Faecal metaproteomics analysis reveals a high cardiovascular risk profile across healthy individuals and heart failure patients
The gut microbiota is a crucial link between diet and cardiovascular disease (CVD). Using fecal metaproteomics, a method that concurrently captures human gut and microbiome proteins, we determined the crosstalk between gut microbiome, diet, gut health, and CVD. Traditional CVD risk factors (age, BMI...
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| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2024.2441356 |
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| author | Chaoran Yang Leticia Camargo Tavares Han-Chung Lee Joel R. Steele Rosilene V. Ribeiro Anna L. Beale Stephanie Yiallourou Melinda J. Carrington David M. Kaye Geoffrey A. Head Ralf B. Schittenhelm Francine Z. Marques |
| author_facet | Chaoran Yang Leticia Camargo Tavares Han-Chung Lee Joel R. Steele Rosilene V. Ribeiro Anna L. Beale Stephanie Yiallourou Melinda J. Carrington David M. Kaye Geoffrey A. Head Ralf B. Schittenhelm Francine Z. Marques |
| author_sort | Chaoran Yang |
| collection | DOAJ |
| description | The gut microbiota is a crucial link between diet and cardiovascular disease (CVD). Using fecal metaproteomics, a method that concurrently captures human gut and microbiome proteins, we determined the crosstalk between gut microbiome, diet, gut health, and CVD. Traditional CVD risk factors (age, BMI, sex, blood pressure) explained < 10% of the proteome variance. However, unsupervised human protein-based clustering analysis revealed two distinct CVD risk clusters (low-risk and high-risk) with different blood pressure (by 9 mmHg) and sex-dependent dietary potassium and fiber intake. In the human proteome, the low-risk group had lower angiotensin-converting enzymes, inflammatory proteins associated with neutrophil extracellular trap formation and auto-immune diseases. In the microbial proteome, the low-risk group had higher expression of phosphate acetyltransferase that produces SCFAs, particularly in fiber-fermenting bacteria. This model identified severity across phenotypes in heart failure patients and long-term risk of cardiovascular events in a large population-based cohort. These findings underscore multifactorial gut-to-host mechanisms that may underlie risk factors for CVD. |
| format | Article |
| id | doaj-art-f2bfc3c6fc0342cbaa23bcaf14e97809 |
| institution | OA Journals |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-f2bfc3c6fc0342cbaa23bcaf14e978092025-08-20T01:59:47ZengTaylor & Francis GroupGut Microbes1949-09761949-09842025-12-0117110.1080/19490976.2024.2441356Faecal metaproteomics analysis reveals a high cardiovascular risk profile across healthy individuals and heart failure patientsChaoran Yang0Leticia Camargo Tavares1Han-Chung Lee2Joel R. Steele3Rosilene V. Ribeiro4Anna L. Beale5Stephanie Yiallourou6Melinda J. Carrington7David M. Kaye8Geoffrey A. Head9Ralf B. Schittenhelm10Francine Z. Marques11Hypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash, Clayton, AustraliaHypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash, Clayton, AustraliaMonash Proteomics & Metabolomics Platform, Monash Biomedicine Discovery Institute & Department of Biochemistry and Molecular Biology, Monash University, Melbourne, AustraliaMonash Proteomics & Metabolomics Platform, Monash Biomedicine Discovery Institute & Department of Biochemistry and Molecular Biology, Monash University, Melbourne, AustraliaCharles Perkins Centre, University of Sydney, Sydney, AustraliaHeart Failure Research Laboratory, Baker Heart and Diabetes Institute, Melbourne, AustraliaPreclinical Disease and Prevention Unit, Baker Heart and Diabetes Institute, Melbourne, AustraliaPreclinical Disease and Prevention Unit, Baker Heart and Diabetes Institute, Melbourne, AustraliaHeart Failure Research Laboratory, Baker Heart and Diabetes Institute, Melbourne, AustraliaNeuropharmacology Laboratory, Baker Heart and Diabetes Institute, Melbourne, AustraliaMonash Proteomics & Metabolomics Platform, Monash Biomedicine Discovery Institute & Department of Biochemistry and Molecular Biology, Monash University, Melbourne, AustraliaHypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash, Clayton, AustraliaThe gut microbiota is a crucial link between diet and cardiovascular disease (CVD). Using fecal metaproteomics, a method that concurrently captures human gut and microbiome proteins, we determined the crosstalk between gut microbiome, diet, gut health, and CVD. Traditional CVD risk factors (age, BMI, sex, blood pressure) explained < 10% of the proteome variance. However, unsupervised human protein-based clustering analysis revealed two distinct CVD risk clusters (low-risk and high-risk) with different blood pressure (by 9 mmHg) and sex-dependent dietary potassium and fiber intake. In the human proteome, the low-risk group had lower angiotensin-converting enzymes, inflammatory proteins associated with neutrophil extracellular trap formation and auto-immune diseases. In the microbial proteome, the low-risk group had higher expression of phosphate acetyltransferase that produces SCFAs, particularly in fiber-fermenting bacteria. This model identified severity across phenotypes in heart failure patients and long-term risk of cardiovascular events in a large population-based cohort. These findings underscore multifactorial gut-to-host mechanisms that may underlie risk factors for CVD.https://www.tandfonline.com/doi/10.1080/19490976.2024.2441356Metaproteomedisease riskshort-chain fatty acidsmachine learning |
| spellingShingle | Chaoran Yang Leticia Camargo Tavares Han-Chung Lee Joel R. Steele Rosilene V. Ribeiro Anna L. Beale Stephanie Yiallourou Melinda J. Carrington David M. Kaye Geoffrey A. Head Ralf B. Schittenhelm Francine Z. Marques Faecal metaproteomics analysis reveals a high cardiovascular risk profile across healthy individuals and heart failure patients Gut Microbes Metaproteome disease risk short-chain fatty acids machine learning |
| title | Faecal metaproteomics analysis reveals a high cardiovascular risk profile across healthy individuals and heart failure patients |
| title_full | Faecal metaproteomics analysis reveals a high cardiovascular risk profile across healthy individuals and heart failure patients |
| title_fullStr | Faecal metaproteomics analysis reveals a high cardiovascular risk profile across healthy individuals and heart failure patients |
| title_full_unstemmed | Faecal metaproteomics analysis reveals a high cardiovascular risk profile across healthy individuals and heart failure patients |
| title_short | Faecal metaproteomics analysis reveals a high cardiovascular risk profile across healthy individuals and heart failure patients |
| title_sort | faecal metaproteomics analysis reveals a high cardiovascular risk profile across healthy individuals and heart failure patients |
| topic | Metaproteome disease risk short-chain fatty acids machine learning |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2024.2441356 |
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