Management of Vasoproliferative Tumors of the Retina with Macular Complications by Pars Plana Vitrectomy Combined with Episcleral Cryotherapy
Objective. To evaluate the efficacy of pars plana vitrectomy (PPV) combined with episcleral cryotherapy in treating vasoproliferative tumors of the retina (VPTR) with macular complications. Methods. In this retrospective noncomparative interventional case-series analysis, we included 11 eyes of ten...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2021/6667755 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832547052790218752 |
|---|---|
| author | Wenhua Zhang Zeyuan Qiang Hao Song Xiaoli Li Handong Dan Keke Ge Pan Li Zixu Huang Dongdong Wang Feng Chen Bin Zheng Zongming Song |
| author_facet | Wenhua Zhang Zeyuan Qiang Hao Song Xiaoli Li Handong Dan Keke Ge Pan Li Zixu Huang Dongdong Wang Feng Chen Bin Zheng Zongming Song |
| author_sort | Wenhua Zhang |
| collection | DOAJ |
| description | Objective. To evaluate the efficacy of pars plana vitrectomy (PPV) combined with episcleral cryotherapy in treating vasoproliferative tumors of the retina (VPTR) with macular complications. Methods. In this retrospective noncomparative interventional case-series analysis, we included 11 eyes of ten patients diagnosed with VPTR. All patients underwent comprehensive ophthalmic examinations and were treated with PPV combined with episcleral cryotherapy. Best-corrected visual acuity (BCVA), tumor activity, retinal morphological structure, and postoperative complications were evaluated. Results. Macular complications included epimacular membrane (n = 10), macular hole (n = 3), and macular edema (n = 1). Tumors were treated with triple freeze-thaw episcleral cryotherapy during PPV. The mean logarithm of minimal angle of resolution (logMAR) BCVA dropped from 0.62 ± 0.58 to 0.39 ± 0.46. The difference between the mean values of logMAR BCVA before and after treatment was statistically significant (t = 2.48, P=0.033). The tumor activity was controlled effectively in nine cases. Compared with preoperative tumor activity, tumor activity after treatment was significantly lower (P<0.01). The increase of central retinal thickness and the disruption of retinal layers were associated with macular holes, macular edema, and retinal proliferative membrane. After the treatment, visual acuity improved in 91% of the cases, and 73% had no long-term complications. Conclusion. PPV combined with episcleral cryotherapy promoted tumor regression, preserved retinal integrity, and improved visual acuity. Thus, the combination of PPV with episcleral cryotherapy can be considered effective and safe for the management of VPTR with macular complications. |
| format | Article |
| id | doaj-art-f2c1439c127b437b9f9f2b48775c7585 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-f2c1439c127b437b9f9f2b48775c75852025-02-03T06:46:15ZengWileyJournal of Ophthalmology2090-004X2090-00582021-01-01202110.1155/2021/66677556667755Management of Vasoproliferative Tumors of the Retina with Macular Complications by Pars Plana Vitrectomy Combined with Episcleral CryotherapyWenhua Zhang0Zeyuan Qiang1Hao Song2Xiaoli Li3Handong Dan4Keke Ge5Pan Li6Zixu Huang7Dongdong Wang8Feng Chen9Bin Zheng10Zongming Song11Henan University People’s Hospital, Henan Provincial People’s Hospital, Henan Eye Hospital, Zhengzhou 450003, Henan, ChinaHenan University People’s Hospital, Henan Provincial People’s Hospital, Henan Eye Hospital, Zhengzhou 450003, Henan, ChinaZhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Henan Eye Hospital, Zhengzhou 450003, Henan, ChinaHenan Eye Institute, Henan Eye Hospital, Henan Provincial People’s Hospital and Henan University People’s Hospital, Zhengzhou 450003, Henan, ChinaHenan Eye Institute, Henan Eye Hospital, Henan Provincial People’s Hospital and Henan University People’s Hospital, Zhengzhou 450003, Henan, ChinaZhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Henan Eye Hospital, Zhengzhou 450003, Henan, ChinaZhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Henan Eye Hospital, Zhengzhou 450003, Henan, ChinaHenan Eye Institute, Henan Eye Hospital, Henan Provincial People’s Hospital and Henan University People’s Hospital, Zhengzhou 450003, Henan, ChinaHenan Eye Institute, Henan Eye Hospital, Henan Provincial People’s Hospital and Henan University People’s Hospital, Zhengzhou 450003, Henan, ChinaEye Hospital, Wenzhou Medical University, Wenzhou 325000, Zhejiang, ChinaEye Hospital, Wenzhou Medical University, Wenzhou 325000, Zhejiang, ChinaHenan Eye Institute, Henan Eye Hospital, Henan Provincial People’s Hospital and Henan University People’s Hospital, Zhengzhou 450003, Henan, ChinaObjective. To evaluate the efficacy of pars plana vitrectomy (PPV) combined with episcleral cryotherapy in treating vasoproliferative tumors of the retina (VPTR) with macular complications. Methods. In this retrospective noncomparative interventional case-series analysis, we included 11 eyes of ten patients diagnosed with VPTR. All patients underwent comprehensive ophthalmic examinations and were treated with PPV combined with episcleral cryotherapy. Best-corrected visual acuity (BCVA), tumor activity, retinal morphological structure, and postoperative complications were evaluated. Results. Macular complications included epimacular membrane (n = 10), macular hole (n = 3), and macular edema (n = 1). Tumors were treated with triple freeze-thaw episcleral cryotherapy during PPV. The mean logarithm of minimal angle of resolution (logMAR) BCVA dropped from 0.62 ± 0.58 to 0.39 ± 0.46. The difference between the mean values of logMAR BCVA before and after treatment was statistically significant (t = 2.48, P=0.033). The tumor activity was controlled effectively in nine cases. Compared with preoperative tumor activity, tumor activity after treatment was significantly lower (P<0.01). The increase of central retinal thickness and the disruption of retinal layers were associated with macular holes, macular edema, and retinal proliferative membrane. After the treatment, visual acuity improved in 91% of the cases, and 73% had no long-term complications. Conclusion. PPV combined with episcleral cryotherapy promoted tumor regression, preserved retinal integrity, and improved visual acuity. Thus, the combination of PPV with episcleral cryotherapy can be considered effective and safe for the management of VPTR with macular complications.http://dx.doi.org/10.1155/2021/6667755 |
| spellingShingle | Wenhua Zhang Zeyuan Qiang Hao Song Xiaoli Li Handong Dan Keke Ge Pan Li Zixu Huang Dongdong Wang Feng Chen Bin Zheng Zongming Song Management of Vasoproliferative Tumors of the Retina with Macular Complications by Pars Plana Vitrectomy Combined with Episcleral Cryotherapy Journal of Ophthalmology |
| title | Management of Vasoproliferative Tumors of the Retina with Macular Complications by Pars Plana Vitrectomy Combined with Episcleral Cryotherapy |
| title_full | Management of Vasoproliferative Tumors of the Retina with Macular Complications by Pars Plana Vitrectomy Combined with Episcleral Cryotherapy |
| title_fullStr | Management of Vasoproliferative Tumors of the Retina with Macular Complications by Pars Plana Vitrectomy Combined with Episcleral Cryotherapy |
| title_full_unstemmed | Management of Vasoproliferative Tumors of the Retina with Macular Complications by Pars Plana Vitrectomy Combined with Episcleral Cryotherapy |
| title_short | Management of Vasoproliferative Tumors of the Retina with Macular Complications by Pars Plana Vitrectomy Combined with Episcleral Cryotherapy |
| title_sort | management of vasoproliferative tumors of the retina with macular complications by pars plana vitrectomy combined with episcleral cryotherapy |
| url | http://dx.doi.org/10.1155/2021/6667755 |
| work_keys_str_mv | AT wenhuazhang managementofvasoproliferativetumorsoftheretinawithmacularcomplicationsbyparsplanavitrectomycombinedwithepiscleralcryotherapy AT zeyuanqiang managementofvasoproliferativetumorsoftheretinawithmacularcomplicationsbyparsplanavitrectomycombinedwithepiscleralcryotherapy AT haosong managementofvasoproliferativetumorsoftheretinawithmacularcomplicationsbyparsplanavitrectomycombinedwithepiscleralcryotherapy AT xiaolili managementofvasoproliferativetumorsoftheretinawithmacularcomplicationsbyparsplanavitrectomycombinedwithepiscleralcryotherapy AT handongdan managementofvasoproliferativetumorsoftheretinawithmacularcomplicationsbyparsplanavitrectomycombinedwithepiscleralcryotherapy AT kekege managementofvasoproliferativetumorsoftheretinawithmacularcomplicationsbyparsplanavitrectomycombinedwithepiscleralcryotherapy AT panli managementofvasoproliferativetumorsoftheretinawithmacularcomplicationsbyparsplanavitrectomycombinedwithepiscleralcryotherapy AT zixuhuang managementofvasoproliferativetumorsoftheretinawithmacularcomplicationsbyparsplanavitrectomycombinedwithepiscleralcryotherapy AT dongdongwang managementofvasoproliferativetumorsoftheretinawithmacularcomplicationsbyparsplanavitrectomycombinedwithepiscleralcryotherapy AT fengchen managementofvasoproliferativetumorsoftheretinawithmacularcomplicationsbyparsplanavitrectomycombinedwithepiscleralcryotherapy AT binzheng managementofvasoproliferativetumorsoftheretinawithmacularcomplicationsbyparsplanavitrectomycombinedwithepiscleralcryotherapy AT zongmingsong managementofvasoproliferativetumorsoftheretinawithmacularcomplicationsbyparsplanavitrectomycombinedwithepiscleralcryotherapy |