Immunotoxicity assessment of multiwalled carbon nanotubes following whole-body inhalation exposure for 30 and 90 days in B6C3F1/N mice and 30 days in HSD:Harlan Sprague Dawley SD® rats

Immunotoxicity assessment of multiwalled carbon nanotubes following whole-body inhalation exposure for 30 and 90 days in B6C3F1/N mice and 30 days in HSD:Harlan Sprague Dawley SD® rats

BackgroundSeveral lines of evidence suggest the possibility that inhalation exposure to multi-walled carbon nanotubes (MWCNT) at occupationally relevant doses can lead to systemic immunotoxicity. To test this hypothesis, we undertook in-depth examination of immune function in mice and rats exposed b...

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Bibliographic Details
Main Authors: Victor J. Johnson, Nigel J. Walker, Michael I. Luster, Gary R. Burleson, Michelle Cora, Gregory L. Baker, Barney Sparrow, Dori R. Germolec
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Toxicology
Subjects:
multiwalled carbon nanotubes
MWCNT
immunotoxicity testing
innate immunity
humoral immunity
1020 long multiwalled carbon nanotubes
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2025.1539810/full
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