Navigating chronic pancreatitis pain: a pathophysiological and therapeutic overview
Pain management in chronic pancreatitis (CP) patients remains a major challenge, largely due to complex and refractory pain. Such pain detrimentally impacts patients by reducing quality of life, limiting daily activities, increasing psychological distress, necessitating frequent hospitalizations, an...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2025.1622845/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849428151263821824 |
|---|---|
| author | Zijin Lin Stephen Pandol Minoti Apte Yi Jiang |
| author_facet | Zijin Lin Stephen Pandol Minoti Apte Yi Jiang |
| author_sort | Zijin Lin |
| collection | DOAJ |
| description | Pain management in chronic pancreatitis (CP) patients remains a major challenge, largely due to complex and refractory pain. Such pain detrimentally impacts patients by reducing quality of life, limiting daily activities, increasing psychological distress, necessitating frequent hospitalizations, and contributing to opioid dependence and socioeconomic burden. This review delineates the multifaceted nature of CP-related pain, highlighting the roles of neurogenic inflammation, maladaptive neuroplasticity, and disrupted pain modulation pathways. Current management strategies are multidisciplinary, encompassing lifestyle modification, pharmacologic therapies, endoscopic and surgical interventions, and nerve-targeted procedures (e.g., celiac plexus blocks and neurolysis). Advances in genetics, bioinformatics and biomarker research have further enhanced our understanding of CP-related pain pathogenesis, paving the way for precision medicine approaches. This review highlights current evidence and emerging innovations in the evolving landscape of CP-related pain management, emphasizing the importance of tailored and interdisciplinary care to address the intricate mechanism of CP-related pain and improve patient outcomes. |
| format | Article |
| id | doaj-art-f30a7d2c4cda4ca48688bd90f2e6166e |
| institution | Kabale University |
| issn | 1664-042X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj-art-f30a7d2c4cda4ca48688bd90f2e6166e2025-08-20T03:28:47ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2025-07-011610.3389/fphys.2025.16228451622845Navigating chronic pancreatitis pain: a pathophysiological and therapeutic overviewZijin Lin0Stephen Pandol1Minoti Apte2Yi Jiang3College of osteopathic medicine, Michigan State University, East Lansing, MI, United StatesKarsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesPancreatic Research Group, South Western Sydney Clinical Campuses, Faculty of Medicine and Health, The University of New South Wales, Ingham Institute for Applied Medical Research, Sydney, NSW, AustraliaKarsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesPain management in chronic pancreatitis (CP) patients remains a major challenge, largely due to complex and refractory pain. Such pain detrimentally impacts patients by reducing quality of life, limiting daily activities, increasing psychological distress, necessitating frequent hospitalizations, and contributing to opioid dependence and socioeconomic burden. This review delineates the multifaceted nature of CP-related pain, highlighting the roles of neurogenic inflammation, maladaptive neuroplasticity, and disrupted pain modulation pathways. Current management strategies are multidisciplinary, encompassing lifestyle modification, pharmacologic therapies, endoscopic and surgical interventions, and nerve-targeted procedures (e.g., celiac plexus blocks and neurolysis). Advances in genetics, bioinformatics and biomarker research have further enhanced our understanding of CP-related pain pathogenesis, paving the way for precision medicine approaches. This review highlights current evidence and emerging innovations in the evolving landscape of CP-related pain management, emphasizing the importance of tailored and interdisciplinary care to address the intricate mechanism of CP-related pain and improve patient outcomes.https://www.frontiersin.org/articles/10.3389/fphys.2025.1622845/fullcentral sensitisationchronic pancreatitisquality of lifepain managemantneurogenic inflammation |
| spellingShingle | Zijin Lin Stephen Pandol Minoti Apte Yi Jiang Navigating chronic pancreatitis pain: a pathophysiological and therapeutic overview Frontiers in Physiology central sensitisation chronic pancreatitis quality of life pain managemant neurogenic inflammation |
| title | Navigating chronic pancreatitis pain: a pathophysiological and therapeutic overview |
| title_full | Navigating chronic pancreatitis pain: a pathophysiological and therapeutic overview |
| title_fullStr | Navigating chronic pancreatitis pain: a pathophysiological and therapeutic overview |
| title_full_unstemmed | Navigating chronic pancreatitis pain: a pathophysiological and therapeutic overview |
| title_short | Navigating chronic pancreatitis pain: a pathophysiological and therapeutic overview |
| title_sort | navigating chronic pancreatitis pain a pathophysiological and therapeutic overview |
| topic | central sensitisation chronic pancreatitis quality of life pain managemant neurogenic inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2025.1622845/full |
| work_keys_str_mv | AT zijinlin navigatingchronicpancreatitispainapathophysiologicalandtherapeuticoverview AT stephenpandol navigatingchronicpancreatitispainapathophysiologicalandtherapeuticoverview AT minotiapte navigatingchronicpancreatitispainapathophysiologicalandtherapeuticoverview AT yijiang navigatingchronicpancreatitispainapathophysiologicalandtherapeuticoverview |