The role of transcription factors in the crosstalk between cancer-associated fibroblasts and tumor cells
Background: Transcription factors (TFs) fulfill a critical role in the formation and maintenance of different cell types during the developmental process as well as disease. It is believed that cancer-associated fibroblasts (CAFs) are activation status of tissue-resident fibroblasts or derived from...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Advanced Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123224000468 |
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| author | Xiaoyan Zhang Meng Zhang Hui Sun Xu Wang Xin Wang Weiqi Sheng Midie Xu |
| author_facet | Xiaoyan Zhang Meng Zhang Hui Sun Xu Wang Xin Wang Weiqi Sheng Midie Xu |
| author_sort | Xiaoyan Zhang |
| collection | DOAJ |
| description | Background: Transcription factors (TFs) fulfill a critical role in the formation and maintenance of different cell types during the developmental process as well as disease. It is believed that cancer-associated fibroblasts (CAFs) are activation status of tissue-resident fibroblasts or derived from form other cell types via transdifferentiation or dedifferentiation. Despite a subgroup of CAFs exhibit anti-cancer effects, most of them are reported to exert effects on tumor progression, further indicating their heterogeneous origin. Aim of review: This review aimed to summarize and review the roles of TFs in the reciprocal crosstalk between CAFs and tumor cells, discuss the emerging mechanisms, and their roles in cell-fate decision, cellular reprogramming and advancing our understanding of the gene regulatory networks over the period of cancer initiation and progression. Key scientific concepts of review: This manuscript delves into the key contributory factors of TFs that are involved in activating CAFs and maintaining their unique states. Additionally, it explores how TFs play a pivotal and multifaceted role in the reciprocal crosstalk between CAFs and tumor cells. This includes their involvement in processes such as epithelial-mesenchymal transition (EMT), proliferation, invasion, and metastasis, as well as metabolic reprogramming. TFs also have a role in constructing an immunosuppressive microenvironment, inducing resistance to radiation and chemotherapy, facilitating angiogenesis, and even 'educating' CAFs to support the malignancies of tumor cells. Furthermore, this manuscript delves into the current status of TF-targeted therapy and considers the future directions of TFs in conjunction with anti-CAFs therapies to address the challenges in clinical cancer treatment. |
| format | Article |
| id | doaj-art-f30d75cf8ad448c08ff0284feca80cd2 |
| institution | OA Journals |
| issn | 2090-1232 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj-art-f30d75cf8ad448c08ff0284feca80cd22025-08-20T02:37:06ZengElsevierJournal of Advanced Research2090-12322025-01-016712113210.1016/j.jare.2024.01.033The role of transcription factors in the crosstalk between cancer-associated fibroblasts and tumor cellsXiaoyan Zhang0Meng Zhang1Hui Sun2Xu Wang3Xin Wang4Weiqi Sheng5Midie Xu6Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, ChinaDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, ChinaDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, ChinaDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, ChinaDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, ChinaDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, China; Corresponding authors at: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, China; Corresponding authors at: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.Background: Transcription factors (TFs) fulfill a critical role in the formation and maintenance of different cell types during the developmental process as well as disease. It is believed that cancer-associated fibroblasts (CAFs) are activation status of tissue-resident fibroblasts or derived from form other cell types via transdifferentiation or dedifferentiation. Despite a subgroup of CAFs exhibit anti-cancer effects, most of them are reported to exert effects on tumor progression, further indicating their heterogeneous origin. Aim of review: This review aimed to summarize and review the roles of TFs in the reciprocal crosstalk between CAFs and tumor cells, discuss the emerging mechanisms, and their roles in cell-fate decision, cellular reprogramming and advancing our understanding of the gene regulatory networks over the period of cancer initiation and progression. Key scientific concepts of review: This manuscript delves into the key contributory factors of TFs that are involved in activating CAFs and maintaining their unique states. Additionally, it explores how TFs play a pivotal and multifaceted role in the reciprocal crosstalk between CAFs and tumor cells. This includes their involvement in processes such as epithelial-mesenchymal transition (EMT), proliferation, invasion, and metastasis, as well as metabolic reprogramming. TFs also have a role in constructing an immunosuppressive microenvironment, inducing resistance to radiation and chemotherapy, facilitating angiogenesis, and even 'educating' CAFs to support the malignancies of tumor cells. Furthermore, this manuscript delves into the current status of TF-targeted therapy and considers the future directions of TFs in conjunction with anti-CAFs therapies to address the challenges in clinical cancer treatment.http://www.sciencedirect.com/science/article/pii/S2090123224000468Cancer-associated fibroblastsTranscription factorsCrosstalkMalignant behaviors |
| spellingShingle | Xiaoyan Zhang Meng Zhang Hui Sun Xu Wang Xin Wang Weiqi Sheng Midie Xu The role of transcription factors in the crosstalk between cancer-associated fibroblasts and tumor cells Journal of Advanced Research Cancer-associated fibroblasts Transcription factors Crosstalk Malignant behaviors |
| title | The role of transcription factors in the crosstalk between cancer-associated fibroblasts and tumor cells |
| title_full | The role of transcription factors in the crosstalk between cancer-associated fibroblasts and tumor cells |
| title_fullStr | The role of transcription factors in the crosstalk between cancer-associated fibroblasts and tumor cells |
| title_full_unstemmed | The role of transcription factors in the crosstalk between cancer-associated fibroblasts and tumor cells |
| title_short | The role of transcription factors in the crosstalk between cancer-associated fibroblasts and tumor cells |
| title_sort | role of transcription factors in the crosstalk between cancer associated fibroblasts and tumor cells |
| topic | Cancer-associated fibroblasts Transcription factors Crosstalk Malignant behaviors |
| url | http://www.sciencedirect.com/science/article/pii/S2090123224000468 |
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