Chiral polymer-induced hydroxyapatite for promoting bone regeneration
Chirality is one of the basic characteristics of living matter, yet the effect of chiral polymers on osteogenesis is seldom studied. Thus, it is necessary to deeply recognize the behaviors of chiral polymers in osteogenic processes, which can be beneficial for the development of bone repair material...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425000183 |
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| author | Zongying Zhang Bing Liang Dan Wang Ying Zhang Zhongmin Geng Dongming Xing |
| author_facet | Zongying Zhang Bing Liang Dan Wang Ying Zhang Zhongmin Geng Dongming Xing |
| author_sort | Zongying Zhang |
| collection | DOAJ |
| description | Chirality is one of the basic characteristics of living matter, yet the effect of chiral polymers on osteogenesis is seldom studied. Thus, it is necessary to deeply recognize the behaviors of chiral polymers in osteogenic processes, which can be beneficial for the development of bone repair materials. In this work, chiral hydroxyapatite (HAP) was constructed simply using poly(levorotatory/dextral-tartaric acid) as the guest of the chiral transfer system. We studied the influence of chiral HAPs on the migration and differentiation of pre-osteoblasts, and angiogenesis of endothelial cell in vitro. The results showed that poly(levorotatory-tartaric acid)-induced HAP did promote vascular remodeling and exhibited excellent impact on osteogenetic differentiation by improving the related gene and protein expression, whereas no significant change was observed in poly(dextral-tartaric acid) or poly(racemic-tartaric acid) induced HAP, respectively. This study highlighted the effects of chiral polymers on osteogenic potential, which laid the groundwork for the development of biomaterials for bone regeneration. |
| format | Article |
| id | doaj-art-f33214ac9db34e4faa97e2c1383ba199 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-f33214ac9db34e4faa97e2c1383ba1992025-01-14T04:12:34ZengElsevierMaterials Today Bio2590-00642025-04-0131101460Chiral polymer-induced hydroxyapatite for promoting bone regenerationZongying Zhang0Bing Liang1Dan Wang2Ying Zhang3Zhongmin Geng4Dongming Xing5Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China; School of Basic Medicine Qingdao University, Qingdao University, Qingdao, 266071, ChinaCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, ChinaCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China; School of Basic Medicine Qingdao University, Qingdao University, Qingdao, 266071, ChinaCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, ChinaCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China; Corresponding author.Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China; School of Life Sciences, Tsinghua University, Beijing, 100084, China; Corresponding author. Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China.Chirality is one of the basic characteristics of living matter, yet the effect of chiral polymers on osteogenesis is seldom studied. Thus, it is necessary to deeply recognize the behaviors of chiral polymers in osteogenic processes, which can be beneficial for the development of bone repair materials. In this work, chiral hydroxyapatite (HAP) was constructed simply using poly(levorotatory/dextral-tartaric acid) as the guest of the chiral transfer system. We studied the influence of chiral HAPs on the migration and differentiation of pre-osteoblasts, and angiogenesis of endothelial cell in vitro. The results showed that poly(levorotatory-tartaric acid)-induced HAP did promote vascular remodeling and exhibited excellent impact on osteogenetic differentiation by improving the related gene and protein expression, whereas no significant change was observed in poly(dextral-tartaric acid) or poly(racemic-tartaric acid) induced HAP, respectively. This study highlighted the effects of chiral polymers on osteogenic potential, which laid the groundwork for the development of biomaterials for bone regeneration.http://www.sciencedirect.com/science/article/pii/S2590006425000183ChiralPoly(levorotatory-hydroxyapatite)Vascular remodelingBone regeneration |
| spellingShingle | Zongying Zhang Bing Liang Dan Wang Ying Zhang Zhongmin Geng Dongming Xing Chiral polymer-induced hydroxyapatite for promoting bone regeneration Materials Today Bio Chiral Poly(levorotatory-hydroxyapatite) Vascular remodeling Bone regeneration |
| title | Chiral polymer-induced hydroxyapatite for promoting bone regeneration |
| title_full | Chiral polymer-induced hydroxyapatite for promoting bone regeneration |
| title_fullStr | Chiral polymer-induced hydroxyapatite for promoting bone regeneration |
| title_full_unstemmed | Chiral polymer-induced hydroxyapatite for promoting bone regeneration |
| title_short | Chiral polymer-induced hydroxyapatite for promoting bone regeneration |
| title_sort | chiral polymer induced hydroxyapatite for promoting bone regeneration |
| topic | Chiral Poly(levorotatory-hydroxyapatite) Vascular remodeling Bone regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425000183 |
| work_keys_str_mv | AT zongyingzhang chiralpolymerinducedhydroxyapatiteforpromotingboneregeneration AT bingliang chiralpolymerinducedhydroxyapatiteforpromotingboneregeneration AT danwang chiralpolymerinducedhydroxyapatiteforpromotingboneregeneration AT yingzhang chiralpolymerinducedhydroxyapatiteforpromotingboneregeneration AT zhongmingeng chiralpolymerinducedhydroxyapatiteforpromotingboneregeneration AT dongmingxing chiralpolymerinducedhydroxyapatiteforpromotingboneregeneration |