epithelial Cells as a Candidate Therapy for Acute and Chronic Lung Injury
Acute and chronic lung injury represents a major and growing global burden of disease. For many of these lung diseases, the damage is irreparable, exhausting the host’s ability to regenerate new lung, and current therapies are simply supportive rather than restorative. Cell-based therapies offer the...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2012/709763 |
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| _version_ | 1832560010652024832 |
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| author | Ryan J. Hodges Rebecca Lim Graham Jenkin Euan M. Wallace |
| author_facet | Ryan J. Hodges Rebecca Lim Graham Jenkin Euan M. Wallace |
| author_sort | Ryan J. Hodges |
| collection | DOAJ |
| description | Acute and chronic lung injury represents a major and growing global burden of disease. For many of these lung diseases, the damage is irreparable, exhausting the host’s ability to regenerate new lung, and current therapies are simply supportive rather than restorative. Cell-based therapies offer the promise of tissue regeneration for many organs. In this paper, we examine the potential application of amnion epithelial cells, derived from the term placenta, to lung regeneration. We discuss their unique properties of plasticity and immunomodulation, reviewing the experimental evidence that amnion epithelial cells can prevent and repair lung injury, offering the potential to be applied to both neonatal, childhood, and adult lung disease. It is amazing to suggest that the placenta may offer renewed life after birth as well as securing new life before. |
| format | Article |
| id | doaj-art-f33df6dbe65a422984cf8903bd54faec |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-f33df6dbe65a422984cf8903bd54faec2025-02-03T01:28:40ZengWileyStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/709763709763Amnion Epithelial Cells as a Candidate Therapy for Acute and Chronic Lung InjuryRyan J. Hodges0Rebecca Lim1Graham Jenkin2Euan M. Wallace3The Ritchie Centre, Monash Institute of Medical Research and Department of Obstetrics and Gynaecology, Southern Clinical School and Monash Medical Centre, Monash University, 246 Clayton Road, Clayton, VIC 3168, AustraliaThe Ritchie Centre, Monash Institute of Medical Research and Department of Obstetrics and Gynaecology, Southern Clinical School and Monash Medical Centre, Monash University, 246 Clayton Road, Clayton, VIC 3168, AustraliaThe Ritchie Centre, Monash Institute of Medical Research and Department of Obstetrics and Gynaecology, Southern Clinical School and Monash Medical Centre, Monash University, 246 Clayton Road, Clayton, VIC 3168, AustraliaThe Ritchie Centre, Monash Institute of Medical Research and Department of Obstetrics and Gynaecology, Southern Clinical School and Monash Medical Centre, Monash University, 246 Clayton Road, Clayton, VIC 3168, AustraliaAcute and chronic lung injury represents a major and growing global burden of disease. For many of these lung diseases, the damage is irreparable, exhausting the host’s ability to regenerate new lung, and current therapies are simply supportive rather than restorative. Cell-based therapies offer the promise of tissue regeneration for many organs. In this paper, we examine the potential application of amnion epithelial cells, derived from the term placenta, to lung regeneration. We discuss their unique properties of plasticity and immunomodulation, reviewing the experimental evidence that amnion epithelial cells can prevent and repair lung injury, offering the potential to be applied to both neonatal, childhood, and adult lung disease. It is amazing to suggest that the placenta may offer renewed life after birth as well as securing new life before.http://dx.doi.org/10.1155/2012/709763 |
| spellingShingle | Ryan J. Hodges Rebecca Lim Graham Jenkin Euan M. Wallace Amnion Epithelial Cells as a Candidate Therapy for Acute and Chronic Lung Injury Stem Cells International |
| title | Amnion Epithelial Cells as a Candidate Therapy for Acute and Chronic Lung Injury |
| title_full | Amnion Epithelial Cells as a Candidate Therapy for Acute and Chronic Lung Injury |
| title_fullStr | Amnion Epithelial Cells as a Candidate Therapy for Acute and Chronic Lung Injury |
| title_full_unstemmed | Amnion Epithelial Cells as a Candidate Therapy for Acute and Chronic Lung Injury |
| title_short | Amnion Epithelial Cells as a Candidate Therapy for Acute and Chronic Lung Injury |
| title_sort | amnion epithelial cells as a candidate therapy for acute and chronic lung injury |
| url | http://dx.doi.org/10.1155/2012/709763 |
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