Mesenchymal Stromal Cells and Viral Infection
Mesenchymal Stromal Cells (MSCs) are a subset of nonhematopoietic adult stem cells, readily isolated from various tissues and easily culture-expanded ex vivo. Intensive studies of the immune modulation and tissue regeneration over the past few years have demonstrated the great potential of MSCs for...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/860950 |
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| author | Maytawan Thanunchai Suradej Hongeng Arunee Thitithanyanont |
| author_facet | Maytawan Thanunchai Suradej Hongeng Arunee Thitithanyanont |
| author_sort | Maytawan Thanunchai |
| collection | DOAJ |
| description | Mesenchymal Stromal Cells (MSCs) are a subset of nonhematopoietic adult stem cells, readily isolated from various tissues and easily culture-expanded ex vivo. Intensive studies of the immune modulation and tissue regeneration over the past few years have demonstrated the great potential of MSCs for the prevention and treatment of steroid-resistant acute graft-versus-host disease (GvHD), immune-related disorders, and viral diseases. In immunocompromised individuals, the immunomodulatory activities of MSCs have raised safety concerns regarding the greater risk of primary viral infection and viral reactivation, which is a major cause of mortality after allogeneic transplantation. Moreover, high susceptibilities of MSCs to viral infections in vitro could reflect the destructive outcomes that might impair the clinical efficacy of MSCs infusion. However, the interplay between MSCs and virus is like a double-edge sword, and it also provides beneficial effects such as allowing the proliferation and function of antiviral specific effector cells instead of suppressing them, serving as an ideal tool for study of viral pathogenesis, and protecting hosts against viral challenge by using the antimicrobial activity. Here, we therefore review favorable and unfavorable consequences of MSCs and virus interaction with the highlight of safety and efficacy for applying MSCs as cell therapy. |
| format | Article |
| id | doaj-art-f2d9d82295054cfdad146d7b3e7991c9 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-f2d9d82295054cfdad146d7b3e7991c92025-02-03T01:20:37ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/860950860950Mesenchymal Stromal Cells and Viral InfectionMaytawan Thanunchai0Suradej Hongeng1Arunee Thitithanyanont2Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandDepartment of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandDepartment of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, ThailandMesenchymal Stromal Cells (MSCs) are a subset of nonhematopoietic adult stem cells, readily isolated from various tissues and easily culture-expanded ex vivo. Intensive studies of the immune modulation and tissue regeneration over the past few years have demonstrated the great potential of MSCs for the prevention and treatment of steroid-resistant acute graft-versus-host disease (GvHD), immune-related disorders, and viral diseases. In immunocompromised individuals, the immunomodulatory activities of MSCs have raised safety concerns regarding the greater risk of primary viral infection and viral reactivation, which is a major cause of mortality after allogeneic transplantation. Moreover, high susceptibilities of MSCs to viral infections in vitro could reflect the destructive outcomes that might impair the clinical efficacy of MSCs infusion. However, the interplay between MSCs and virus is like a double-edge sword, and it also provides beneficial effects such as allowing the proliferation and function of antiviral specific effector cells instead of suppressing them, serving as an ideal tool for study of viral pathogenesis, and protecting hosts against viral challenge by using the antimicrobial activity. Here, we therefore review favorable and unfavorable consequences of MSCs and virus interaction with the highlight of safety and efficacy for applying MSCs as cell therapy.http://dx.doi.org/10.1155/2015/860950 |
| spellingShingle | Maytawan Thanunchai Suradej Hongeng Arunee Thitithanyanont Mesenchymal Stromal Cells and Viral Infection Stem Cells International |
| title | Mesenchymal Stromal Cells and Viral Infection |
| title_full | Mesenchymal Stromal Cells and Viral Infection |
| title_fullStr | Mesenchymal Stromal Cells and Viral Infection |
| title_full_unstemmed | Mesenchymal Stromal Cells and Viral Infection |
| title_short | Mesenchymal Stromal Cells and Viral Infection |
| title_sort | mesenchymal stromal cells and viral infection |
| url | http://dx.doi.org/10.1155/2015/860950 |
| work_keys_str_mv | AT maytawanthanunchai mesenchymalstromalcellsandviralinfection AT suradejhongeng mesenchymalstromalcellsandviralinfection AT aruneethitithanyanont mesenchymalstromalcellsandviralinfection |