Affective-cognitive circuits in postoperative appetite reduction: an adaptive neuroimmune response to surgical stress
Postoperative reduction in appetite perception, conceptualized as an interplay between emotion, perception, and cognition, may lead to adverse nutritional outcomes. However, an increasing body of research suggests that it may serve as an adaptive mechanism to inhibit inflammatory responses and regul...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2025.1654559/full |
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| author | Yanbo Sun Yanbo Sun Yanbo Sun Xianrong Bao Yunyun Cen Huiyin Wu Feng Sun Lin Fu Lin Fu |
| author_facet | Yanbo Sun Yanbo Sun Yanbo Sun Xianrong Bao Yunyun Cen Huiyin Wu Feng Sun Lin Fu Lin Fu |
| author_sort | Yanbo Sun |
| collection | DOAJ |
| description | Postoperative reduction in appetite perception, conceptualized as an interplay between emotion, perception, and cognition, may lead to adverse nutritional outcomes. However, an increasing body of research suggests that it may serve as an adaptive mechanism to inhibit inflammatory responses and regulate metabolic burden. This review comprehensively summarizes the multifaceted mechanisms underlying postoperative changes in appetite perception, particularly from the perspectives of immune regulation, inflammatory suppression, and metabolic reprogramming. Special attention is paid to the affective and cognitive dimensions of appetite perception, exploring how emotion-related processing and neurocognitive feedback contribute to appetite perception suppression during recovery. Moreover, this review highlights the clinical significance of these affective-perceptual changes in postoperative nutritional management, emphasizing the need to integrate psychological, perceptual, and neuroimmune factors into patient care strategies. Ultimately, the article explores the potential role of postoperative appetite perception reduction in modulating insulin sensitivity and improving systemic metabolic health. Based on current literature, we advocate for reevaluating appetite perception dynamics during recovery to provide novel theoretical foundations and practical directions for targeted postoperative nutritional interventions. |
| format | Article |
| id | doaj-art-f2bce680c4e54931a71daad51ccac5c4 |
| institution | DOAJ |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj-art-f2bce680c4e54931a71daad51ccac5c42025-08-20T03:03:46ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-08-011910.3389/fnins.2025.16545591654559Affective-cognitive circuits in postoperative appetite reduction: an adaptive neuroimmune response to surgical stressYanbo Sun0Yanbo Sun1Yanbo Sun2Xianrong Bao3Yunyun Cen4Huiyin Wu5Feng Sun6Lin Fu7Lin Fu8Center for Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases, School of Life Sciences, Yunnan University, Kunming, ChinaDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, ChinaGeneral Surgery Department, Weixin County People's Hospital, Zhaotong, ChinaDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, ChinaCenter for Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases, School of Life Sciences, Yunnan University, Kunming, ChinaDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, ChinaCenter for Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases, School of Life Sciences, Yunnan University, Kunming, ChinaKey Laboratory of Tumor Immunological Prevention and Treatment in Yunnan Province, Yan'an Hospital Affiliated to Kunming Medical University, Kunming, ChinaPostoperative reduction in appetite perception, conceptualized as an interplay between emotion, perception, and cognition, may lead to adverse nutritional outcomes. However, an increasing body of research suggests that it may serve as an adaptive mechanism to inhibit inflammatory responses and regulate metabolic burden. This review comprehensively summarizes the multifaceted mechanisms underlying postoperative changes in appetite perception, particularly from the perspectives of immune regulation, inflammatory suppression, and metabolic reprogramming. Special attention is paid to the affective and cognitive dimensions of appetite perception, exploring how emotion-related processing and neurocognitive feedback contribute to appetite perception suppression during recovery. Moreover, this review highlights the clinical significance of these affective-perceptual changes in postoperative nutritional management, emphasizing the need to integrate psychological, perceptual, and neuroimmune factors into patient care strategies. Ultimately, the article explores the potential role of postoperative appetite perception reduction in modulating insulin sensitivity and improving systemic metabolic health. Based on current literature, we advocate for reevaluating appetite perception dynamics during recovery to provide novel theoretical foundations and practical directions for targeted postoperative nutritional interventions.https://www.frontiersin.org/articles/10.3389/fnins.2025.1654559/fullfeeding behaviorappetite perceptioninflammatory responsespostoperativeneuroimmune factors |
| spellingShingle | Yanbo Sun Yanbo Sun Yanbo Sun Xianrong Bao Yunyun Cen Huiyin Wu Feng Sun Lin Fu Lin Fu Affective-cognitive circuits in postoperative appetite reduction: an adaptive neuroimmune response to surgical stress Frontiers in Neuroscience feeding behavior appetite perception inflammatory responses postoperative neuroimmune factors |
| title | Affective-cognitive circuits in postoperative appetite reduction: an adaptive neuroimmune response to surgical stress |
| title_full | Affective-cognitive circuits in postoperative appetite reduction: an adaptive neuroimmune response to surgical stress |
| title_fullStr | Affective-cognitive circuits in postoperative appetite reduction: an adaptive neuroimmune response to surgical stress |
| title_full_unstemmed | Affective-cognitive circuits in postoperative appetite reduction: an adaptive neuroimmune response to surgical stress |
| title_short | Affective-cognitive circuits in postoperative appetite reduction: an adaptive neuroimmune response to surgical stress |
| title_sort | affective cognitive circuits in postoperative appetite reduction an adaptive neuroimmune response to surgical stress |
| topic | feeding behavior appetite perception inflammatory responses postoperative neuroimmune factors |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1654559/full |
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