The Emerging Perspective of Morphine Tolerance: MicroRNAs
Morphine has unfavorable side effects including analgesic tolerance. Morphine tolerance counteracts analgesic efficacy and drives dose escalation. The mechanisms underlying morphine tolerance remain disputed, which has prevented the development of therapies to maximize and sustain analgesic efficacy...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2019/9432965 |
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| _version_ | 1832564927833833472 |
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| author | Teng J. Zhang Yong Qiu Zhen Hua |
| author_facet | Teng J. Zhang Yong Qiu Zhen Hua |
| author_sort | Teng J. Zhang |
| collection | DOAJ |
| description | Morphine has unfavorable side effects including analgesic tolerance. Morphine tolerance counteracts analgesic efficacy and drives dose escalation. The mechanisms underlying morphine tolerance remain disputed, which has prevented the development of therapies to maximize and sustain analgesic efficacy. Morphine tolerance is an adaptive process induced by chronic morphine that has been shown to result from complex alterations at the molecular level with μ opioid receptors (MORs), as well as at the synaptic, cellular, and circuit levels. MicroRNAs are noncoding RNAs that have been proposed to regulate gene expression and degradation at the posttranscriptional level, including the MOR, as well as synaptic plasticity and neuroplasticity, in both the peripheral and central nervous systems. This review covers some of the most striking microRNA functions involved in morphine tolerance and presents limitations on our knowledge of their physiological roles. |
| format | Article |
| id | doaj-art-f2bde55923c7418caf5a7838791ce265 |
| institution | Kabale University |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-f2bde55923c7418caf5a7838791ce2652025-02-03T01:09:54ZengWileyPain Research and Management1203-67651918-15232019-01-01201910.1155/2019/94329659432965The Emerging Perspective of Morphine Tolerance: MicroRNAsTeng J. Zhang0Yong Qiu1Zhen Hua2Department of Anesthesiology, Beijing Hospital, National Center of Gerontology, Beijing 100730, ChinaDepartment of Anesthesiology, Beijing Hospital, National Center of Gerontology, Beijing 100730, ChinaDepartment of Anesthesiology, Beijing Hospital, National Center of Gerontology, Beijing 100730, ChinaMorphine has unfavorable side effects including analgesic tolerance. Morphine tolerance counteracts analgesic efficacy and drives dose escalation. The mechanisms underlying morphine tolerance remain disputed, which has prevented the development of therapies to maximize and sustain analgesic efficacy. Morphine tolerance is an adaptive process induced by chronic morphine that has been shown to result from complex alterations at the molecular level with μ opioid receptors (MORs), as well as at the synaptic, cellular, and circuit levels. MicroRNAs are noncoding RNAs that have been proposed to regulate gene expression and degradation at the posttranscriptional level, including the MOR, as well as synaptic plasticity and neuroplasticity, in both the peripheral and central nervous systems. This review covers some of the most striking microRNA functions involved in morphine tolerance and presents limitations on our knowledge of their physiological roles.http://dx.doi.org/10.1155/2019/9432965 |
| spellingShingle | Teng J. Zhang Yong Qiu Zhen Hua The Emerging Perspective of Morphine Tolerance: MicroRNAs Pain Research and Management |
| title | The Emerging Perspective of Morphine Tolerance: MicroRNAs |
| title_full | The Emerging Perspective of Morphine Tolerance: MicroRNAs |
| title_fullStr | The Emerging Perspective of Morphine Tolerance: MicroRNAs |
| title_full_unstemmed | The Emerging Perspective of Morphine Tolerance: MicroRNAs |
| title_short | The Emerging Perspective of Morphine Tolerance: MicroRNAs |
| title_sort | emerging perspective of morphine tolerance micrornas |
| url | http://dx.doi.org/10.1155/2019/9432965 |
| work_keys_str_mv | AT tengjzhang theemergingperspectiveofmorphinetolerancemicrornas AT yongqiu theemergingperspectiveofmorphinetolerancemicrornas AT zhenhua theemergingperspectiveofmorphinetolerancemicrornas AT tengjzhang emergingperspectiveofmorphinetolerancemicrornas AT yongqiu emergingperspectiveofmorphinetolerancemicrornas AT zhenhua emergingperspectiveofmorphinetolerancemicrornas |