Design principles of nuclear receptor signaling: how complex networking improves signal transduction

Design principles of nuclear receptor signaling: how complex networking improves signal transduction

Abstract The topology of nuclear receptor (NR) signaling is captured in a systems biological graphical notation. This enables us to identify a number of ‘design’ aspects of the topology of these networks that might appear unnecessarily complex or even functionally paradoxical. In realistic kinetic m...

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Bibliographic Details
Main Authors: Alexey N Kolodkin, Frank J Bruggeman, Nick Plant, Martijn J Moné, Barbara M Bakker, Moray J Campbell, Johannes P T M van Leeuwen, Carsten Carlberg, Jacky L Snoep, Hans V Westerhoff
Format: Article
Language:English
Published: Springer Nature 2010-12-01
Series:Molecular Systems Biology
Subjects:
biochemical network
kinetic model
nuclear receptor
signaling
systems biology
Online Access:https://doi.org/10.1038/msb.2010.102
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https://doi.org/10.1038/msb.2010.102

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