Neutrophil-mediated degradation of type III collagen is elevated in inflammatory bowel disease and DSS-induced colitis reflecting early mucosal damage

Neutrophil-mediated degradation of type III collagen is elevated in inflammatory bowel disease and DSS-induced colitis reflecting early mucosal damage

Abstract Inflammatory Bowel Disease (IBD) is characterized by mucosal injury in the gastrointestinal (GI) tract. During an abnormal immune response in the GI tract, excessive secretion of immune-cell proteases occurs. Neutrophils are the first responders, infiltrating into the inflamed interstitial...

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Bibliographic Details
Main Authors: Thomai Tsapanou-Katranara, Marta S. Alexdottir, Majken Lindholm Olesen, Viktor Domislović, Anne-Christine Bay-Jensen, Morten Asser Karsdal, Željko Krznarić, Jens Kjeldsen, Mark A. Ainsworth, Joachim H. Mortensen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Inflammatory bowel disease
Neutrophil elastase
Type III collagen
Biomarker
Subclinical Inflammation
Intestinal mucosal damage
Online Access:https://doi.org/10.1038/s41598-025-09043-6
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