The TRIM22-CDT2 axis is the key mediator of the p53-Rb signals in growth control of HPV-positive cervical carcinoma cells

The TRIM22-CDT2 axis is the key mediator of the p53-Rb signals in growth control of HPV-positive cervical carcinoma cells

Persistent infection with high-risk human papillomavirus (HPV) is the primary contributor to the development of cervical cancer. Although HPV oncoproteins E6 and E7 clearly trigger cervical tumorigenesis by inactivating p53 and Rb pathways, the downstream mediators of p53/Rb inactivation remain elus...

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Bibliographic Details
Main Authors: Qing Zhou, Hongfei Yu, Anliang Dong, Jiani Yi, Jia Li, Xufan Li, Liyuan Zhou, Qiongzi Qiu, Bingjian Lu, Honghe Zhang, Weiguo Lu, Yi Sun, Pengyuan Liu, Yan Lu
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Cervical cancer
CDT2
HPV
senescence
TRIM22
SET8
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000892
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