Advances in cardiac organoid research: implications for cardiovascular disease treatment
Abstract Globally, cardiovascular diseases remain among the leading causes of mortality, highlighting the urgent need for innovative research models. Consequently, the development of accurate models that simulate cardiac function holds significant scientific and clinical value for both disease resea...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Cardiovascular Diabetology |
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| Online Access: | https://doi.org/10.1186/s12933-025-02598-8 |
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| author | Ziteng Huang Keran Jia Yadan Tan Yang Yu Wudian Xiao Xiangyu Zhou Jingyan Yi Chunxiang Zhang |
| author_facet | Ziteng Huang Keran Jia Yadan Tan Yang Yu Wudian Xiao Xiangyu Zhou Jingyan Yi Chunxiang Zhang |
| author_sort | Ziteng Huang |
| collection | DOAJ |
| description | Abstract Globally, cardiovascular diseases remain among the leading causes of mortality, highlighting the urgent need for innovative research models. Consequently, the development of accurate models that simulate cardiac function holds significant scientific and clinical value for both disease research and therapeutic interventions. Cardiac organoids, which are three-dimensional structures derived from the induced differentiation of stem cells, are particularly promising. These organoids not only replicate the autonomous beating and essential electrophysiological properties of the heart but are also widely employed in studies related to cardiac diseases, drug efficacy testing, and regenerative medicine. This review comprehensively surveys the various fabrication techniques used to create cardiac organoids and their diverse applications in modeling a range of cardiac diseases. We emphasize the role of advanced technologies in enhancing the maturation and functionality of cardiac cells, ensuring that these models closely resemble native cardiac tissue. Furthermore, we discuss monitoring techniques and evaluation parameters critical for assessing the performance of cardiac organoids, considering the complex interactions within multi-organ systems. This approach is vital for enhancing precision and efficiency in drug development, allowing for more effective therapeutic strategies. Ultimately, this review aims to provide a thorough and innovative perspective on both fundamental research and clinical treatment of cardiovascular diseases, offering insights that could pave the way for future advancements in understanding and addressing these prevalent health challenges. Graphical abstract |
| format | Article |
| id | doaj-art-f2cabcea59814a89afcba71450d38567 |
| institution | Kabale University |
| issn | 1475-2840 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj-art-f2cabcea59814a89afcba71450d385672025-01-19T12:09:06ZengBMCCardiovascular Diabetology1475-28402025-01-0124111610.1186/s12933-025-02598-8Advances in cardiac organoid research: implications for cardiovascular disease treatmentZiteng Huang0Keran Jia1Yadan Tan2Yang Yu3Wudian Xiao4Xiangyu Zhou5Jingyan Yi6Chunxiang Zhang7Department of Anesthesiology, The Affiliated Hospital, Southwest Medical UniversityDepartment of Medical Cell Biology and Genetics, School of Basic Medical Sciences, Southwest Medical UniversityDepartment of Medical Cell Biology and Genetics, School of Basic Medical Sciences, Southwest Medical UniversityDepartment of Cardiology, Southwest Medical UniversityBasic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education, Southwest Medical UniversityDepartment of Thyroid Surgery, The Affiliated Hospital, Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education, Southwest Medical UniversityDepartment of Medical Cell Biology and Genetics, School of Basic Medical Sciences, Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education, Southwest Medical UniversityDepartment of Cardiology, The Affiliated Hospital, Key Laboratory of Medical Electrophysiology, Ministry of Education, Institute of Cardiovascular Research, Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education, Southwest Medical UniversityAbstract Globally, cardiovascular diseases remain among the leading causes of mortality, highlighting the urgent need for innovative research models. Consequently, the development of accurate models that simulate cardiac function holds significant scientific and clinical value for both disease research and therapeutic interventions. Cardiac organoids, which are three-dimensional structures derived from the induced differentiation of stem cells, are particularly promising. These organoids not only replicate the autonomous beating and essential electrophysiological properties of the heart but are also widely employed in studies related to cardiac diseases, drug efficacy testing, and regenerative medicine. This review comprehensively surveys the various fabrication techniques used to create cardiac organoids and their diverse applications in modeling a range of cardiac diseases. We emphasize the role of advanced technologies in enhancing the maturation and functionality of cardiac cells, ensuring that these models closely resemble native cardiac tissue. Furthermore, we discuss monitoring techniques and evaluation parameters critical for assessing the performance of cardiac organoids, considering the complex interactions within multi-organ systems. This approach is vital for enhancing precision and efficiency in drug development, allowing for more effective therapeutic strategies. Ultimately, this review aims to provide a thorough and innovative perspective on both fundamental research and clinical treatment of cardiovascular diseases, offering insights that could pave the way for future advancements in understanding and addressing these prevalent health challenges. Graphical abstracthttps://doi.org/10.1186/s12933-025-02598-8Cardiac organoidsCardiac diseasesMonitoring techniquesMulti-organ systems |
| spellingShingle | Ziteng Huang Keran Jia Yadan Tan Yang Yu Wudian Xiao Xiangyu Zhou Jingyan Yi Chunxiang Zhang Advances in cardiac organoid research: implications for cardiovascular disease treatment Cardiovascular Diabetology Cardiac organoids Cardiac diseases Monitoring techniques Multi-organ systems |
| title | Advances in cardiac organoid research: implications for cardiovascular disease treatment |
| title_full | Advances in cardiac organoid research: implications for cardiovascular disease treatment |
| title_fullStr | Advances in cardiac organoid research: implications for cardiovascular disease treatment |
| title_full_unstemmed | Advances in cardiac organoid research: implications for cardiovascular disease treatment |
| title_short | Advances in cardiac organoid research: implications for cardiovascular disease treatment |
| title_sort | advances in cardiac organoid research implications for cardiovascular disease treatment |
| topic | Cardiac organoids Cardiac diseases Monitoring techniques Multi-organ systems |
| url | https://doi.org/10.1186/s12933-025-02598-8 |
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