Mimicking Myelodysplastic Syndrome: Importance of Differential Diagnosis
Copper deficiency is a rare nutritional deficiency with hematological manifestations that mimic those found in myelodysplastic syndrome, a hematological malignancy incurable without allogeneic hematopoietic stem cell transplantation. Bone marrow biopsy findings and peripheral blood counts are oftent...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2021/9661765 |
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| author | Thomas Luo Joanna Zurko John Astle Nirav N. Shah |
| author_facet | Thomas Luo Joanna Zurko John Astle Nirav N. Shah |
| author_sort | Thomas Luo |
| collection | DOAJ |
| description | Copper deficiency is a rare nutritional deficiency with hematological manifestations that mimic those found in myelodysplastic syndrome, a hematological malignancy incurable without allogeneic hematopoietic stem cell transplantation. Bone marrow biopsy findings and peripheral blood counts are oftentimes insufficient to differentiate the two conditions. Moreover, the symptoms of copper deficiency can arise years after the surgery, making diagnosis a challenge. In patients with new-onset pancytopenia, copper deficiency must be considered on the differential, especially in the setting of known risk factors such as bariatric surgery, zinc supplementation, and celiac disease. Herein, we present a case of a 61-year-old female with a remote history of gastric bypass being evaluated for MDS in the context of progressive pancytopenia and new-onset paresthesias. The patient was found to have low serum copper and ceruloplasmin. Copper supplementation largely resolved the hematological abnormalities, but the limb paresthesias remain. This case highlights the need to identify copper deficiency early and distinguish it from MDS in order to prevent permanent neurological deficits and catastrophic response should the patient undergo hematopoietic stem cell transplantation. |
| format | Article |
| id | doaj-art-f2bce36f1ebe4cca8f2bc4f200340c78 |
| institution | Kabale University |
| issn | 2090-6579 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-f2bce36f1ebe4cca8f2bc4f200340c782025-02-03T05:45:37ZengWileyCase Reports in Hematology2090-65792021-01-01202110.1155/2021/9661765Mimicking Myelodysplastic Syndrome: Importance of Differential DiagnosisThomas Luo0Joanna Zurko1John Astle2Nirav N. Shah3BMT & Cellular Therapy ProgramBMT & Cellular Therapy ProgramDepartment of PathologyBMT & Cellular Therapy ProgramCopper deficiency is a rare nutritional deficiency with hematological manifestations that mimic those found in myelodysplastic syndrome, a hematological malignancy incurable without allogeneic hematopoietic stem cell transplantation. Bone marrow biopsy findings and peripheral blood counts are oftentimes insufficient to differentiate the two conditions. Moreover, the symptoms of copper deficiency can arise years after the surgery, making diagnosis a challenge. In patients with new-onset pancytopenia, copper deficiency must be considered on the differential, especially in the setting of known risk factors such as bariatric surgery, zinc supplementation, and celiac disease. Herein, we present a case of a 61-year-old female with a remote history of gastric bypass being evaluated for MDS in the context of progressive pancytopenia and new-onset paresthesias. The patient was found to have low serum copper and ceruloplasmin. Copper supplementation largely resolved the hematological abnormalities, but the limb paresthesias remain. This case highlights the need to identify copper deficiency early and distinguish it from MDS in order to prevent permanent neurological deficits and catastrophic response should the patient undergo hematopoietic stem cell transplantation.http://dx.doi.org/10.1155/2021/9661765 |
| spellingShingle | Thomas Luo Joanna Zurko John Astle Nirav N. Shah Mimicking Myelodysplastic Syndrome: Importance of Differential Diagnosis Case Reports in Hematology |
| title | Mimicking Myelodysplastic Syndrome: Importance of Differential Diagnosis |
| title_full | Mimicking Myelodysplastic Syndrome: Importance of Differential Diagnosis |
| title_fullStr | Mimicking Myelodysplastic Syndrome: Importance of Differential Diagnosis |
| title_full_unstemmed | Mimicking Myelodysplastic Syndrome: Importance of Differential Diagnosis |
| title_short | Mimicking Myelodysplastic Syndrome: Importance of Differential Diagnosis |
| title_sort | mimicking myelodysplastic syndrome importance of differential diagnosis |
| url | http://dx.doi.org/10.1155/2021/9661765 |
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