Advances in research on SATB2 and its role in tumor development
Abstract SATB2 is an AT-rich DNA-binding protein with a highly restricted expression pattern, primarily found in the brain, digestive tract, bone, and immune system, making it a promising target for medical research and clinical applications. Dysregulation or mutations in SATB2 have been implicated...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | Cell & Bioscience |
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| Online Access: | https://doi.org/10.1186/s13578-025-01439-1 |
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| author | Ge Cheng Chi Tian Waner Wang Yangyang Zhou Xiaoqing Wang Lei Zhang |
| author_facet | Ge Cheng Chi Tian Waner Wang Yangyang Zhou Xiaoqing Wang Lei Zhang |
| author_sort | Ge Cheng |
| collection | DOAJ |
| description | Abstract SATB2 is an AT-rich DNA-binding protein with a highly restricted expression pattern, primarily found in the brain, digestive tract, bone, and immune system, making it a promising target for medical research and clinical applications. Dysregulation or mutations in SATB2 have been implicated in various conditions, including cancers, isolated cleft palate, and SATB2-associated syndrome (SAS). This review aims to provide a comprehensive summary of the structure, biological functions, and potential role of SATB2 in tumor development. SATB2 influences gene regulation through epigenetic modulation, impacting various biological activities, including cell differentiation and immune responses. Recent studies have increasingly recognized its roles in tumorigenesis, including its contributions to cancer progression and metastasis. Moreover, SATB2 shows promise as a diagnostic marker and therapeutic target in oncology and bone-related disorders. Understanding its precise mechanisms in these contexts can pave the way for future advancements in therapeutic strategies. This review highlights the current state of knowledge on the roles of SATB2 and discusses its structural characteristics, biological functions, and potential implications in tumor development. |
| format | Article |
| id | doaj-art-f321a44142ec49efb3d95d8d7f9c2f86 |
| institution | Kabale University |
| issn | 2045-3701 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj-art-f321a44142ec49efb3d95d8d7f9c2f862025-08-20T04:02:50ZengBMCCell & Bioscience2045-37012025-07-0115111210.1186/s13578-025-01439-1Advances in research on SATB2 and its role in tumor developmentGe Cheng0Chi Tian1Waner Wang2Yangyang Zhou3Xiaoqing Wang4Lei Zhang5Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Henan UniversityDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Henan UniversityDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Henan UniversityDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Henan UniversityDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Henan UniversityShanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of MedicineAbstract SATB2 is an AT-rich DNA-binding protein with a highly restricted expression pattern, primarily found in the brain, digestive tract, bone, and immune system, making it a promising target for medical research and clinical applications. Dysregulation or mutations in SATB2 have been implicated in various conditions, including cancers, isolated cleft palate, and SATB2-associated syndrome (SAS). This review aims to provide a comprehensive summary of the structure, biological functions, and potential role of SATB2 in tumor development. SATB2 influences gene regulation through epigenetic modulation, impacting various biological activities, including cell differentiation and immune responses. Recent studies have increasingly recognized its roles in tumorigenesis, including its contributions to cancer progression and metastasis. Moreover, SATB2 shows promise as a diagnostic marker and therapeutic target in oncology and bone-related disorders. Understanding its precise mechanisms in these contexts can pave the way for future advancements in therapeutic strategies. This review highlights the current state of knowledge on the roles of SATB2 and discusses its structural characteristics, biological functions, and potential implications in tumor development.https://doi.org/10.1186/s13578-025-01439-1SATB2Tumor developmentGene regulationEpigenetic modulation |
| spellingShingle | Ge Cheng Chi Tian Waner Wang Yangyang Zhou Xiaoqing Wang Lei Zhang Advances in research on SATB2 and its role in tumor development Cell & Bioscience SATB2 Tumor development Gene regulation Epigenetic modulation |
| title | Advances in research on SATB2 and its role in tumor development |
| title_full | Advances in research on SATB2 and its role in tumor development |
| title_fullStr | Advances in research on SATB2 and its role in tumor development |
| title_full_unstemmed | Advances in research on SATB2 and its role in tumor development |
| title_short | Advances in research on SATB2 and its role in tumor development |
| title_sort | advances in research on satb2 and its role in tumor development |
| topic | SATB2 Tumor development Gene regulation Epigenetic modulation |
| url | https://doi.org/10.1186/s13578-025-01439-1 |
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