Comparison of methods to account for relatedness in genome-wide association studies with family-based data.

Comparison of methods to account for relatedness in genome-wide association studies with family-based data.

Approaches based on linear mixed models (LMMs) have recently gained popularity for modelling population substructure and relatedness in genome-wide association studies. In the last few years, a bewildering variety of different LMM methods/software packages have been developed, but it is not always c...

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Bibliographic Details
Main Authors: Jakris Eu-Ahsunthornwattana, E Nancy Miller, Michaela Fakiola, Wellcome Trust Case Control Consortium 2, Selma M B Jeronimo, Jenefer M Blackwell, Heather J Cordell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-07-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1004445
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