Tryptophan pathway profiling in multiple sclerosis patients treated with ocrelizumab

Tryptophan pathway profiling in multiple sclerosis patients treated with ocrelizumab

IntroductionL-Tryptophan (Trp) metabolism is impaired across various chronic inflammatory pathologies, including Multiple Sclerosis (MS). Trp processing relies on three metabolic routes, namely Kynurenine, Serotonin and Indole pathways. The host microbiota significantly impacts Trp metabolism, prima...

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Bibliographic Details
Main Authors: Carolina Ricci, Matteo Pivetta, Eleonora Martinis, Viviana Valeri, Carolina Colliva, Nicola Giacchè, Simone Lorenzut, Daniela Cargnelutti, Barbara Frossi, Silvia Tonon
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
ocrelizumab
tryptophan
kynurenine
serotonin
indole
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1603663/full
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