The increasing incidence and mortality of bacteremia in Denmark from 2010 to 2022: a population-based nationwide cohort study
ObjectivesAn increasing incidence of positive blood cultures has been reported in several countries. This represents an important challenge for public health due to the large number of hospital admissions with high mortality among these patients. This study aims to characterize the epidemiology and...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1502893/full |
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| author | Ram B. Dessau Ram B. Dessau Ram B. Dessau Christian Østergaard Andersen Christian Østergaard Andersen John Coia Svend Ellermann-Eriksen Sophie Gubbels Thøger Gorm Jensen Jenny Dahl Knudsen Jonas Kähler Steen Lomborg Lisbeth Lützen Marc Trunjer Kusk Nielsen Bente Scharvik Olesen Mette Pinholt Flemming Scheutz Kirstine Kobberøe Søgaard Marianne Voldstedlund Kåre Mølbak Kåre Mølbak |
| author_facet | Ram B. Dessau Ram B. Dessau Ram B. Dessau Christian Østergaard Andersen Christian Østergaard Andersen John Coia Svend Ellermann-Eriksen Sophie Gubbels Thøger Gorm Jensen Jenny Dahl Knudsen Jonas Kähler Steen Lomborg Lisbeth Lützen Marc Trunjer Kusk Nielsen Bente Scharvik Olesen Mette Pinholt Flemming Scheutz Kirstine Kobberøe Søgaard Marianne Voldstedlund Kåre Mølbak Kåre Mølbak |
| author_sort | Ram B. Dessau |
| collection | DOAJ |
| description | ObjectivesAn increasing incidence of positive blood cultures has been reported in several countries. This represents an important challenge for public health due to the large number of hospital admissions with high mortality among these patients. This study aims to characterize the epidemiology and mortality associated with positive blood cultures.Study design and methodsWe performed a nationwide cohort study, identifying all individuals with a blood culture drawn in Denmark from 2010 to 2022. We estimated the incidence of positive blood cultures and 30-day mortality per 100,000 individuals and modeled the case fatality rate (CFR) and population incidences with regression techniques.ResultsWe identified almost 4 million blood cultures drawn during the study period, increasing 64% from 220,757 in 2010 to 362,239 in 2022. During this period, the underlying population increased only 10%, whereas the population of older adults above 85 years increased 3.3 times. The positivity rate was 9.8%, and the most common pathogens were Escherichia coli (29%) and other pathogens associated with urinary tract infection, whereas Staphylococcus aureus accounted for 12%, and Enterococcus faecium for 4.1%. The 30-day CFR was 17% with a small reduction during the study period, with notable differences according to species.ConclusionWe found a substantial rise in blood culture activity and the incidence of positive cultures. This rise is driven by an increasing number of older citizens, which is expected to increase further in the coming years. Considering the high risk of mortality and increasing incidence, a national surveillance of bacteremia is warranted. |
| format | Article |
| id | doaj-art-f333cd25f3b446efac1bed4b9a75ad45 |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-f333cd25f3b446efac1bed4b9a75ad452024-12-20T06:29:15ZengFrontiers Media S.A.Frontiers in Public Health2296-25652024-12-011210.3389/fpubh.2024.15028931502893The increasing incidence and mortality of bacteremia in Denmark from 2010 to 2022: a population-based nationwide cohort studyRam B. Dessau0Ram B. Dessau1Ram B. Dessau2Christian Østergaard Andersen3Christian Østergaard Andersen4John Coia5Svend Ellermann-Eriksen6Sophie Gubbels7Thøger Gorm Jensen8Jenny Dahl Knudsen9Jonas Kähler10Steen Lomborg11Lisbeth Lützen12Marc Trunjer Kusk Nielsen13Bente Scharvik Olesen14Mette Pinholt15Flemming Scheutz16Kirstine Kobberøe Søgaard17Marianne Voldstedlund18Kåre Mølbak19Kåre Mølbak20Department of Data Integration and Analysis, Statens Serum Institut, Copenhagen, DenmarkDepartment of Clinical Microbiology, Zealand University Hospital, Slagelse, DenmarkDepartment of Regional Health Research, University of Southern Denmark, Odense, DenmarkDepartment of Diagnostic and Infectious Disease Preparedness, Statens Seruminstitut, Copenhagen, DenmarkDepartment of Clinical Microbiology, Hvidovre University Hospital, Hvidovre, DenmarkDepartment of Regional Health Research, Research Unit of Clinical Microbiology, Esbjerg, DenmarkDepartment of Clinical Microbiology, Aarhus University Hospital, Aarhus, DenmarkDepartment of Data Integration and Analysis, Statens Serum Institut, Copenhagen, DenmarkDepartment