Role of the USP7/FOXO3A axis in environmentally relevant doses of arsenic-induced lung carcinogenesis: Insights from bioinformatics analysis and model of human epithelial cell malignant transformation

Role of the USP7/FOXO3A axis in environmentally relevant doses of arsenic-induced lung carcinogenesis: Insights from bioinformatics analysis and model of human epithelial cell malignant transformation

Arsenic (As) is classified as a Group 1 carcinogen by the International Agency for Research on Cancer (IARC). Exposure to As has been associated with an increased risk of various cancers, particularly lung cancer. However, the precise molecular mechanisms contributing to this carcinogenesis are not...

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Bibliographic Details
Main Authors: Xiaoyu Chen, Yuqing Wang, Ziqi Liu, Yujie He, Huan Gao, Xinchao Guan, Liping Chen, Shen Chen, Xiumei Xing, Wen Chen, Daochuan Li, Qing Wang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Ecotoxicology and Environmental Safety
Subjects:
As
Lung cancer
Bioinformatics
Malignant transformation
USP7
FOXO3A
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325005603
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