Does Extending the Waiting Time of Low-Rectal Cancer Surgery after Neoadjuvant Chemoradiation Increase the Perioperative Complications?
Background. Traditionally, rectal cancer surgery is recommended 6 to 8 weeks after completing neoadjuvant chemoradiation. Extending the waiting time may increase the tumor response rate. However, the perioperative complication rate may increase. The purpose of this study was to determine the associa...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/7870815 |
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| author | Kittinut Timudom Natthawut Phothong Thawatchai Akaraviputh Vitoon Chinswangwatanakul Ananya Pongpaibul Janjira Petsuksiri Suthinee Ithimakin Atthaphorn Trakarnsanga |
| author_facet | Kittinut Timudom Natthawut Phothong Thawatchai Akaraviputh Vitoon Chinswangwatanakul Ananya Pongpaibul Janjira Petsuksiri Suthinee Ithimakin Atthaphorn Trakarnsanga |
| author_sort | Kittinut Timudom |
| collection | DOAJ |
| description | Background. Traditionally, rectal cancer surgery is recommended 6 to 8 weeks after completing neoadjuvant chemoradiation. Extending the waiting time may increase the tumor response rate. However, the perioperative complication rate may increase. The purpose of this study was to determine the association between extending the waiting time of surgery after neoadjuvant chemoradiation and perioperative outcomes. Methods. Sixty patients with locally advanced rectal cancer who underwent neoadjuvant chemoradiation followed by radical resection at Siriraj hospital between June 2012 and January 2015 were retrospectively analyzed. Demographic data and perioperative outcomes were compared between the two groups. Results. The two groups were comparable in term of demographic parameters. The mean time interval from neoadjuvant chemoradiation to surgery was 6.4 weeks in Group A and 11.7 weeks in Group B. The perioperative outcomes were not significantly different between Groups A and B. Pathologic examination showed a significantly higher rate of circumferential margin positivity in Group A than in Group B (30% versus 9.3%, resp.; P=0.04). Conclusions. Extending the waiting to >8 weeks from neoadjuvant chemoradiation to surgery did not increase perioperative complications, whereas the rate of circumferential margin positivity decreased. |
| format | Article |
| id | doaj-art-f2ea2e8bf3104a4ea47dd33f29817957 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-f2ea2e8bf3104a4ea47dd33f298179572025-02-03T07:24:03ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/78708157870815Does Extending the Waiting Time of Low-Rectal Cancer Surgery after Neoadjuvant Chemoradiation Increase the Perioperative Complications?Kittinut Timudom0Natthawut Phothong1Thawatchai Akaraviputh2Vitoon Chinswangwatanakul3Ananya Pongpaibul4Janjira Petsuksiri5Suthinee Ithimakin6Atthaphorn Trakarnsanga7Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Surgery, Panyananthaphikkhu Chonprathan Medical Center, Srinakharinwirot University, Nonthaburi, ThailandDepartment of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Radiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, ThailandDivision of Medical Oncology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, ThailandBackground. Traditionally, rectal cancer surgery is recommended 6 to 8 weeks after completing neoadjuvant chemoradiation. Extending the waiting time may increase the tumor response rate. However, the perioperative complication rate may increase. The purpose of this study was to determine the association between extending the waiting time of surgery after neoadjuvant chemoradiation and perioperative outcomes. Methods. Sixty patients with locally advanced rectal cancer who underwent neoadjuvant chemoradiation followed by radical resection at Siriraj hospital between June 2012 and January 2015 were retrospectively analyzed. Demographic data and perioperative outcomes were compared between the two groups. Results. The two groups were comparable in term of demographic parameters. The mean time interval from neoadjuvant chemoradiation to surgery was 6.4 weeks in Group A and 11.7 weeks in Group B. The perioperative outcomes were not significantly different between Groups A and B. Pathologic examination showed a significantly higher rate of circumferential margin positivity in Group A than in Group B (30% versus 9.3%, resp.; P=0.04). Conclusions. Extending the waiting to >8 weeks from neoadjuvant chemoradiation to surgery did not increase perioperative complications, whereas the rate of circumferential margin positivity decreased.http://dx.doi.org/10.1155/2016/7870815 |
| spellingShingle | Kittinut Timudom Natthawut Phothong Thawatchai Akaraviputh Vitoon Chinswangwatanakul Ananya Pongpaibul Janjira Petsuksiri Suthinee Ithimakin Atthaphorn Trakarnsanga Does Extending the Waiting Time of Low-Rectal Cancer Surgery after Neoadjuvant Chemoradiation Increase the Perioperative Complications? Gastroenterology Research and Practice |
| title | Does Extending the Waiting Time of Low-Rectal Cancer Surgery after Neoadjuvant Chemoradiation Increase the Perioperative Complications? |
| title_full | Does Extending the Waiting Time of Low-Rectal Cancer Surgery after Neoadjuvant Chemoradiation Increase the Perioperative Complications? |
| title_fullStr | Does Extending the Waiting Time of Low-Rectal Cancer Surgery after Neoadjuvant Chemoradiation Increase the Perioperative Complications? |
| title_full_unstemmed | Does Extending the Waiting Time of Low-Rectal Cancer Surgery after Neoadjuvant Chemoradiation Increase the Perioperative Complications? |
| title_short | Does Extending the Waiting Time of Low-Rectal Cancer Surgery after Neoadjuvant Chemoradiation Increase the Perioperative Complications? |
| title_sort | does extending the waiting time of low rectal cancer surgery after neoadjuvant chemoradiation increase the perioperative complications |
| url | http://dx.doi.org/10.1155/2016/7870815 |
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