of Clinical Microbiology, Odense University Hospital, Odense, DenmarkDepartment of Clinical Microbiology, Rigshospitalet, Copenhagen, DenmarkDepartment of Data Integration and Analysis, Statens Serum Institut, Copenhagen, Denmark0Department of Clinical Microbiology, Sygehus Sønderjylland, Aabenraa, Denmark1Department of Clinical Microbiology, Sygehus Lillebælt, Vejle, DenmarkDepartment of Regional Health Research, Research Unit of Clinical Microbiology, Esbjerg, Denmark2Department of Clinical Microbiology, Herlev Hospital, Herlev, DenmarkDepartment of Clinical Microbiology, Hvidovre University Hospital, Hvidovre, Denmark3The International Escherichia and Klebsiella Centre, Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark4Department of Clinical Microbiology, Aalborg Hospital, Aalborg, DenmarkDepartment of Data Integration and Analysis, Statens Serum Institut, Copenhagen, Denmark5Department of Veterinary and Animal Science, Faculty of Health, University of Copenhagen, Copenhagen, Denmark6Epidemiological Infectious Disease Preparedness, Statens Serum Institut, Copenhagen, DenmarkObjectivesAn increasing incidence of positive blood cultures has been reported in several countries. This represents an important challenge for public health due to the large number of hospital admissions with high mortality among these patients. This study aims to characterize the epidemiology and mortality associated with positive blood cultures.Study design and methodsWe performed a nationwide cohort study, identifying all individuals with a blood culture drawn in Denmark from 2010 to 2022. We estimated the incidence of positive blood cultures and 30-day mortality per 100,000 individuals and modeled the case fatality rate (CFR) and population incidences with regression techniques.ResultsWe identified almost 4 million blood cultures drawn during the study period, increasing 64% from 220,757 in 2010 to 362,239 in 2022. During this period, the underlying population increased only 10%, whereas the population of older adults above 85 years increased 3.3 times. The positivity rate was 9.8%, and the most common pathogens were Escherichia coli (29%) and other pathogens associated with urinary tract infection, whereas Staphylococcus aureus accounted for 12%, and Enterococcus faecium for 4.1%. The 30-day CFR was 17% with a small reduction during the study period, with notable differences according to species.ConclusionWe found a substantial rise in blood culture activity and the incidence of positive cultures. This rise is driven by an increasing number of older citizens, which is expected to increase further in the coming years. Considering the high risk of mortality and increasing incidence, a national surveillance of bacteremia is warranted.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1502893/fullbacteremiaepidemiologyblood cultureaging adultsurinary tract infection |
| spellingShingle | Ram B. Dessau Ram B. Dessau Ram B. Dessau Christian Østergaard Andersen Christian Østergaard Andersen John Coia Svend Ellermann-Eriksen Sophie Gubbels Thøger Gorm Jensen Jenny Dahl Knudsen Jonas Kähler Steen Lomborg Lisbeth Lützen Marc Trunjer Kusk Nielsen Bente Scharvik Olesen Mette Pinholt Flemming Scheutz Kirstine Kobberøe Søgaard Marianne Voldstedlund Kåre Mølbak Kåre Mølbak The increasing incidence and mortality of bacteremia in Denmark from 2010 to 2022: a population-based nationwide cohort study Frontiers in Public Health bacteremia epidemiology blood culture aging adults urinary tract infection |
| title | The increasing incidence and mortality of bacteremia in Denmark from 2010 to 2022: a population-based nationwide cohort study |
| title_full | The increasing incidence and mortality of bacteremia in Denmark from 2010 to 2022: a population-based nationwide cohort study |
| title_fullStr | The increasing incidence and mortality of bacteremia in Denmark from 2010 to 2022: a population-based nationwide cohort study |
| title_full_unstemmed | The increasing incidence and mortality of bacteremia in Denmark from 2010 to 2022: a population-based nationwide cohort study |
| title_short | The increasing incidence and mortality of bacteremia in Denmark from 2010 to 2022: a population-based nationwide cohort study |
| title_sort | increasing incidence and mortality of bacteremia in denmark from 2010 to 2022 a population based nationwide cohort study |
| topic | bacteremia epidemiology blood culture aging adults urinary tract infection |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1502893/full |
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